FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295300851> ?p ?o ?g. }

• W4295300851 abstract "In mammals, the medio-basal hypothalamus (MBH) integrates photoperiodic and food-related cues to ensure timely phasing of physiological functions, including seasonal reproduction. The current human epidemics of obesity and associated reproductive disorders exemplifies the tight link between metabolism and reproduction. Yet, how food-related cues impact breeding at the level of the MBH remains unclear. In this respect, the sheep, which is a large diurnal mammal with a marked dual photoperiodic/metabolic control of seasonal breeding, is a relevant model. Here, we present a large-scale study in ewes (n = 120), which investigated the impact of food restriction (FRes) on the MBH transcriptome using unbiased RNAseq, followed by RT-qPCR. Few genes (~100) were impacted by FRes and the transcriptional impact was very modest (<2-fold increase or < 50% decrease for most genes). As anticipated, FRes increased expression of Npy/AgRP/LepR and decreased expression of Pomc/Cartpt, while Kiss1 expression was not impacted. Of particular interest, Eya3, Nmu and Dio2, genes involved in photoperiodic decoding within the MBH, were also affected by FRes. Finally, we also identified a handful of genes not known to be regulated by food-related cues (e.g., RNase6, HspA6, Arrdc2). In conclusion, our transcriptomics study provides insights into the impact of metabolism on the MBH in sheep, which may be relevant to human, and identifies possible molecular links between metabolism and (seasonal) reproduction." @default.
• W4295300851 created "2022-09-12" @default.
• W4295300851 creator A5002459200 @default.
• W4295300851 creator A5011229637 @default.
• W4295300851 creator A5015545254 @default.
• W4295300851 creator A5020978823 @default.
• W4295300851 creator A5053592495 @default.
• W4295300851 creator A5056203538 @default.
• W4295300851 creator A5060675130 @default.
• W4295300851 creator A5068054114 @default.
• W4295300851 creator A5083459269 @default.
• W4295300851 date "2022-09-27" @default.
• W4295300851 modified "2023-10-14" @default.
• W4295300851 title "Impact of food restriction on the medio‐basal hypothalamus of intact ewes as revealed by a large‐scale transcriptomics study" @default.
• W4295300851 cites W1488526962 @default.
• W4295300851 cites W1489541636 @default.
• W4295300851 cites W1497258232 @default.
• W4295300851 cites W1533247494 @default.
• W4295300851 cites W1561443084 @default.
• W4295300851 cites W1752979881 @default.
• W4295300851 cites W1852617263 @default.
• W4295300851 cites W1907591936 @default.
• W4295300851 cites W1936850650 @default.
• W4295300851 cites W1974677042 @default.
• W4295300851 cites W1979001866 @default.
• W4295300851 cites W1979686271 @default.
• W4295300851 cites W1987692557 @default.
• W4295300851 cites W1988377203 @default.
• W4295300851 cites W1998422932 @default.
• W4295300851 cites W2001746592 @default.
• W4295300851 cites W2005121205 @default.
• W4295300851 cites W2005744729 @default.
• W4295300851 cites W2007323874 @default.
• W4295300851 cites W2008628402 @default.
• W4295300851 cites W2013426794 @default.
• W4295300851 cites W2017275238 @default.
• W4295300851 cites W2024749335 @default.
• W4295300851 cites W2025295789 @default.
• W4295300851 cites W2031374608 @default.
• W4295300851 cites W2034810986 @default.
• W4295300851 cites W2035089406 @default.
• W4295300851 cites W2035387017 @default.
• W4295300851 cites W2051081976 @default.
• W4295300851 cites W2056044816 @default.
• W4295300851 cites W2057182280 @default.
• W4295300851 cites W2061750855 @default.
• W4295300851 cites W2062566674 @default.
• W4295300851 cites W2066860383 @default.
• W4295300851 cites W2068597583 @default.
• W4295300851 cites W2069091630 @default.
• W4295300851 cites W2070995469 @default.
• W4295300851 cites W2075928570 @default.
• W4295300851 cites W2076254702 @default.
• W4295300851 cites W2084810464 @default.
• W4295300851 cites W2092587480 @default.
• W4295300851 cites W2094842041 @default.
• W4295300851 cites W2096274244 @default.
• W4295300851 cites W2098110093 @default.
• W4295300851 cites W2098917312 @default.
• W4295300851 cites W2099132537 @default.
• W4295300851 cites W2100028600 @default.
• W4295300851 cites W2105010380 @default.
• W4295300851 cites W2106488618 @default.
• W4295300851 cites W2111548329 @default.
• W4295300851 cites W2114104545 @default.
• W4295300851 cites W2121637377 @default.
• W4295300851 cites W2122129260 @default.
• W4295300851 cites W2122178234 @default.
• W4295300851 cites W2122184385 @default.
• W4295300851 cites W2124985265 @default.
• W4295300851 cites W2125333644 @default.
• W4295300851 cites W2132603015 @default.
• W4295300851 cites W2133258169 @default.
• W4295300851 cites W2136506742 @default.
• W4295300851 cites W2138207763 @default.
• W4295300851 cites W2138785172 @default.
• W4295300851 cites W2140729960 @default.
• W4295300851 cites W2141532080 @default.
• W4295300851 cites W2142208562 @default.
• W4295300851 cites W2143227010 @default.
• W4295300851 cites W2143829406 @default.
• W4295300851 cites W2153447730 @default.
• W4295300851 cites W2158812746 @default.
• W4295300851 cites W2159392554 @default.
• W4295300851 cites W2160697532 @default.
• W4295300851 cites W2170841041 @default.
• W4295300851 cites W2179438025 @default.
• W4295300851 cites W2288161969 @default.
• W4295300851 cites W2340417327 @default.
• W4295300851 cites W2509201575 @default.
• W4295300851 cites W2511884923 @default.
• W4295300851 cites W2517314869 @default.
• W4295300851 cites W2518498264 @default.
• W4295300851 cites W2546713947 @default.
• W4295300851 cites W2588381980 @default.
• W4295300851 cites W2764091087 @default.
• W4295300851 cites W2790193528 @default.
• W4295300851 cites W2794061735 @default.
• W4295300851 cites W2794578082 @default.
• W4295300851 cites W2800142137 @default.

• next