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- W4295260246 abstract "Generalized pustular psoriasis (GPP) is a rare, potentially life-threatening autoinflammatory disease characterized by recurrent flares of sterile pustules that occur with or without systemic inflammation. The 12-week, double-blind, randomized, placebo-controlled Effisayil 1 study (NCT03782792) demonstrated that spesolimab, an anti-interleukin 36 receptor antibody, is associated with rapid pustular and skin clearance in patients with a GPP flare. Here we report the efficacy of spesolimab across prespecified patient subgroups (sex, age, race, body mass index, GPP Physician Global Assessment [GPPGA] pustulation subscore at baseline, GPPGA total score at baseline, Japanese Dermatological Association GPP severity score at baseline, plaque psoriasis at baseline, and IL-36 receptor antagonist gene mutation [IL36RN] status) in Effisayil 1." @default.
- W4295260246 created "2022-09-12" @default.
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- W4295260246 date "2022-09-01" @default.
- W4295260246 modified "2023-09-30" @default.
- W4295260246 title "33007 Efficacy of spesolimab for the treatment of GPP flares across prespecified patient subgroups in the Effisayil 1 study" @default.
- W4295260246 doi "https://doi.org/10.1016/j.jaad.2022.06.248" @default.
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