Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295211058> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W4295211058 endingPage "2187" @default.
- W4295211058 startingPage "2187" @default.
- W4295211058 abstract "There is a strong need for biomarkers of rheumatoid arthritis (RA) in all phases of the patient’s journey and to enable the implementation of precision medicine strategies to improve patient care. The objective of this study was to evaluate the presence of anti-protein-arginine deiminase (PAD) 4 IgG and IgA in the sera of RA patients and disease controls, and to investigate their association with joint erosion and biological treatment use. Sera from 104 RA and 155 controls were tested for the presence of anti-PAD4 IgG and IgA using a new particle-based multi-analyte technology (PMAT). Information on the erosive disease and biological treatment use was available for 54 of the RA patients, who were also tested for anti-citrullinated protein antibodies (ACPA). An association between the autoantibodies and these clinical features was investigated. Anti-PAD4 showed sensitivity and specificity values of 25.0% and 94.2% for IgG and of 21.2% and 94.8% for IgA for RA, respectively. The levels of these antibodies were also significantly higher in RA patients vs. controls, in erosive RA vs. non-erosive disease, and in patients under biologics vs. patients that were not on this treatment regimen. The anti-PAD4 IgG and IgA levels were correlated (rho = 0.60, p < 0.0001), but individuals that were positive for only one of the two isotypes were also observed. Anti-PAD4 IgG and IgA are associated with severe RA, and they represent valuable biomarkers for prognosis prediction and patient stratification." @default.
- W4295211058 created "2022-09-12" @default.
- W4295211058 creator A5000160988 @default.
- W4295211058 creator A5016761924 @default.
- W4295211058 creator A5051334937 @default.
- W4295211058 creator A5058361278 @default.
- W4295211058 creator A5069756922 @default.
- W4295211058 date "2022-09-09" @default.
- W4295211058 modified "2023-09-30" @default.
- W4295211058 title "Anti-Protein-Arginine Deiminase 4 IgG and IgA Delineate Severe Rheumatoid Arthritis" @default.
- W4295211058 cites W2015499663 @default.
- W4295211058 cites W2031026678 @default.
- W4295211058 cites W204003194 @default.
- W4295211058 cites W2082888832 @default.
- W4295211058 cites W2113771212 @default.
- W4295211058 cites W2125930376 @default.
- W4295211058 cites W2136894699 @default.
- W4295211058 cites W2138526118 @default.
- W4295211058 cites W2141342904 @default.
- W4295211058 cites W2145437855 @default.
- W4295211058 cites W2162387133 @default.
- W4295211058 cites W2167131572 @default.
- W4295211058 cites W2586749826 @default.
- W4295211058 cites W2756094226 @default.
- W4295211058 cites W2759236476 @default.
- W4295211058 cites W2768048806 @default.
- W4295211058 cites W2778824043 @default.
- W4295211058 cites W2793547099 @default.
- W4295211058 cites W2886363262 @default.
- W4295211058 cites W2897820616 @default.
- W4295211058 cites W2901827656 @default.
- W4295211058 cites W2903431204 @default.
- W4295211058 cites W2910916767 @default.
- W4295211058 cites W2929968164 @default.
- W4295211058 cites W2970697665 @default.
- W4295211058 cites W2972517766 @default.
- W4295211058 cites W2996057353 @default.
- W4295211058 cites W2998546112 @default.
- W4295211058 cites W2999425204 @default.
- W4295211058 cites W3019144294 @default.
- W4295211058 cites W3169056896 @default.
- W4295211058 cites W3196896930 @default.
- W4295211058 cites W4211054359 @default.
- W4295211058 cites W4282931474 @default.
- W4295211058 doi "https://doi.org/10.3390/diagnostics12092187" @default.
- W4295211058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36140588" @default.
- W4295211058 hasPublicationYear "2022" @default.
- W4295211058 type Work @default.
- W4295211058 citedByCount "0" @default.
- W4295211058 crossrefType "journal-article" @default.
- W4295211058 hasAuthorship W4295211058A5000160988 @default.
- W4295211058 hasAuthorship W4295211058A5016761924 @default.
- W4295211058 hasAuthorship W4295211058A5051334937 @default.
- W4295211058 hasAuthorship W4295211058A5058361278 @default.
- W4295211058 hasAuthorship W4295211058A5069756922 @default.
- W4295211058 hasBestOaLocation W42952110581 @default.
- W4295211058 hasConcept C126322002 @default.
- W4295211058 hasConcept C159654299 @default.
- W4295211058 hasConcept C163764329 @default.
- W4295211058 hasConcept C203014093 @default.
- W4295211058 hasConcept C2777575956 @default.
- W4295211058 hasConcept C2779102806 @default.
- W4295211058 hasConcept C2780898057 @default.
- W4295211058 hasConcept C71924100 @default.
- W4295211058 hasConceptScore W4295211058C126322002 @default.
- W4295211058 hasConceptScore W4295211058C159654299 @default.
- W4295211058 hasConceptScore W4295211058C163764329 @default.
- W4295211058 hasConceptScore W4295211058C203014093 @default.
- W4295211058 hasConceptScore W4295211058C2777575956 @default.
- W4295211058 hasConceptScore W4295211058C2779102806 @default.
- W4295211058 hasConceptScore W4295211058C2780898057 @default.
- W4295211058 hasConceptScore W4295211058C71924100 @default.
- W4295211058 hasIssue "9" @default.
- W4295211058 hasLocation W42952110581 @default.
- W4295211058 hasLocation W42952110582 @default.
- W4295211058 hasLocation W42952110583 @default.
- W4295211058 hasLocation W42952110584 @default.
- W4295211058 hasLocation W42952110585 @default.
- W4295211058 hasLocation W42952110586 @default.
- W4295211058 hasOpenAccess W4295211058 @default.
- W4295211058 hasPrimaryLocation W42952110581 @default.
- W4295211058 hasRelatedWork W1995617640 @default.
- W4295211058 hasRelatedWork W2023669480 @default.
- W4295211058 hasRelatedWork W2029980802 @default.
- W4295211058 hasRelatedWork W2031278795 @default.
- W4295211058 hasRelatedWork W2074146762 @default.
- W4295211058 hasRelatedWork W2078060185 @default.
- W4295211058 hasRelatedWork W2078748389 @default.
- W4295211058 hasRelatedWork W2099244599 @default.
- W4295211058 hasRelatedWork W2101875571 @default.
- W4295211058 hasRelatedWork W2425255793 @default.
- W4295211058 hasVolume "12" @default.
- W4295211058 isParatext "false" @default.
- W4295211058 isRetracted "false" @default.
- W4295211058 workType "article" @default.