FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295332810> ?p ?o ?g. }

• W4295332810 endingPage "8995" @default.
• W4295332810 startingPage "8987" @default.
• W4295332810 abstract "In spite of the recognition that striatal D 2 receptors are critical determinants in a variety of psychomotor disorders, the cellular mechanisms by which these receptors shape neuronal activity have remained a mystery. The studies presented here reveal that D 2 receptor stimulation in enkephalin-expressing medium spiny neurons suppresses transmembrane Ca 2+ currents through L-type Ca 2+ channels, resulting in diminished excitability. This modulation is mediated by G β γ activation of phospholipase C, mobilization of intracellular Ca 2+ stores, and activation of the calcium-dependent phosphatase calcineurin. In addition to providing a unifying mechanism to explain the apparently divergent effects of D 2 receptors in striatal medium spiny neurons, this novel signaling linkage provides a foundation for understanding how this pivotal receptor shapes striatal excitability and gene expression." @default.
• W4295332810 created "2022-09-13" @default.
• W4295332810 creator A5005081394 @default.
• W4295332810 creator A5022991808 @default.
• W4295332810 creator A5023618339 @default.
• W4295332810 creator A5033742239 @default.
• W4295332810 creator A5036093129 @default.
• W4295332810 creator A5047816837 @default.
• W4295332810 creator A5064791807 @default.
• W4295332810 date "2000-12-15" @default.
• W4295332810 modified "2023-10-14" @default.
• W4295332810 title "D₂Dopamine Receptors in Striatal Medium Spiny Neurons Reduce L-Type Ca²⁺Currents and Excitability via a Novel PLCβ1–IP₃–Calcineurin-Signaling Cascade" @default.
• W4295332810 cites W1008413412 @default.
• W4295332810 cites W1486039058 @default.
• W4295332810 cites W1493922075 @default.
• W4295332810 cites W1499439697 @default.
• W4295332810 cites W1519847602 @default.
• W4295332810 cites W1543271211 @default.
• W4295332810 cites W1554714271 @default.
• W4295332810 cites W1567627398 @default.
• W4295332810 cites W1643093152 @default.
• W4295332810 cites W1919086687 @default.
• W4295332810 cites W1943789780 @default.
• W4295332810 cites W1945424073 @default.
• W4295332810 cites W1946415498 @default.
• W4295332810 cites W1958547196 @default.
• W4295332810 cites W1967463041 @default.
• W4295332810 cites W1971795615 @default.
• W4295332810 cites W1971809347 @default.
• W4295332810 cites W1981182586 @default.
• W4295332810 cites W1981891173 @default.
• W4295332810 cites W1987453093 @default.
• W4295332810 cites W1992347253 @default.
• W4295332810 cites W1998763917 @default.
• W4295332810 cites W1999772524 @default.
• W4295332810 cites W2016859552 @default.
• W4295332810 cites W2021148197 @default.
• W4295332810 cites W2025961985 @default.
• W4295332810 cites W2029704856 @default.
• W4295332810 cites W2037261940 @default.
• W4295332810 cites W2040631469 @default.
• W4295332810 cites W2040867705 @default.
• W4295332810 cites W2041563380 @default.
• W4295332810 cites W2048280515 @default.
• W4295332810 cites W2060588252 @default.
• W4295332810 cites W2063987551 @default.
• W4295332810 cites W2073715142 @default.
• W4295332810 cites W2075720274 @default.
• W4295332810 cites W2077102671 @default.
• W4295332810 cites W2087062865 @default.
• W4295332810 cites W2088264073 @default.
• W4295332810 cites W2091897843 @default.
• W4295332810 cites W2092109656 @default.
• W4295332810 cites W2101811790 @default.
• W4295332810 cites W2108064579 @default.
• W4295332810 cites W2118938877 @default.
• W4295332810 cites W2122946342 @default.
• W4295332810 cites W2125023393 @default.
• W4295332810 cites W2145594774 @default.
• W4295332810 cites W2147917606 @default.
• W4295332810 cites W2155599139 @default.
• W4295332810 cites W2160146943 @default.
• W4295332810 cites W2162836351 @default.
• W4295332810 cites W2163462619 @default.
• W4295332810 cites W2164060165 @default.
• W4295332810 cites W2340510052 @default.
• W4295332810 cites W2340994737 @default.
• W4295332810 doi "https://doi.org/10.1523/jneurosci.20-24-08987.2000" @default.
• W4295332810 hasPublicationYear "2000" @default.
• W4295332810 type Work @default.
• W4295332810 citedByCount "390" @default.
• W4295332810 countsByYear W42953328102012 @default.
• W4295332810 countsByYear W42953328102013 @default.
• W4295332810 countsByYear W42953328102014 @default.
• W4295332810 countsByYear W42953328102015 @default.
• W4295332810 countsByYear W42953328102016 @default.
• W4295332810 countsByYear W42953328102017 @default.
• W4295332810 countsByYear W42953328102018 @default.
• W4295332810 countsByYear W42953328102019 @default.
• W4295332810 countsByYear W42953328102020 @default.
• W4295332810 countsByYear W42953328102021 @default.
• W4295332810 countsByYear W42953328102022 @default.
• W4295332810 countsByYear W42953328102023 @default.
• W4295332810 crossrefType "journal-article" @default.
• W4295332810 hasAuthorship W4295332810A5005081394 @default.
• W4295332810 hasAuthorship W4295332810A5022991808 @default.
• W4295332810 hasAuthorship W4295332810A5023618339 @default.
• W4295332810 hasAuthorship W4295332810A5033742239 @default.
• W4295332810 hasAuthorship W4295332810A5036093129 @default.
• W4295332810 hasAuthorship W4295332810A5047816837 @default.
• W4295332810 hasAuthorship W4295332810A5064791807 @default.
• W4295332810 hasBestOaLocation W42953328101 @default.
• W4295332810 hasConcept C126322002 @default.
• W4295332810 hasConcept C128057223 @default.
• W4295332810 hasConcept C169760540 @default.
• W4295332810 hasConcept C170493617 @default.
• W4295332810 hasConcept C185592680 @default.
• W4295332810 hasConcept C201571599 @default.

• next