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- W4295222457 endingPage "3176" @default.
- W4295222457 startingPage "3160" @default.
- W4295222457 abstract "Tumor-initiating cells (TICs) are a rare sub-population of cells within the bulk of a tumor that are major contributors to tumor initiation, metastasis, and chemoresistance. TICs have a stem-cell-like phenotype that is dictated by the expression of master regulator transcription factors, including OCT4, NANOG, and SOX2. These transcription factors are expressed via activation of multiple signaling pathways that drive cancer initiation and progression. Importantly, these same signaling pathways can be activated by select chemokine receptors. Chemokine receptors are increasingly being revealed as major drivers of the TIC phenotype, as their signaling can lead to activation of stemness-controlling transcription factors. Additionally, the cell surface expression of chemokine receptors provides a unique therapeutic target to disrupt signaling pathways that control the expression of master regulator transcription factors and the TIC phenotype. This review summarizes the master regulator transcription factors known to dictate the TIC phenotype, along with the complex signaling pathways that can mediate their expression and the chemokine receptors that are most upstream of this phenotype." @default.
- W4295222457 created "2022-09-12" @default.
- W4295222457 creator A5004534548 @default.
- W4295222457 creator A5020698285 @default.
- W4295222457 creator A5021021049 @default.
- W4295222457 creator A5034449837 @default.
- W4295222457 creator A5058154140 @default.
- W4295222457 date "2022-01-01" @default.
- W4295222457 modified "2023-10-01" @default.
- W4295222457 title "Regulation of Tumor and Metastasis Initiation by Chemokine Receptors" @default.
- W4295222457 cites W1037161726 @default.
- W4295222457 cites W1438161774 @default.
- W4295222457 cites W1488181476 @default.
- W4295222457 cites W1515974526 @default.
- W4295222457 cites W1575102738 @default.
- W4295222457 cites W1600560134 @default.
- W4295222457 cites W1831549537 @default.
- W4295222457 cites W1877598057 @default.
- W4295222457 cites W1904221680 @default.
- W4295222457 cites W1912771734 @default.
- W4295222457 cites W1966565248 @default.
- W4295222457 cites W1972940865 @default.
- W4295222457 cites W1983201135 @default.
- W4295222457 cites W1986711353 @default.
- W4295222457 cites W1987757775 @default.
- W4295222457 cites W1990757263 @default.
- W4295222457 cites W1994928797 @default.
- W4295222457 cites W1998389907 @default.
- W4295222457 cites W1999503941 @default.
- W4295222457 cites W2000098894 @default.
- W4295222457 cites W2000749710 @default.
- W4295222457 cites W2003068820 @default.
- W4295222457 cites W2004624656 @default.
- W4295222457 cites W2010608530 @default.
- W4295222457 cites W2012087132 @default.
- W4295222457 cites W2013975797 @default.
- W4295222457 cites W2017050785 @default.
- W4295222457 cites W2020228504 @default.
- W4295222457 cites W2020262790 @default.
- W4295222457 cites W2023427658 @default.
- W4295222457 cites W2025915231 @default.
- W4295222457 cites W2026755839 @default.
- W4295222457 cites W2030689322 @default.
- W4295222457 cites W2037721698 @default.
- W4295222457 cites W2038884631 @default.
- W4295222457 cites W2039753443 @default.
- W4295222457 cites W2051055358 @default.
- W4295222457 cites W2055200188 @default.
- W4295222457 cites W2060344107 @default.
- W4295222457 cites W2062729664 @default.
- W4295222457 cites W2063401578 @default.
- W4295222457 cites W2066808368 @default.
- W4295222457 cites W2068167874 @default.
- W4295222457 cites W2070212400 @default.
- W4295222457 cites W2073180939 @default.
- W4295222457 cites W2073759231 @default.
- W4295222457 cites W2075006530 @default.
- W4295222457 cites W2081028905 @default.
- W4295222457 cites W2086734345 @default.
- W4295222457 cites W2087129977 @default.
- W4295222457 cites W2087861588 @default.
- W4295222457 cites W2093921289 @default.
- W4295222457 cites W2095782040 @default.
- W4295222457 cites W2101547995 @default.
- W4295222457 cites W2105019450 @default.
- W4295222457 cites W2107461722 @default.
- W4295222457 cites W2108961002 @default.
- W4295222457 cites W2110567472 @default.
- W4295222457 cites W2111840545 @default.
- W4295222457 cites W2116576993 @default.
- W4295222457 cites W2117623697 @default.
- W4295222457 cites W2124343538 @default.
- W4295222457 cites W2126851387 @default.
- W4295222457 cites W2126972955 @default.
- W4295222457 cites W2129148890 @default.
- W4295222457 cites W2129741568 @default.
- W4295222457 cites W2133117291 @default.
- W4295222457 cites W2136875995 @default.
- W4295222457 cites W2138283810 @default.
- W4295222457 cites W2138784667 @default.
- W4295222457 cites W2145738273 @default.
- W4295222457 cites W2146749966 @default.
- W4295222457 cites W2147243234 @default.
- W4295222457 cites W2147303583 @default.
- W4295222457 cites W2152217705 @default.
- W4295222457 cites W2152770189 @default.
- W4295222457 cites W2154210454 @default.
- W4295222457 cites W2160138651 @default.
- W4295222457 cites W2162654432 @default.
- W4295222457 cites W2163527113 @default.
- W4295222457 cites W2165275830 @default.
- W4295222457 cites W2169751494 @default.
- W4295222457 cites W2182257602 @default.
- W4295222457 cites W2209250832 @default.
- W4295222457 cites W2221223920 @default.
- W4295222457 cites W2253785907 @default.
- W4295222457 cites W2264711365 @default.
- W4295222457 cites W2265549878 @default.