FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295232915> ?p ?o ?g. }

• W4295232915 abstract "Anatomic variation or early differences in glucose metabolism have been linked to the development of type 1 diabetes. We aimed to describe early glucose metabolism based on HbA1c, oral glucose tolerance test (OGTT), and random plasma glucose years before the presentation of type 1 diabetes in five risk groups based on autoantibody combinations. For the first time, we were able to include for comparison children with very low risk of progression to type 1 diabetes.The Finnish Diabetes Prediction and Prevention birth cohort study screened newborn infants for HLA susceptibility to type 1 diabetes since 1994. Those carrying a risk genotype were prospectively followed up with islet autoantibody testing. Glucose parameters were obtained starting from the time of seroconversion. By 31 August 2014, 1162 children had developed at least one islet autoantibody and were included in the current study. Type 1 diabetes was diagnosed in 335 children (progressors). In the non-progressor groups, 207 developed multiple (≥2) biochemical islet autoantibodies, 229 a single biochemical autoantibody, 370 ICA only, and 64 transient autoantibodies. Children were divided into five risk groups. Glucose metabolism was evaluated.We observed lower HbA1c values in early follow-up 4.5 to 6.0 years before diagnosis in the progressors when compared to the same time in children with a single biochemical autoantibody or low-risk (ICA only and transient) participants, who did not progress to clinical type 1 diabetes. However, no such differences were observed in OGTTs or random plasma glucose. The variation was minimal in glucose values in the low-risk groups.We report the possibility of early alteration in glucose metabolism in future progressors. This could suggest early defects in multiple glucose-regulating hormones." @default.
• W4295232915 created "2022-09-12" @default.
• W4295232915 creator A5001640598 @default.
• W4295232915 creator A5002338181 @default.
• W4295232915 creator A5013587373 @default.
• W4295232915 creator A5027730640 @default.
• W4295232915 creator A5039736447 @default.
• W4295232915 creator A5066618511 @default.
• W4295232915 creator A5088970962 @default.
• W4295232915 date "2022-09-12" @default.
• W4295232915 modified "2023-09-26" @default.
• W4295232915 title "Early glucose metabolism in children at risk for type 1 diabetes based on islet autoantibodies compared to low-risk control groups" @default.
• W4295232915 cites W1489310347 @default.
• W4295232915 cites W1565235211 @default.
• W4295232915 cites W1894747557 @default.
• W4295232915 cites W1942296996 @default.
• W4295232915 cites W2013605176 @default.
• W4295232915 cites W2031364732 @default.
• W4295232915 cites W2091573025 @default.
• W4295232915 cites W2095256598 @default.
• W4295232915 cites W2101372260 @default.
• W4295232915 cites W2108975920 @default.
• W4295232915 cites W2110785364 @default.
• W4295232915 cites W2113217592 @default.
• W4295232915 cites W2124712956 @default.
• W4295232915 cites W2130601108 @default.
• W4295232915 cites W2132216352 @default.
• W4295232915 cites W2133745351 @default.
• W4295232915 cites W2134293572 @default.
• W4295232915 cites W2151627127 @default.
• W4295232915 cites W2156470388 @default.
• W4295232915 cites W2158880005 @default.
• W4295232915 cites W216335904 @default.
• W4295232915 cites W2164825249 @default.
• W4295232915 cites W2267897056 @default.
• W4295232915 cites W2438883383 @default.
• W4295232915 cites W2480518727 @default.
• W4295232915 cites W2504274461 @default.
• W4295232915 cites W3039233428 @default.
• W4295232915 cites W3171115266 @default.
• W4295232915 cites W4281692879 @default.
• W4295232915 doi "https://doi.org/10.3389/fendo.2022.972714" @default.
• W4295232915 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36171903" @default.
• W4295232915 hasPublicationYear "2022" @default.
• W4295232915 type Work @default.
• W4295232915 citedByCount "0" @default.
• W4295232915 crossrefType "journal-article" @default.
• W4295232915 hasAuthorship W4295232915A5001640598 @default.
• W4295232915 hasAuthorship W4295232915A5002338181 @default.
• W4295232915 hasAuthorship W4295232915A5013587373 @default.
• W4295232915 hasAuthorship W4295232915A5027730640 @default.
• W4295232915 hasAuthorship W4295232915A5039736447 @default.
• W4295232915 hasAuthorship W4295232915A5066618511 @default.
• W4295232915 hasAuthorship W4295232915A5088970962 @default.
• W4295232915 hasBestOaLocation W42952329151 @default.
• W4295232915 hasConcept C126322002 @default.
• W4295232915 hasConcept C134018914 @default.
• W4295232915 hasConcept C159654299 @default.
• W4295232915 hasConcept C163764329 @default.
• W4295232915 hasConcept C165220095 @default.
• W4295232915 hasConcept C203014093 @default.
• W4295232915 hasConcept C2777180221 @default.
• W4295232915 hasConcept C2777451964 @default.
• W4295232915 hasConcept C2779668308 @default.
• W4295232915 hasConcept C2781232474 @default.
• W4295232915 hasConcept C555293320 @default.
• W4295232915 hasConcept C71924100 @default.
• W4295232915 hasConcept C72563966 @default.
• W4295232915 hasConceptScore W4295232915C126322002 @default.
• W4295232915 hasConceptScore W4295232915C134018914 @default.
• W4295232915 hasConceptScore W4295232915C159654299 @default.
• W4295232915 hasConceptScore W4295232915C163764329 @default.
• W4295232915 hasConceptScore W4295232915C165220095 @default.
• W4295232915 hasConceptScore W4295232915C203014093 @default.
• W4295232915 hasConceptScore W4295232915C2777180221 @default.
• W4295232915 hasConceptScore W4295232915C2777451964 @default.
• W4295232915 hasConceptScore W4295232915C2779668308 @default.
• W4295232915 hasConceptScore W4295232915C2781232474 @default.
• W4295232915 hasConceptScore W4295232915C555293320 @default.
• W4295232915 hasConceptScore W4295232915C71924100 @default.
• W4295232915 hasConceptScore W4295232915C72563966 @default.
• W4295232915 hasLocation W42952329151 @default.
• W4295232915 hasLocation W42952329152 @default.
• W4295232915 hasLocation W42952329153 @default.
• W4295232915 hasLocation W42952329154 @default.
• W4295232915 hasLocation W42952329155 @default.
• W4295232915 hasLocation W42952329156 @default.
• W4295232915 hasOpenAccess W4295232915 @default.
• W4295232915 hasPrimaryLocation W42952329151 @default.
• W4295232915 hasRelatedWork W1871504092 @default.
• W4295232915 hasRelatedWork W1914846470 @default.
• W4295232915 hasRelatedWork W2049316221 @default.
• W4295232915 hasRelatedWork W2060255031 @default.
• W4295232915 hasRelatedWork W2063257499 @default.
• W4295232915 hasRelatedWork W2077402733 @default.
• W4295232915 hasRelatedWork W2109629947 @default.
• W4295232915 hasRelatedWork W2144747390 @default.
• W4295232915 hasRelatedWork W2163842070 @default.
• W4295232915 hasRelatedWork W2948244216 @default.
• W4295232915 hasVolume "13" @default.

• next