Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295233191> ?p ?o ?g. }
- W4295233191 abstract "Ulcerative colitis is one of the main gastrointestinal diseases that threaten human health. This study investigated the effect of Limosilactobacillus fermentum HFY06 (LF-HFY06) on dextran sulfate sodium (DSS)-induced murine colitis. The protective effect of LF-HFY06 was evaluated by examining the length and histopathological sections of colon, related biochemical indicators, and genes related to inflammation. Direct and microscopic observations showed that LF-HFY06 increased the length of the colon and ameliorated the pathological damage induced by DSS. The biochemical indicators showed that LF-HFY06 enhanced the activities of antioxidant enzymes total superoxide dismutase (T-SOD) and catalase (CAT) in serum, while reducing the level of malondialdehyde (MDA). It was also observed that the serum inflammatory cytokines levels of tumor necrosis factor-α (TNF-α), interferon (IFN)-γ, interleukin (IL)-1β, IL-6, and IL-12 were decreased, and the anti-inflammatory cytokine IL-10 level was increased. The qPCR experiment revealed that LF-HFY06 downregulated the mRNA expression levels of nuclear factor-κB-p65 ( Rela ), Tnf , Il 1b , Il 6 , and prostaglandin-endoperoxide synthase 2 ( Ptgs2 ) in colon tissues, and upregulated the mRNA expression of NF-κB inhibitor-α ( Nfkbia ) and Il 10 . These data indicated that LF-HFY06 inhibited inflammation through the NF-κB signaling pathway to prevent the occurrence and development of colitis. This research demonstrates that probiotics LF-HFY06 have the potential to prevent and treat colitis." @default.
- W4295233191 created "2022-09-12" @default.
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- W4295233191 date "2022-09-12" @default.
- W4295233191 modified "2023-09-26" @default.
- W4295233191 title "Protective effect of Limosilactobacillus fermentum HFY06 on dextran sulfate sodium-induced colitis in mice" @default.
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- W4295233191 doi "https://doi.org/10.3389/fmicb.2022.935792" @default.
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