Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295346231> ?p ?o ?g. }
- W4295346231 abstract "Green chemistry has been a growing multidisciplinary field in recent years showing great promise in biomedical applications, especially for cancer therapy. Chitosan (CS) is an abundant biopolymer derived from chitin and is present in insects and fungi. This polysaccharide has favorable characteristics, including biocompatibility, biodegradability, and ease of modification by enzymes and chemicals. CS-based nanoparticles (CS-NPs) have shown potential in the treatment of cancer and other diseases, affording targeted delivery and overcoming drug resistance. The current review emphasizes on the application of CS-NPs for the delivery of a chemotherapeutic agent, doxorubicin (DOX), in cancer therapy as they promote internalization of DOX in cancer cells and prevent the activity of P-glycoprotein (P-gp) to reverse drug resistance. These nanoarchitectures can provide co-delivery of DOX with antitumor agents such as curcumin and cisplatin to induce synergistic cancer therapy. Furthermore, co-loading of DOX with siRNA, shRNA, and miRNA can suppress tumor progression and provide chemosensitivity. Various nanostructures, including lipid-, carbon-, polymeric- and metal-based nanoparticles, are modifiable with CS for DOX delivery, while functionalization of CS-NPs with ligands such as hyaluronic acid promotes selectivity toward tumor cells and prevents DOX resistance. The CS-NPs demonstrate high encapsulation efficiency and due to protonation of amine groups of CS, pH-sensitive release of DOX can occur. Furthermore, redox- and light-responsive CS-NPs have been prepared for DOX delivery in cancer treatment. Leveraging these characteristics and in view of the biocompatibility of CS-NPs, we expect to soon see significant progress towards clinical translation." @default.
- W4295346231 created "2022-09-13" @default.
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- W4295346231 date "2022-09-13" @default.
- W4295346231 modified "2023-10-16" @default.
- W4295346231 title "Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy" @default.
- W4295346231 cites W125325141 @default.
- W4295346231 cites W1556699801 @default.
- W4295346231 cites W1577955674 @default.
- W4295346231 cites W1827886703 @default.
- W4295346231 cites W1962400655 @default.
- W4295346231 cites W1971235077 @default.
- W4295346231 cites W1976073542 @default.
- W4295346231 cites W1988181323 @default.
- W4295346231 cites W1992172691 @default.
- W4295346231 cites W1995269365 @default.
- W4295346231 cites W1996169268 @default.
- W4295346231 cites W1996434404 @default.
- W4295346231 cites W1998804638 @default.
- W4295346231 cites W2001286327 @default.
- W4295346231 cites W2005475049 @default.
- W4295346231 cites W2006178567 @default.
- W4295346231 cites W2007084311 @default.
- W4295346231 cites W2010693773 @default.
- W4295346231 cites W2015731158 @default.
- W4295346231 cites W2023135059 @default.
- W4295346231 cites W2024313626 @default.
- W4295346231 cites W2025538812 @default.
- W4295346231 cites W2026087821 @default.
- W4295346231 cites W2028273450 @default.
- W4295346231 cites W2028440673 @default.
- W4295346231 cites W2034337909 @default.
- W4295346231 cites W2034735099 @default.
- W4295346231 cites W2035554303 @default.
- W4295346231 cites W2038492285 @default.
- W4295346231 cites W2043730894 @default.
- W4295346231 cites W2046161634 @default.
- W4295346231 cites W2046872866 @default.
- W4295346231 cites W2050165248 @default.
- W4295346231 cites W2052909312 @default.
- W4295346231 cites W2054389283 @default.
- W4295346231 cites W2057437358 @default.
- W4295346231 cites W2060493851 @default.
- W4295346231 cites W2061946144 @default.
- W4295346231 cites W2065307591 @default.
- W4295346231 cites W2066685510 @default.
- W4295346231 cites W2066854206 @default.
- W4295346231 cites W2070003597 @default.
- W4295346231 cites W2070882593 @default.
- W4295346231 cites W2074332174 @default.
- W4295346231 cites W2076257412 @default.
- W4295346231 cites W2078362380 @default.
- W4295346231 cites W2078497956 @default.
- W4295346231 cites W2079745748 @default.
- W4295346231 cites W2082483448 @default.
- W4295346231 cites W2092211531 @default.
- W4295346231 cites W2094505929 @default.
- W4295346231 cites W2102897174 @default.
- W4295346231 cites W2108031998 @default.
- W4295346231 cites W2113000309 @default.
- W4295346231 cites W2122189144 @default.
- W4295346231 cites W2187976253 @default.
- W4295346231 cites W2191069130 @default.
- W4295346231 cites W2275423927 @default.
- W4295346231 cites W2295551492 @default.
- W4295346231 cites W2312918928 @default.
- W4295346231 cites W2314247704 @default.
- W4295346231 cites W2324775542 @default.
- W4295346231 cites W2342688896 @default.
- W4295346231 cites W2344782712 @default.
- W4295346231 cites W2396747981 @default.
- W4295346231 cites W2399871982 @default.
- W4295346231 cites W2401017356 @default.
- W4295346231 cites W2422895798 @default.
- W4295346231 cites W2460673741 @default.
- W4295346231 cites W2471749719 @default.
- W4295346231 cites W2474467932 @default.
- W4295346231 cites W2508978412 @default.
- W4295346231 cites W2519207192 @default.
- W4295346231 cites W2521884293 @default.
- W4295346231 cites W2522736481 @default.
- W4295346231 cites W2536737910 @default.
- W4295346231 cites W2549900055 @default.