Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295280472> ?p ?o ?g. }
- W4295280472 abstract "Juvenile myelomonocytic leukemia (JMML) is a rare and aggressive clonal neoplasm of early childhood, classified as an overlap myeloproliferative/myelodysplastic neoplasm by the World Health Organization. In 90% of the patients with JMML, typical initiating mutations in the canonical Ras pathway genes NF1, PTPN11, NRAS, KRAS, and CBL can be identified. Hematopoietic stem cell transplantation (HSCT) currently is the established standard of care in most patients, although long-term survival is still only 50-60%. Given the limited therapeutic options and the important morbidity and mortality associated with HSCT, new therapeutic approaches are urgently needed. Hyperactivation of the Ras pathway as disease mechanism in JMML lends itself to the use of targeted therapy. Targeted therapy could play an important role in the future treatment of patients with JMML. This review presents a comprehensive overview of targeted therapies already developed and evaluated in vitro and in vivo in patients with JMML." @default.
- W4295280472 created "2022-09-12" @default.
- W4295280472 creator A5011582886 @default.
- W4295280472 creator A5015213142 @default.
- W4295280472 creator A5020166032 @default.
- W4295280472 creator A5035136306 @default.
- W4295280472 creator A5055956862 @default.
- W4295280472 creator A5071534196 @default.
- W4295280472 date "2022-09-12" @default.
- W4295280472 modified "2023-10-05" @default.
- W4295280472 title "Targeted therapy in juvenile myelomonocytic leukemia: Where are we now?" @default.
- W4295280472 cites W1534632891 @default.
- W4295280472 cites W1914707730 @default.
- W4295280472 cites W1948939232 @default.
- W4295280472 cites W1956698747 @default.
- W4295280472 cites W1967938842 @default.
- W4295280472 cites W1971730089 @default.
- W4295280472 cites W1972960063 @default.
- W4295280472 cites W1974901078 @default.
- W4295280472 cites W1977420876 @default.
- W4295280472 cites W1978348660 @default.
- W4295280472 cites W1980861909 @default.
- W4295280472 cites W1993428519 @default.
- W4295280472 cites W1994491427 @default.
- W4295280472 cites W1996635414 @default.
- W4295280472 cites W2011653532 @default.
- W4295280472 cites W2012502710 @default.
- W4295280472 cites W2013486506 @default.
- W4295280472 cites W2015891269 @default.
- W4295280472 cites W2018675795 @default.
- W4295280472 cites W2022951324 @default.
- W4295280472 cites W2025762987 @default.
- W4295280472 cites W2026567689 @default.
- W4295280472 cites W2029020524 @default.
- W4295280472 cites W2033164620 @default.
- W4295280472 cites W2033231966 @default.
- W4295280472 cites W2046493188 @default.
- W4295280472 cites W2047417247 @default.
- W4295280472 cites W2048864213 @default.
- W4295280472 cites W2077730236 @default.
- W4295280472 cites W2080153074 @default.
- W4295280472 cites W2081990599 @default.
- W4295280472 cites W2082448876 @default.
- W4295280472 cites W2086286404 @default.
- W4295280472 cites W2099896338 @default.
- W4295280472 cites W2112461562 @default.
- W4295280472 cites W2115951444 @default.
- W4295280472 cites W2128855114 @default.
- W4295280472 cites W2136157904 @default.
- W4295280472 cites W2139017293 @default.
- W4295280472 cites W2139813696 @default.
- W4295280472 cites W2149941857 @default.
- W4295280472 cites W2153571501 @default.
- W4295280472 cites W2154148265 @default.
- W4295280472 cites W2155265055 @default.
- W4295280472 cites W2159659449 @default.
- W4295280472 cites W2162079601 @default.
- W4295280472 cites W2261929084 @default.
- W4295280472 cites W2267858353 @default.
- W4295280472 cites W2290201733 @default.
- W4295280472 cites W2294083716 @default.
- W4295280472 cites W2296905683 @default.
- W4295280472 cites W2300527602 @default.
- W4295280472 cites W2339828620 @default.
- W4295280472 cites W2461775944 @default.
- W4295280472 cites W2465069143 @default.
- W4295280472 cites W2502200489 @default.
- W4295280472 cites W2514569171 @default.
- W4295280472 cites W2541514381 @default.
- W4295280472 cites W2549616071 @default.
- W4295280472 cites W2553071293 @default.
- W4295280472 cites W2594515725 @default.
- W4295280472 cites W2626578199 @default.
- W4295280472 cites W2671535368 @default.
- W4295280472 cites W2750874984 @default.
- W4295280472 cites W2754551124 @default.
- W4295280472 cites W2764264230 @default.
- W4295280472 cites W2767308221 @default.
- W4295280472 cites W2767759463 @default.
- W4295280472 cites W2771407369 @default.
- W4295280472 cites W2775315173 @default.
- W4295280472 cites W2775445984 @default.
- W4295280472 cites W2787217613 @default.
- W4295280472 cites W2805416487 @default.
- W4295280472 cites W2806742248 @default.
- W4295280472 cites W2897527318 @default.
- W4295280472 cites W2908000794 @default.
- W4295280472 cites W2912035047 @default.
- W4295280472 cites W2920795131 @default.
- W4295280472 cites W2936399310 @default.
- W4295280472 cites W2940793077 @default.
- W4295280472 cites W2973166943 @default.
- W4295280472 cites W2989790222 @default.
- W4295280472 cites W3010967763 @default.
- W4295280472 cites W3014882016 @default.
- W4295280472 cites W3015232258 @default.
- W4295280472 cites W3029948889 @default.
- W4295280472 cites W3108156605 @default.
- W4295280472 cites W3119269459 @default.
- W4295280472 cites W3120048232 @default.