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- W4295346776 abstract "An appropriate immune response by seminal plasma (SP) is essential for a successful pregnancy and is regarded as a sterile inflammatory response. In contrast, the overactivation of NLRP3 inflammasome is involved in pregnancy complications. We investigated whether NLRP3 inflammasome regulates SP-induced immune response for establishment of pregnancy. The pregnancy continuation rate of wild-type (WT) female mice mated with NLRP3-knockout (KO) male mice was lower, and immune response in their uterus were higher than mated with WT male mice. SP of WT or NLRP3-KO mice was injected into the uterus of mice. The implantation numbers were found to decrease in NLRP3-KO-SP group compared with the WT-SP group. Also, cytokine array analysis showed that most cytokine levels of NLRP3-KO-SP were lower than those of WT-SP. In murine macrophages, treatment with WT-SP increased mRNA expression of inflammatory cytokines and protein expression of macrophage differentiation markers, but not in treatment with NLRP3-KO-SP, suggesting that regulatory capacities of SP differed between WT and NLRP3-KO mice. Moreover, NLRP3 protein was detected in WT-SP, but not in NLRP3-KO-SP. In murine macrophages, treatment with NLRP3 protein increased protein expression of M2 type marker. These results suggest that NLRP3 plays an important role in regulating postcoitus immune response for establishment of pregnancy." @default.
- W4295346776 created "2022-09-13" @default.
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- W4295346776 date "2022-09-01" @default.
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- W4295346776 title "NLRP3 regulates inflammatory response in the uterus by seminal plasma and induces establishment of pregnancy in mice" @default.
- W4295346776 doi "https://doi.org/10.1016/j.jri.2022.103712" @default.
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