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- W4295290338 abstract "The dynamics of adaptation is difficult to predict because it is highly stochastic even in large populations. The uncertainty emerges from number fluctuations, called genetic drift, arising in the small number of particularly fit individuals of the population. Random genetic drift in this evolutionary vanguard also limits the speed of adaptation, which diverges in deterministic models that ignore these chance effects. Several approaches have been developed to analyze the crucial role of noise on the expected dynamics of adaptation, including the mean fitness of the entire population, or the fate of newly arising beneficial deleterious mutations. However, very little is known about how genetic drift causes fluctuations to emerge on the population level, including fitness distribution variations and speed variations. Yet, these phenomena control the replicability of experimental evolution experiments and are key to a truly predictive understanding of evolutionary processes. Here, we develop an exact approach to these emergent fluctuations by a combination of computational and analytical methods. We show, analytically, that the infinite hierarchy of moment equations can be closed at any arbitrary order by a suitable choice of a dynamical constraint. This constraint regulates (rather than fixes) the population size, accounting for resource limitations. The resulting linear equations, which can be accurately solved numerically, exhibit fluctuation-induced terms that amplify short-distance correlations and suppress long-distance ones. Importantly, by accounting for the dynamics of sub-populations, we provide a systematic route to key population genetic quantities, such as fixation probabilities and decay rates of the genetic diversity." @default.
- W4295290338 created "2022-09-12" @default.
- W4295290338 creator A5039329500 @default.
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- W4295290338 date "2015-06-29" @default.
- W4295290338 modified "2023-10-14" @default.
- W4295290338 title "Collective Fluctuations in models of adaptation" @default.
- W4295290338 doi "https://doi.org/10.48550/arxiv.1506.08683" @default.
- W4295290338 hasPublicationYear "2015" @default.
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