Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295279966> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4295279966 endingPage "S75" @default.
- W4295279966 startingPage "S75" @default.
- W4295279966 abstract "The study aims to evaluate the impact of genetic, demographic and clinical data on various measures of outcome of anticoagulation quality in patients.The study consisted of 310 patients receiving long-term oral anticoagulation therapy in our hospital. Apart from demographic and clinical variables, 21 SNPs (in 7 genes) were analyzed and compared with the outcomes of anticoagulation therapy. Various outcomes that were measured are; supra therapeutic INRs (INR >3, >6), anticoagulation stabilization, time taken to stabilize and proportion of INRs within (2–3), above (>3) and below (<2) therapeutic range.Supra therapeutic INRs were influenced by CYP2C9*2, *3, CYP4F2 rs2108622, VKORC1-1639G>A, 1173C>T, rs55894764 along with concomitant drugs, smoking, body weight and height. Persistently fluctuating INRs/absolute instability correlated with VKORC1-1639G>A, gender, height and body mass index. The time taken to stabilize was associated with CYP4F2 rs2108622, CYP2C9*14, smoking, clinical indication and concomitant drugs. The overall distribution of INR was influenced by variants in CYP4F2 rs2108622, CYP2C9*3, rs9332230, VKORC1 1173C>T, −1639G>A, rs55894764, ABCB1 rs2032582, rs1128503, rs1045642 and F5 rs6025, age, smoking and concomitant drugs.Knowledge of factors influencing the quality of long term anticoagulation can help clinicians to customize therapy either by dose variation, therapy with alternate choice of drug, concurrent heparin therapy and/or frequent INR monitoring." @default.
- W4295279966 created "2022-09-12" @default.
- W4295279966 creator A5001046709 @default.
- W4295279966 creator A5002611817 @default.
- W4295279966 creator A5005892556 @default.
- W4295279966 creator A5009777481 @default.
- W4295279966 creator A5032482857 @default.
- W4295279966 creator A5063707693 @default.
- W4295279966 creator A5066466280 @default.
- W4295279966 creator A5071968055 @default.
- W4295279966 date "2022-09-01" @default.
- W4295279966 modified "2023-09-25" @default.
- W4295279966 title "SOC-VI-04 A new suite of media for cardiotoxicity and drug discovery studies with human iPSC-derived cardiomyocytes" @default.
- W4295279966 doi "https://doi.org/10.1016/j.toxlet.2022.07.224" @default.
- W4295279966 hasPublicationYear "2022" @default.
- W4295279966 type Work @default.
- W4295279966 citedByCount "0" @default.
- W4295279966 crossrefType "journal-article" @default.
- W4295279966 hasAuthorship W4295279966A5001046709 @default.
- W4295279966 hasAuthorship W4295279966A5002611817 @default.
- W4295279966 hasAuthorship W4295279966A5005892556 @default.
- W4295279966 hasAuthorship W4295279966A5009777481 @default.
- W4295279966 hasAuthorship W4295279966A5032482857 @default.
- W4295279966 hasAuthorship W4295279966A5063707693 @default.
- W4295279966 hasAuthorship W4295279966A5066466280 @default.
- W4295279966 hasAuthorship W4295279966A5071968055 @default.
- W4295279966 hasConcept C102652120 @default.
- W4295279966 hasConcept C104317684 @default.
- W4295279966 hasConcept C126322002 @default.
- W4295279966 hasConcept C135763542 @default.
- W4295279966 hasConcept C177713679 @default.
- W4295279966 hasConcept C185592680 @default.
- W4295279966 hasConcept C19831878 @default.
- W4295279966 hasConcept C2776318485 @default.
- W4295279966 hasConcept C2779384505 @default.
- W4295279966 hasConcept C2780035454 @default.
- W4295279966 hasConcept C2780272996 @default.
- W4295279966 hasConcept C3946865 @default.
- W4295279966 hasConcept C4441509 @default.
- W4295279966 hasConcept C500440147 @default.
- W4295279966 hasConcept C526171541 @default.
- W4295279966 hasConcept C55493867 @default.
- W4295279966 hasConcept C55775858 @default.
- W4295279966 hasConcept C62231903 @default.
- W4295279966 hasConcept C71924100 @default.
- W4295279966 hasConcept C98274493 @default.
- W4295279966 hasConceptScore W4295279966C102652120 @default.
- W4295279966 hasConceptScore W4295279966C104317684 @default.
- W4295279966 hasConceptScore W4295279966C126322002 @default.
- W4295279966 hasConceptScore W4295279966C135763542 @default.
- W4295279966 hasConceptScore W4295279966C177713679 @default.
- W4295279966 hasConceptScore W4295279966C185592680 @default.
- W4295279966 hasConceptScore W4295279966C19831878 @default.
- W4295279966 hasConceptScore W4295279966C2776318485 @default.
- W4295279966 hasConceptScore W4295279966C2779384505 @default.
- W4295279966 hasConceptScore W4295279966C2780035454 @default.
- W4295279966 hasConceptScore W4295279966C2780272996 @default.
- W4295279966 hasConceptScore W4295279966C3946865 @default.
- W4295279966 hasConceptScore W4295279966C4441509 @default.
- W4295279966 hasConceptScore W4295279966C500440147 @default.
- W4295279966 hasConceptScore W4295279966C526171541 @default.
- W4295279966 hasConceptScore W4295279966C55493867 @default.
- W4295279966 hasConceptScore W4295279966C55775858 @default.
- W4295279966 hasConceptScore W4295279966C62231903 @default.
- W4295279966 hasConceptScore W4295279966C71924100 @default.
- W4295279966 hasConceptScore W4295279966C98274493 @default.
- W4295279966 hasLocation W42952799661 @default.
- W4295279966 hasOpenAccess W4295279966 @default.
- W4295279966 hasPrimaryLocation W42952799661 @default.
- W4295279966 hasRelatedWork W2006640042 @default.
- W4295279966 hasRelatedWork W2025668168 @default.
- W4295279966 hasRelatedWork W2059587305 @default.
- W4295279966 hasRelatedWork W2080489638 @default.
- W4295279966 hasRelatedWork W2127180533 @default.
- W4295279966 hasRelatedWork W2147207746 @default.
- W4295279966 hasRelatedWork W2282667685 @default.
- W4295279966 hasRelatedWork W2937586098 @default.
- W4295279966 hasRelatedWork W4256571634 @default.
- W4295279966 hasRelatedWork W4308718735 @default.
- W4295279966 hasVolume "368" @default.
- W4295279966 isParatext "false" @default.
- W4295279966 isRetracted "false" @default.
- W4295279966 workType "article" @default.