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• W4295211023 endingPage "2812" @default.
• W4295211023 startingPage "2812" @default.
• W4295211023 abstract "Cyclic GMP-AMP synthase (cGAS) is a predominant and ubiquitously expressed cytosolic onfirmedDNA sensor that activates innate immune responses by producing a second messenger, cyclic GMP-AMP (cGAMP), and the stimulator of interferon genes (STING). cGAS contains a highly disordered N-terminus, which can sense genomic/chromatin DNA, while the C terminal of cGAS binds dsDNA liberated from various sources, including mitochondria, pathogens, and dead cells. Furthermore, cGAS cellular localization dictates its response to foreign versus self-DNA. Recent evidence has also highlighted the importance of dsDNA-induced post-translational modifications of cGAS in modulating inflammatory responses. This review summarizes and analyzes cGAS activity regulation based on structure, sub-cellular localization, post-translational mechanisms, and Ca2+ signaling. We also discussed the role of cGAS activation in different diseases and clinical outcomes." @default.
• W4295211023 created "2022-09-12" @default.
• W4295211023 creator A5068305708 @default.
• W4295211023 creator A5076380311 @default.
• W4295211023 creator A5087479152 @default.
• W4295211023 date "2022-09-08" @default.
• W4295211023 modified "2023-10-18" @default.
• W4295211023 title "Regulation of cGAS Activity and Downstream Signaling" @default.
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