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- W4295280370 abstract "Allergic diseases remain to be a substantial socioeconomic burden with increasing prevalence worldwide. Despite considerable efforts to identify safe and effective treatment, the lack of validated biomarkers and the existence of a complex disease phenotype and endotype remains the main challenge to advance precision medicine. Understanding the immunological and molecular mechanisms underlying the development of allergic diseases and pathways that drive immune tolerance is crucial in designing therapeutic approaches for treating allergic diseases. At present, allergen-specific immunotherapy and biologicals that target key molecules driving type-2 response (IgE, IL-4, IL-5 and IL-13) are used in the clinic. A few other candidate drugs and a combination of biologics as an adjunct to allergen immunotherapy are currently being tested in clinical trials to assess their safety and efficacy. This chapter describes the underpinning mechanisms of allergic diseases and associated therapeutic options available in the clinic, focusing on asthma, atopic dermatitis, chronic rhinosinusitis, and allergic rhinitis." @default.
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- W4295280370 date "2022-09-01" @default.
- W4295280370 modified "2023-09-25" @default.
- W4295280370 title "P10-15 Novel immunotoxicological implications of methylisothiazolinone" @default.
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- W4295280370 doi "https://doi.org/10.1016/j.toxlet.2022.07.446" @default.
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