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• W4295211065 abstract "Large medical centers in urban areas, like Los Angeles, care for a diverse patient population and offer the potential to study the interplay between genetic ancestry and social determinants of health. Here, we explore the implications of genetic ancestry within the University of California, Los Angeles (UCLA) ATLAS Community Health Initiative-an ancestrally diverse biobank of genomic data linked with de-identified electronic health records (EHRs) of UCLA Health patients (N=36,736).We quantify the extensive continental and subcontinental genetic diversity within the ATLAS data through principal component analysis, identity-by-descent, and genetic admixture. We assess the relationship between genetically inferred ancestry (GIA) and >1500 EHR-derived phenotypes (phecodes). Finally, we demonstrate the utility of genetic data linked with EHR to perform ancestry-specific and multi-ancestry genome and phenome-wide scans across a broad set of disease phenotypes.We identify 5 continental-scale GIA clusters including European American (EA), African American (AA), Hispanic Latino American (HL), South Asian American (SAA) and East Asian American (EAA) individuals and 7 subcontinental GIA clusters within the EAA GIA corresponding to Chinese American, Vietnamese American, and Japanese American individuals. Although we broadly find that self-identified race/ethnicity (SIRE) is highly correlated with GIA, we still observe marked differences between the two, emphasizing that the populations defined by these two criteria are not analogous. We find a total of 259 significant associations between continental GIA and phecodes even after accounting for individuals' SIRE, demonstrating that for some phenotypes, GIA provides information not already captured by SIRE. GWAS identifies significant associations for liver disease in the 22q13.31 locus across the HL and EAA GIA groups (HL p-value=2.32×10-16, EAA p-value=6.73×10-11). A subsequent PheWAS at the top SNP reveals significant associations with neurologic and neoplastic phenotypes specifically within the HL GIA group.Overall, our results explore the interplay between SIRE and GIA within a disease context and underscore the utility of studying the genomes of diverse individuals through biobank-scale genotyping linked with EHR-based phenotyping." @default.
• W4295211065 created "2022-09-12" @default.
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• W4295211065 date "2022-09-09" @default.
• W4295211065 modified "2023-10-14" @default.
• W4295211065 title "Leveraging genomic diversity for discovery in an electronic health record linked biobank: the UCLA ATLAS Community Health Initiative" @default.
• W4295211065 cites W1501531968 @default.
• W4295211065 cites W1841846581 @default.
• W4295211065 cites W1854968613 @default.
• W4295211065 cites W1969208427 @default.
• W4295211065 cites W1979677919 @default.
• W4295211065 cites W1984195900 @default.
• W4295211065 cites W2001371486 @default.
• W4295211065 cites W2018564409 @default.
• W4295211065 cites W2020302614 @default.
• W4295211065 cites W2037412424 @default.
• W4295211065 cites W2040600853 @default.
• W4295211065 cites W2058464043 @default.
• W4295211065 cites W2068651465 @default.
• W4295211065 cites W2074048861 @default.
• W4295211065 cites W2087363950 @default.
• W4295211065 cites W2090626196 @default.
• W4295211065 cites W2092449206 @default.
• W4295211065 cites W2098829456 @default.
• W4295211065 cites W2099085143 @default.
• W4295211065 cites W2102213696 @default.
• W4295211065 cites W2102215872 @default.
• W4295211065 cites W2104549677 @default.
• W4295211065 cites W2108009633 @default.
• W4295211065 cites W2109780493 @default.
• W4295211065 cites W2113105800 @default.
• W4295211065 cites W2115193738 @default.
• W4295211065 cites W2119444539 @default.
• W4295211065 cites W2125699230 @default.
• W4295211065 cites W2133148918 @default.
• W4295211065 cites W2144990191 @default.
• W4295211065 cites W2148221344 @default.
• W4295211065 cites W2163104142 @default.
• W4295211065 cites W2164998314 @default.
• W4295211065 cites W2167482691 @default.
• W4295211065 cites W2217442075 @default.
• W4295211065 cites W2318933482 @default.
• W4295211065 cites W2332282497 @default.
• W4295211065 cites W2510973425 @default.
• W4295211065 cites W2522993044 @default.
• W4295211065 cites W2529241974 @default.
• W4295211065 cites W2531587846 @default.
• W4295211065 cites W2586610513 @default.
• W4295211065 cites W2612716641 @default.
• W4295211065 cites W2791466251 @default.
• W4295211065 cites W2792991562 @default.
• W4295211065 cites W2796061656 @default.
• W4295211065 cites W2886283492 @default.
• W4295211065 cites W2889814656 @default.
• W4295211065 cites W2895917461 @default.
• W4295211065 cites W2901776617 @default.
• W4295211065 cites W2904194155 @default.
• W4295211065 cites W2911690514 @default.
• W4295211065 cites W2922534626 @default.
• W4295211065 cites W2923757114 @default.
• W4295211065 cites W2932671560 @default.
• W4295211065 cites W2944759244 @default.
• W4295211065 cites W2949004837 @default.
• W4295211065 cites W2951349772 @default.
• W4295211065 cites W2951939515 @default.
• W4295211065 cites W2952727348 @default.
• W4295211065 cites W2970480306 @default.
• W4295211065 cites W2976146569 @default.
• W4295211065 cites W2981869278 @default.
• W4295211065 cites W2990059271 @default.
• W4295211065 cites W2998774362 @default.
• W4295211065 cites W3007248039 @default.
• W4295211065 cites W3009980214 @default.
• W4295211065 cites W3011413344 @default.
• W4295211065 cites W3014994762 @default.
• W4295211065 cites W3033281579 @default.

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