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- W4295241432 endingPage "102482" @default.
- W4295241432 startingPage "102482" @default.
- W4295241432 abstract "The small multidrug resistance (SMR) family is composed of widespread microbial membrane proteins that fulfill different transport functions. Four functional SMR subtypes have been identified, which variously transport the small, charged metabolite guanidinium, bulky hydrophobic drugs and antiseptics, polyamines, and glycolipids across the membrane bilayer. The transporters possess a minimalist architecture, with ∼100-residue subunits that require assembly into homodimers or heterodimers for transport. In part because of their simple construction, the SMRs are a tractable system for biochemical and biophysical analysis. Studies of SMR transporters over the last 25 years have yielded deep insights for diverse fields, including membrane protein topology and evolution, mechanisms of membrane transport, and bacterial multidrug resistance. Here, we review recent advances in understanding the structures and functions of SMR transporters. New molecular structures of SMRs representing two of the four functional subtypes reveal the conserved structural features that have permitted the emergence of disparate substrate transport functions in the SMR family and illuminate structural similarities with a distantly related membrane transporter family, SLC35/DMT." @default.
- W4295241432 created "2022-09-12" @default.
- W4295241432 creator A5018640288 @default.
- W4295241432 creator A5080561155 @default.
- W4295241432 creator A5080989342 @default.
- W4295241432 creator A5085624794 @default.
- W4295241432 date "2022-10-01" @default.
- W4295241432 modified "2023-10-09" @default.
- W4295241432 title "Still rocking in the structural era: A molecular overview of the small multidrug resistance (SMR) transporter family" @default.
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