Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295215075> ?p ?o ?g. }
- W4295215075 endingPage "529" @default.
- W4295215075 startingPage "529" @default.
- W4295215075 abstract "Tetrabromobisphenol A (TBBPA) is a flame retardant widely used to reduce flammability. It is an endocrine disruptor, and due to constant human exposure, some concerns have been raised regarding its impact on human health. Studies showed that TBBPA affects oxidative stress, cell proliferation and intracellular calcium levels. However, the vascular consequences of TBBPA exposure are still relatively unexplored. Hence, this work aimed to analyse TBBPA effects on rat aortic smooth muscle and its action mechanisms. Through an ex vivo approach, Wistar rat aortas were used in an organ bath to evaluate the vascular effect of TBBPA (0.01–100 μM). Additionally, TBBPA’s mode of action was studied through calcium and potassium channel inhibitors. Resorting to in vitro studies, A7r5 cells were used to analyse L-Type voltage-gated calcium channel (VGCC) activity through the whole-cell configuration of the patch clamp technique, and the mRNA expression of proteins and ion channels involved in vascular contractility. The results showed vasorelaxation of rat aorta induced by TBBPA exposure, involving the inactivation of L-Type VGCC and activation of potassium channels, and the modulation of mRNA expression of L-type calcium and large-conductance calcium 1.1 and the BKCa 1.1 α- and β1 -subunit channels, soluble guanylyl cyclase and protein Kinase G." @default.
- W4295215075 created "2022-09-12" @default.
- W4295215075 creator A5013163234 @default.
- W4295215075 creator A5025140163 @default.
- W4295215075 creator A5031944470 @default.
- W4295215075 creator A5060607126 @default.
- W4295215075 creator A5074018044 @default.
- W4295215075 date "2022-09-09" @default.
- W4295215075 modified "2023-10-10" @default.
- W4295215075 title "Vascular Response of Tetrabromobisphenol a in Rat Aorta: Calcium Channels Inhibition and Potassium Channels Activation" @default.
- W4295215075 cites W1570704324 @default.
- W4295215075 cites W1659749843 @default.
- W4295215075 cites W1979084820 @default.
- W4295215075 cites W1982621943 @default.
- W4295215075 cites W1990305972 @default.
- W4295215075 cites W1995583825 @default.
- W4295215075 cites W2011175220 @default.
- W4295215075 cites W2016082680 @default.
- W4295215075 cites W2018241583 @default.
- W4295215075 cites W2025869678 @default.
- W4295215075 cites W2039636568 @default.
- W4295215075 cites W2041680723 @default.
- W4295215075 cites W2045753556 @default.
- W4295215075 cites W2062329660 @default.
- W4295215075 cites W2063319145 @default.
- W4295215075 cites W2074641150 @default.
- W4295215075 cites W2078861858 @default.
- W4295215075 cites W2092937320 @default.
- W4295215075 cites W2094452874 @default.
- W4295215075 cites W2098478805 @default.
- W4295215075 cites W2108244474 @default.
- W4295215075 cites W2118677633 @default.
- W4295215075 cites W2126914997 @default.
- W4295215075 cites W2137407264 @default.
- W4295215075 cites W2150341119 @default.
- W4295215075 cites W2153466256 @default.
- W4295215075 cites W2159317013 @default.
- W4295215075 cites W2163044427 @default.
- W4295215075 cites W2589605945 @default.
- W4295215075 cites W2596094280 @default.
- W4295215075 cites W2597137467 @default.
- W4295215075 cites W2609061311 @default.
- W4295215075 cites W2774673912 @default.
- W4295215075 cites W2790510014 @default.
- W4295215075 cites W2793611376 @default.
- W4295215075 cites W2801685850 @default.
- W4295215075 cites W2802001178 @default.
- W4295215075 cites W2895097849 @default.
- W4295215075 cites W2903701597 @default.
- W4295215075 cites W3009864904 @default.
- W4295215075 cites W3021367274 @default.
- W4295215075 cites W3081134113 @default.
- W4295215075 cites W3104915711 @default.
- W4295215075 cites W3137782172 @default.
- W4295215075 cites W3165492918 @default.
- W4295215075 cites W4200495670 @default.
- W4295215075 cites W4220882939 @default.
- W4295215075 cites W4289528108 @default.
- W4295215075 doi "https://doi.org/10.3390/toxics10090529" @default.
- W4295215075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36136495" @default.
- W4295215075 hasPublicationYear "2022" @default.
- W4295215075 type Work @default.
- W4295215075 citedByCount "2" @default.
- W4295215075 countsByYear W42952150752022 @default.
- W4295215075 countsByYear W42952150752023 @default.
- W4295215075 crossrefType "journal-article" @default.
- W4295215075 hasAuthorship W4295215075A5013163234 @default.
- W4295215075 hasAuthorship W4295215075A5025140163 @default.
- W4295215075 hasAuthorship W4295215075A5031944470 @default.
- W4295215075 hasAuthorship W4295215075A5060607126 @default.
- W4295215075 hasAuthorship W4295215075A5074018044 @default.
- W4295215075 hasBestOaLocation W42952150751 @default.
- W4295215075 hasConcept C117499352 @default.
- W4295215075 hasConcept C126322002 @default.
- W4295215075 hasConcept C134018914 @default.
- W4295215075 hasConcept C149614440 @default.
- W4295215075 hasConcept C149786707 @default.
- W4295215075 hasConcept C170493617 @default.
- W4295215075 hasConcept C178790620 @default.
- W4295215075 hasConcept C181080969 @default.
- W4295215075 hasConcept C185592680 @default.
- W4295215075 hasConcept C18699975 @default.
- W4295215075 hasConcept C205474432 @default.
- W4295215075 hasConcept C2779395532 @default.
- W4295215075 hasConcept C2779411790 @default.
- W4295215075 hasConcept C2780287514 @default.
- W4295215075 hasConcept C2992686903 @default.
- W4295215075 hasConcept C50254741 @default.
- W4295215075 hasConcept C519063684 @default.
- W4295215075 hasConcept C55493867 @default.
- W4295215075 hasConcept C61144316 @default.
- W4295215075 hasConcept C71924100 @default.
- W4295215075 hasConcept C83743174 @default.
- W4295215075 hasConcept C85520022 @default.
- W4295215075 hasConcept C86803240 @default.
- W4295215075 hasConcept C98274493 @default.
- W4295215075 hasConceptScore W4295215075C117499352 @default.
- W4295215075 hasConceptScore W4295215075C126322002 @default.