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• W4295346253 abstract "Sex steroids are essential for the development of the reproductive tracts, and their function is mediated by activating their receptors. The expression patterns of the receptors have been investigated in previous studies, but the results differ. One of the reasons is a lack of a method to distinguish each region of the reproductive tracts. To distinguish the cranial and caudal Wolffian duct (WD), which contribute to the common efferent duct and epididymal duct, respectively, it is necessary to check the connection with the mesonephric tubules (MTs) that differentiate into the efferent ductules. In this study, we examined the expression patterns of sex steroid receptors in detail to combine the three-dimensional analysis. Serial paraffin sections of the developing murine mesonephros were prepared, and immunohistochemistry for sex steroid receptors, such as estrogen receptor (ESR1), androgen receptor (AR), and progesterone receptor (PR), was performed. Additionally, the sections in which Collagen Type IV was detected were used to reconstruct the MTs and WD. ESR1 was found in the mesenchymal cells around the WD, and the MTs and cranial WD also became positive from the middle period of the development, but the caudal WD was negative for ESR1. AR was first found at the distal end (gonadal side) of the MTs and weakly in the mesenchymal cells. The epithelial expression became strong in the whole length of the MTs and cranial portion of the WD in the middle period of the development. Finally, the caudal part of the WD also showed strong positive just before birth. PR was weakly positive in the MTs and cranial WD, but the distal end of the MTs where the rete cells were adherent was negative for PR. Androgen secreted from the gonad probably acts on the distal end of the MTs to maintain and develop the efferent tubules. ESR1 and PR may also contribute to the development of the efferent duct. Additionally, estrogen treatment in the neonatal male mice induces epididymal inflammation after puberty, but its mechanisms are still unclear. This study found the ESR1 expression in not epithelial cells but mesenchymal cells around the caudal WD. These results suggest that neonatal estrogen treatment probably affects the mesenchymal cells around the epididymal duct, resulting in the inability to suppress the autoimmune response to spermatozoa after puberty." @default.
• W4295346253 created "2022-09-13" @default.
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• W4295346253 date "2022-09-01" @default.
• W4295346253 modified "2023-09-26" @default.
• W4295346253 title "Three-dimensional and immunohistochemical analysis of sex steroid receptors in the developing murine mesonephros" @default.
• W4295346253 doi "https://doi.org/10.1016/j.jri.2022.103718" @default.
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