FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295242335> ?p ?o ?g. }

• W4295242335 endingPage "175264" @default.
• W4295242335 startingPage "175264" @default.
• W4295242335 abstract "Proteinases released e.g. during inflammatory or allergic responses affect gastrointestinal functions via proteinase-activated receptors such as PAR1 and PAR2. As the gastrointestinal tract exerts pronounced gradients along its longitudinal axis, the present study focuses on the effect of PAR1 and PAR2 agonists on electrogenic ion transport (measured as short-circuit current; Isc), tissue conductance (Gt) and contractility of the longitudinal muscle layer of rats. In Ussing chamber experiments, the PAR1 agonist TFLLR-NH2, which mimics the tethered ligand liberated after cleavage of the receptor, evoked only a modest increase in Isc (<0.5 μEq·h-1·cm-2) in small intestine, but a strong increase (3-4 μEq·h-1·cm-2) in colon. Pretreatment with tetrodotoxin reduced the response of the colonic segments to the level of the small intestine. Thrombin, the natural activator of PAR1, was much less effective suggesting biased activation by this peptidase. A similar gradient along the longitudinal axis of the intestine was observed with trypsin, the endogenous activator of PAR2. Divergent actions of PAR1 activation by enzymatic cleavage or a mimetic peptide were also observed when recording isometric contractions of longitudinal muscle. For example, in the jejunum TFLLR-NH2 concentration-dependently induced a contractile response, whereas thrombin showed only inconsistent effects. The PAR2 activator AC264613 induced a concentration-dependent decrease in muscle tone combined with an inhibition of phasic spontaneous contractions. PCR experiments and immunohistochemical stainings confirmed the expression of PAR1 and PAR2. The data implies that PAR1 and PAR2 functions vary depending on the intestinal segment." @default.
• W4295242335 created "2022-09-12" @default.
• W4295242335 creator A5075282190 @default.
• W4295242335 creator A5087200377 @default.
• W4295242335 date "2022-10-01" @default.
• W4295242335 modified "2023-10-03" @default.
• W4295242335 title "Proteinase-activated receptors regulate intestinal functions in a segment-dependent manner in rats" @default.
• W4295242335 cites W1533133853 @default.
• W4295242335 cites W1571278720 @default.
• W4295242335 cites W1795031534 @default.
• W4295242335 cites W1958081034 @default.
• W4295242335 cites W1963543751 @default.
• W4295242335 cites W1963938486 @default.
• W4295242335 cites W1970871559 @default.
• W4295242335 cites W1972713535 @default.
• W4295242335 cites W1985306734 @default.
• W4295242335 cites W1988705225 @default.
• W4295242335 cites W1999246611 @default.
• W4295242335 cites W2010931416 @default.
• W4295242335 cites W2017672336 @default.
• W4295242335 cites W2022865902 @default.
• W4295242335 cites W2028482624 @default.
• W4295242335 cites W2035602567 @default.
• W4295242335 cites W2044213158 @default.
• W4295242335 cites W2051750611 @default.
• W4295242335 cites W2069725765 @default.
• W4295242335 cites W2070602928 @default.
• W4295242335 cites W2070998066 @default.
• W4295242335 cites W2075378195 @default.
• W4295242335 cites W2075711571 @default.
• W4295242335 cites W2086196978 @default.
• W4295242335 cites W2087408808 @default.
• W4295242335 cites W2096306643 @default.
• W4295242335 cites W2111902544 @default.
• W4295242335 cites W2120415921 @default.
• W4295242335 cites W2125509406 @default.
• W4295242335 cites W2128316297 @default.
• W4295242335 cites W2166270090 @default.
• W4295242335 cites W2922607655 @default.
• W4295242335 cites W2981691120 @default.
• W4295242335 cites W3095207361 @default.
• W4295242335 cites W3137465526 @default.
• W4295242335 doi "https://doi.org/10.1016/j.ejphar.2022.175264" @default.
• W4295242335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36100127" @default.
• W4295242335 hasPublicationYear "2022" @default.
• W4295242335 type Work @default.
• W4295242335 citedByCount "3" @default.
• W4295242335 countsByYear W42952423352022 @default.
• W4295242335 countsByYear W42952423352023 @default.
• W4295242335 crossrefType "journal-article" @default.
• W4295242335 hasAuthorship W4295242335A5075282190 @default.
• W4295242335 hasAuthorship W4295242335A5087200377 @default.
• W4295242335 hasConcept C12554922 @default.
• W4295242335 hasConcept C126322002 @default.
• W4295242335 hasConcept C134018914 @default.
• W4295242335 hasConcept C170493617 @default.
• W4295242335 hasConcept C185592680 @default.
• W4295242335 hasConcept C2776741303 @default.
• W4295242335 hasConcept C2777292125 @default.
• W4295242335 hasConcept C2777882243 @default.
• W4295242335 hasConcept C2778938600 @default.
• W4295242335 hasConcept C2780880959 @default.
• W4295242335 hasConcept C2992686903 @default.
• W4295242335 hasConcept C39133596 @default.
• W4295242335 hasConcept C71924100 @default.
• W4295242335 hasConcept C86803240 @default.
• W4295242335 hasConcept C88045685 @default.
• W4295242335 hasConcept C89560881 @default.
• W4295242335 hasConceptScore W4295242335C12554922 @default.
• W4295242335 hasConceptScore W4295242335C126322002 @default.
• W4295242335 hasConceptScore W4295242335C134018914 @default.
• W4295242335 hasConceptScore W4295242335C170493617 @default.
• W4295242335 hasConceptScore W4295242335C185592680 @default.
• W4295242335 hasConceptScore W4295242335C2776741303 @default.
• W4295242335 hasConceptScore W4295242335C2777292125 @default.
• W4295242335 hasConceptScore W4295242335C2777882243 @default.
• W4295242335 hasConceptScore W4295242335C2778938600 @default.
• W4295242335 hasConceptScore W4295242335C2780880959 @default.
• W4295242335 hasConceptScore W4295242335C2992686903 @default.
• W4295242335 hasConceptScore W4295242335C39133596 @default.
• W4295242335 hasConceptScore W4295242335C71924100 @default.
• W4295242335 hasConceptScore W4295242335C86803240 @default.
• W4295242335 hasConceptScore W4295242335C88045685 @default.
• W4295242335 hasConceptScore W4295242335C89560881 @default.
• W4295242335 hasFunder F4320317182 @default.
• W4295242335 hasLocation W42952423351 @default.
• W4295242335 hasLocation W42952423352 @default.
• W4295242335 hasOpenAccess W4295242335 @default.
• W4295242335 hasPrimaryLocation W42952423351 @default.
• W4295242335 hasRelatedWork W2018368842 @default.
• W4295242335 hasRelatedWork W2027913950 @default.
• W4295242335 hasRelatedWork W2033472167 @default.
• W4295242335 hasRelatedWork W2034583712 @default.
• W4295242335 hasRelatedWork W2050423574 @default.
• W4295242335 hasRelatedWork W2058205365 @default.
• W4295242335 hasRelatedWork W2063619316 @default.
• W4295242335 hasRelatedWork W2070611629 @default.
• W4295242335 hasRelatedWork W2169225653 @default.

• next