FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295211033> ?p ?o ?g. }

• W4295211033 endingPage "4384" @default.
• W4295211033 startingPage "4384" @default.
• W4295211033 abstract "Although DNA methylation in the gene promoters usually represses gene expression, the TERT hypermethylated oncological region (THOR) located 5' of the hTERT gene is hypermethylated when hTERT is expressed in diverse cancer types, including urothelial cancer (UC).Comprehensive MeDIP and DNA methylation array analyses complemented by the technically independent method of bisulfite genomic sequencing were applied on pathologically reviewed and classified urothelial carcinoma specimens and healthy urothelial tissue samples to reveal the methylation status of THOR in detail.The detailed DNA methylation profiles reveal the exact positions of differentially methylated CpG dinucleotides within THOR in urothelial cancer and provide evidence ofa diverging role of methylation of these CpGs in the regulation of hTERT. In particular, our data suggest a regulating mechanism in which THOR methylation acts on hTERT expression through epigenetic silencing of the lncRNA hTERT antisense promoter-associated (hTAPAS), which represses hTERT.These findings precisely define the most differentially methylated CpGs of THOR in early urothelial cancer, enabling optimal design of Methylation-Specific PCR (MSPCR) primers to reliably probe these methylation differences for diagnostic and prognostic purposes. In addition, this strategy presents a prime example that is also applicable to many other malignancies. Finally, the first evidence for the underlying epigenetic mechanism regulating hTERT expression through the methylation status of THOR is provided." @default.
• W4295211033 created "2022-09-12" @default.
• W4295211033 creator A5000798839 @default.
• W4295211033 creator A5011584203 @default.
• W4295211033 creator A5013762954 @default.
• W4295211033 creator A5017467466 @default.
• W4295211033 creator A5024945919 @default.
• W4295211033 creator A5047804069 @default.
• W4295211033 creator A5048193070 @default.
• W4295211033 date "2022-09-08" @default.
• W4295211033 modified "2023-10-05" @default.
• W4295211033 title "Differential DNA Methylation of THOR and hTAPAS in the Regulation of hTERT and the Diagnosis of Cancer" @default.
• W4295211033 cites W1497143641 @default.
• W4295211033 cites W1543500873 @default.
• W4295211033 cites W1574296676 @default.
• W4295211033 cites W162187343 @default.
• W4295211033 cites W1892268352 @default.
• W4295211033 cites W1908195810 @default.
• W4295211033 cites W2000971601 @default.
• W4295211033 cites W2001828972 @default.
• W4295211033 cites W2004561527 @default.
• W4295211033 cites W2020717634 @default.
• W4295211033 cites W2021489383 @default.
• W4295211033 cites W2030976397 @default.
• W4295211033 cites W2044296969 @default.
• W4295211033 cites W2046466087 @default.
• W4295211033 cites W2047330128 @default.
• W4295211033 cites W2055902044 @default.
• W4295211033 cites W2060755905 @default.
• W4295211033 cites W2092476887 @default.
• W4295211033 cites W2093254408 @default.
• W4295211033 cites W2095696971 @default.
• W4295211033 cites W2102313667 @default.
• W4295211033 cites W2103251300 @default.
• W4295211033 cites W2104500293 @default.
• W4295211033 cites W2105517056 @default.
• W4295211033 cites W2110419228 @default.
• W4295211033 cites W2110727184 @default.
• W4295211033 cites W2111387441 @default.
• W4295211033 cites W2122740168 @default.
• W4295211033 cites W2125453837 @default.
• W4295211033 cites W2129031151 @default.
• W4295211033 cites W2131117209 @default.
• W4295211033 cites W2133038385 @default.
• W4295211033 cites W2321647501 @default.
• W4295211033 cites W2347113937 @default.
• W4295211033 cites W2461972992 @default.
• W4295211033 cites W2466351482 @default.
• W4295211033 cites W2534118209 @default.
• W4295211033 cites W2537230267 @default.
• W4295211033 cites W2748186886 @default.
• W4295211033 cites W2762102492 @default.
• W4295211033 cites W2781377953 @default.
• W4295211033 cites W2790358111 @default.
• W4295211033 cites W2896689522 @default.
• W4295211033 cites W2898125316 @default.
• W4295211033 cites W2915122960 @default.
• W4295211033 cites W3009314719 @default.
• W4295211033 cites W3011600275 @default.
• W4295211033 cites W4251736485 @default.
• W4295211033 doi "https://doi.org/10.3390/cancers14184384" @default.
• W4295211033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36139544" @default.
• W4295211033 hasPublicationYear "2022" @default.
• W4295211033 type Work @default.
• W4295211033 citedByCount "1" @default.
• W4295211033 countsByYear W42952110332023 @default.
• W4295211033 crossrefType "journal-article" @default.
• W4295211033 hasAuthorship W4295211033A5000798839 @default.
• W4295211033 hasAuthorship W4295211033A5011584203 @default.
• W4295211033 hasAuthorship W4295211033A5013762954 @default.
• W4295211033 hasAuthorship W4295211033A5017467466 @default.
• W4295211033 hasAuthorship W4295211033A5024945919 @default.
• W4295211033 hasAuthorship W4295211033A5047804069 @default.
• W4295211033 hasAuthorship W4295211033A5048193070 @default.
• W4295211033 hasBestOaLocation W42952110331 @default.
• W4295211033 hasConcept C101762097 @default.
• W4295211033 hasConcept C104317684 @default.
• W4295211033 hasConcept C116114238 @default.
• W4295211033 hasConcept C121608353 @default.
• W4295211033 hasConcept C125593758 @default.
• W4295211033 hasConcept C140173407 @default.
• W4295211033 hasConcept C150194340 @default.
• W4295211033 hasConcept C189235521 @default.
• W4295211033 hasConcept C190727270 @default.
• W4295211033 hasConcept C33288867 @default.
• W4295211033 hasConcept C41091548 @default.
• W4295211033 hasConcept C502942594 @default.
• W4295211033 hasConcept C54355233 @default.
• W4295211033 hasConcept C86803240 @default.
• W4295211033 hasConcept C94581717 @default.
• W4295211033 hasConceptScore W4295211033C101762097 @default.
• W4295211033 hasConceptScore W4295211033C104317684 @default.
• W4295211033 hasConceptScore W4295211033C116114238 @default.
• W4295211033 hasConceptScore W4295211033C121608353 @default.
• W4295211033 hasConceptScore W4295211033C125593758 @default.
• W4295211033 hasConceptScore W4295211033C140173407 @default.
• W4295211033 hasConceptScore W4295211033C150194340 @default.
• W4295211033 hasConceptScore W4295211033C189235521 @default.

• next