FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295234311> ?p ?o ?g. }

• W4295234311 abstract "During organ transplantation, ischemia/reperfusion injury and pre-formed anti-HLA antibodies are the main cause of delayed graft function and recovery through the activation of the complement system. By supplying oxygen during transplantation, M101 is suspected to avoid complement activation, however, a direct effect exerted by M101 on this pathway is unknown. This was tested by using functional assays (lymphocytotoxic crossmatch test, C3d Luminex-based assay, 50% complement hemolysis [CH50], and 50% alternative complement pathway [AP50/AH50]), and quantitative assays (C3, C3a, C4, C5, C5a, C6, C7, C8, C9 and sC5b-9). M101 interferes with the anti-HLA lymphocytotoxic crossmatch assay, and this effect is complement-dependent as M101 inhibits the classical complement pathway (CH50) in a dose-dependent and stable manner. Such inhibition was independent from a proteolytic effect (fractions C3 to C9) but related to a dose-dependent inhibition of the C3 convertase as demonstrated by exploring downstream the release of the anaphylatoxins (C3a and C5a), C3d, and sC5b-9. The C3 convertase inhibition in the presence of M101 was further demonstrated in the AP50/AH50 assay. In conclusion, the use of M101 avoids the activation of the complement pathway, which constitutes an additional advantage for this extracellular hemoglobin to preserve grafts from ischemia/reperfusion injury and preformed anti-HLA antibodies." @default.
• W4295234311 created "2022-09-12" @default.
• W4295234311 creator A5011699827 @default.
• W4295234311 creator A5028053055 @default.
• W4295234311 creator A5040346516 @default.
• W4295234311 creator A5040480966 @default.
• W4295234311 creator A5056809198 @default.
• W4295234311 creator A5069308028 @default.
• W4295234311 creator A5085167332 @default.
• W4295234311 creator A5085513812 @default.
• W4295234311 creator A5090535752 @default.
• W4295234311 date "2022-09-12" @default.
• W4295234311 modified "2023-10-18" @default.
• W4295234311 title "The oxygen carrier M101 alleviates complement activation, which may be beneficial for donor organ preservation" @default.
• W4295234311 cites W1968106241 @default.
• W4295234311 cites W1973896538 @default.
• W4295234311 cites W1981296681 @default.
• W4295234311 cites W2008093279 @default.
• W4295234311 cites W2025234351 @default.
• W4295234311 cites W2040405249 @default.
• W4295234311 cites W2051382343 @default.
• W4295234311 cites W2082747121 @default.
• W4295234311 cites W2116044709 @default.
• W4295234311 cites W2122918206 @default.
• W4295234311 cites W2152757679 @default.
• W4295234311 cites W2155807513 @default.
• W4295234311 cites W2161533700 @default.
• W4295234311 cites W2581275870 @default.
• W4295234311 cites W2617629406 @default.
• W4295234311 cites W2718198128 @default.
• W4295234311 cites W2781442716 @default.
• W4295234311 cites W2789954603 @default.
• W4295234311 cites W2895199523 @default.
• W4295234311 cites W2898534034 @default.
• W4295234311 cites W2942193435 @default.
• W4295234311 cites W2947171827 @default.
• W4295234311 cites W2948402211 @default.
• W4295234311 cites W3004726001 @default.
• W4295234311 cites W3059402112 @default.
• W4295234311 cites W3083779226 @default.
• W4295234311 cites W3087090615 @default.
• W4295234311 cites W3112246037 @default.
• W4295234311 cites W3176893528 @default.
• W4295234311 cites W3191269741 @default.
• W4295234311 cites W3199114514 @default.
• W4295234311 cites W3210040773 @default.
• W4295234311 cites W3213181265 @default.
• W4295234311 cites W4200299859 @default.
• W4295234311 cites W4225568570 @default.
• W4295234311 doi "https://doi.org/10.3389/fimmu.2022.1006761" @default.
• W4295234311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36172347" @default.
• W4295234311 hasPublicationYear "2022" @default.
• W4295234311 type Work @default.
• W4295234311 citedByCount "2" @default.
• W4295234311 countsByYear W42952343112023 @default.
• W4295234311 crossrefType "journal-article" @default.
• W4295234311 hasAuthorship W4295234311A5011699827 @default.
• W4295234311 hasAuthorship W4295234311A5028053055 @default.
• W4295234311 hasAuthorship W4295234311A5040346516 @default.
• W4295234311 hasAuthorship W4295234311A5040480966 @default.
• W4295234311 hasAuthorship W4295234311A5056809198 @default.
• W4295234311 hasAuthorship W4295234311A5069308028 @default.
• W4295234311 hasAuthorship W4295234311A5085167332 @default.
• W4295234311 hasAuthorship W4295234311A5085513812 @default.
• W4295234311 hasAuthorship W4295234311A5090535752 @default.
• W4295234311 hasBestOaLocation W42952343111 @default.
• W4295234311 hasConcept C111684460 @default.
• W4295234311 hasConcept C126322002 @default.
• W4295234311 hasConcept C159654299 @default.
• W4295234311 hasConcept C171279029 @default.
• W4295234311 hasConcept C185592680 @default.
• W4295234311 hasConcept C189446657 @default.
• W4295234311 hasConcept C203014093 @default.
• W4295234311 hasConcept C2779902561 @default.
• W4295234311 hasConcept C2910311954 @default.
• W4295234311 hasConcept C2911091166 @default.
• W4295234311 hasConcept C541997718 @default.
• W4295234311 hasConcept C71318922 @default.
• W4295234311 hasConcept C71924100 @default.
• W4295234311 hasConcept C86803240 @default.
• W4295234311 hasConcept C9478725 @default.
• W4295234311 hasConcept C95444343 @default.
• W4295234311 hasConceptScore W4295234311C111684460 @default.
• W4295234311 hasConceptScore W4295234311C126322002 @default.
• W4295234311 hasConceptScore W4295234311C159654299 @default.
• W4295234311 hasConceptScore W4295234311C171279029 @default.
• W4295234311 hasConceptScore W4295234311C185592680 @default.
• W4295234311 hasConceptScore W4295234311C189446657 @default.
• W4295234311 hasConceptScore W4295234311C203014093 @default.
• W4295234311 hasConceptScore W4295234311C2779902561 @default.
• W4295234311 hasConceptScore W4295234311C2910311954 @default.
• W4295234311 hasConceptScore W4295234311C2911091166 @default.
• W4295234311 hasConceptScore W4295234311C541997718 @default.
• W4295234311 hasConceptScore W4295234311C71318922 @default.
• W4295234311 hasConceptScore W4295234311C71924100 @default.
• W4295234311 hasConceptScore W4295234311C86803240 @default.
• W4295234311 hasConceptScore W4295234311C9478725 @default.
• W4295234311 hasConceptScore W4295234311C95444343 @default.
• W4295234311 hasLocation W42952343111 @default.
• W4295234311 hasLocation W42952343112 @default.

• next