Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295280487> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W4295280487 endingPage "S157" @default.
- W4295280487 startingPage "S157" @default.
- W4295280487 abstract "In France, part of the population is overexposed to cadmium by the diet.In our work, we first revised the tolerable daily intake (TDI) of 0.36 μg Cd.kg bw.d.−1 proposed by the European Food Safety Authority (EFSA), derived from effects on kidneys and based on the critical urinary Cd concentration of 1.0 μg Cd.g−1 creatinine for humans.After reviewing the epidemiological data on Cd toxicity published after 2011, bone effects were selected as the critical effects. Body burden data of 0.5 μg.g−1 creatinine was chosen for the critical threshold for human urinary cadmium concentrations.To be used for the derivation of the new oral toxicological reference value, we used a modified physiologically based pharmacokinetic model (PBPK). The reverse calculation on the PBPK model gave a TDI of 0.35 μg Cd.kg bw−1.day−1.This TDI is compatible with a urinary Cd concentrations not exceeding 0.5 μg Cd.g−1 creatinine, in a 60 year-old adult, assuming that ingestion is the only source of exposure to Cd at 60 years. After implementing the PBPK model with French physiological data, Cd biological reference values as a function of age were modelled so as to remain below the revised health-based guidance values." @default.
- W4295280487 created "2022-09-12" @default.
- W4295280487 creator A5003030995 @default.
- W4295280487 creator A5004184841 @default.
- W4295280487 creator A5012015535 @default.
- W4295280487 creator A5021144033 @default.
- W4295280487 creator A5030492172 @default.
- W4295280487 creator A5034221185 @default.
- W4295280487 creator A5050728537 @default.
- W4295280487 creator A5058745306 @default.
- W4295280487 creator A5076166520 @default.
- W4295280487 creator A5078281525 @default.
- W4295280487 creator A5078674006 @default.
- W4295280487 date "2022-09-01" @default.
- W4295280487 modified "2023-09-25" @default.
- W4295280487 title "P10-07 A multivariate approach to identify food compounds that affect immune-mediated inflammatory disease course" @default.
- W4295280487 doi "https://doi.org/10.1016/j.toxlet.2022.07.438" @default.
- W4295280487 hasPublicationYear "2022" @default.
- W4295280487 type Work @default.
- W4295280487 citedByCount "0" @default.
- W4295280487 crossrefType "journal-article" @default.
- W4295280487 hasAuthorship W4295280487A5003030995 @default.
- W4295280487 hasAuthorship W4295280487A5004184841 @default.
- W4295280487 hasAuthorship W4295280487A5012015535 @default.
- W4295280487 hasAuthorship W4295280487A5021144033 @default.
- W4295280487 hasAuthorship W4295280487A5030492172 @default.
- W4295280487 hasAuthorship W4295280487A5034221185 @default.
- W4295280487 hasAuthorship W4295280487A5050728537 @default.
- W4295280487 hasAuthorship W4295280487A5058745306 @default.
- W4295280487 hasAuthorship W4295280487A5076166520 @default.
- W4295280487 hasAuthorship W4295280487A5078281525 @default.
- W4295280487 hasAuthorship W4295280487A5078674006 @default.
- W4295280487 hasConcept C112705442 @default.
- W4295280487 hasConcept C126322002 @default.
- W4295280487 hasConcept C185592680 @default.
- W4295280487 hasConcept C185867374 @default.
- W4295280487 hasConcept C193230392 @default.
- W4295280487 hasConcept C203014093 @default.
- W4295280487 hasConcept C2780306776 @default.
- W4295280487 hasConcept C2908647359 @default.
- W4295280487 hasConcept C33070731 @default.
- W4295280487 hasConcept C42407357 @default.
- W4295280487 hasConcept C71924100 @default.
- W4295280487 hasConcept C77411442 @default.
- W4295280487 hasConcept C86803240 @default.
- W4295280487 hasConcept C8891405 @default.
- W4295280487 hasConcept C98274493 @default.
- W4295280487 hasConcept C99454951 @default.
- W4295280487 hasConceptScore W4295280487C112705442 @default.
- W4295280487 hasConceptScore W4295280487C126322002 @default.
- W4295280487 hasConceptScore W4295280487C185592680 @default.
- W4295280487 hasConceptScore W4295280487C185867374 @default.
- W4295280487 hasConceptScore W4295280487C193230392 @default.
- W4295280487 hasConceptScore W4295280487C203014093 @default.
- W4295280487 hasConceptScore W4295280487C2780306776 @default.
- W4295280487 hasConceptScore W4295280487C2908647359 @default.
- W4295280487 hasConceptScore W4295280487C33070731 @default.
- W4295280487 hasConceptScore W4295280487C42407357 @default.
- W4295280487 hasConceptScore W4295280487C71924100 @default.
- W4295280487 hasConceptScore W4295280487C77411442 @default.
- W4295280487 hasConceptScore W4295280487C86803240 @default.
- W4295280487 hasConceptScore W4295280487C8891405 @default.
- W4295280487 hasConceptScore W4295280487C98274493 @default.
- W4295280487 hasConceptScore W4295280487C99454951 @default.
- W4295280487 hasLocation W42952804871 @default.
- W4295280487 hasOpenAccess W4295280487 @default.
- W4295280487 hasPrimaryLocation W42952804871 @default.
- W4295280487 hasRelatedWork W1499958231 @default.
- W4295280487 hasRelatedWork W2000200648 @default.
- W4295280487 hasRelatedWork W2068005011 @default.
- W4295280487 hasRelatedWork W2293351877 @default.
- W4295280487 hasRelatedWork W2956596586 @default.
- W4295280487 hasRelatedWork W3212117736 @default.
- W4295280487 hasRelatedWork W4206966109 @default.
- W4295280487 hasRelatedWork W4307092588 @default.
- W4295280487 hasRelatedWork W4308352595 @default.
- W4295280487 hasRelatedWork W4309723377 @default.
- W4295280487 hasVolume "368" @default.
- W4295280487 isParatext "false" @default.
- W4295280487 isRetracted "false" @default.
- W4295280487 workType "article" @default.