FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295347175> ?p ?o ?g. }

• W4295347175 endingPage "e281" @default.
• W4295347175 startingPage "e280" @default.
• W4295347175 abstract "Central MessageDiastolic dysfunction is partially reversed after CABG. Adjunct treatments targeting the reduction of inflammation may further improve diastolic function.See Article page e269. Diastolic dysfunction is partially reversed after CABG. Adjunct treatments targeting the reduction of inflammation may further improve diastolic function. See Article page e269. Despite the performance of anatomically complete revascularization, recovery of myocardial function and regression of symptomatology following coronary artery bypass grafting (CABG) is often incomplete. This impaired recovery is often found to be related to diastolic dysfunction in the setting of significant recovery of systolic function and improvements in ejection fraction. Diastolic dysfunction after CABG associated with poor ventricular compliance as well as elevated left ventricular end-diastolic and pulmonary vascular pressures has been associated with adverse outcomes, including major adverse cardiac events and mortality, and thus remains a challenge to the efficacy of CABG.1Olsen F.J. Lindberg S. Fritz-Hansen T. Modin D. Pedersen S. Iversen A. et al.Prognostic value and interplay between myocardial tissue velocities in patients undergoing coronary artery bypass grafting.Am J Cardiol. 2021; 144: 37-45Abstract Full Text Full Text PDF PubMed Scopus (4) Google Scholar, 2Metkus T.S. Suarez-Pierre A. Crawford T.C. Lawton J.S. Goeddel L. Dodd-O J. et al.Diastolic dysfunction is common and predicts outcome after cardiac surgery.J Cardiothorac Surg. 2018; 13: 67Crossref PubMed Scopus (29) Google Scholar, 3Afilalo J. Flynn A.W. Shimony A. Rudski L.G. Agnihotri A.K. Morin J.F. et al.Incremental value of the preoperative echocardiogram to predict mortality and major morbidity in coronary artery bypass surgery.Circulation. 2013; 127: 356-364Crossref PubMed Scopus (36) Google Scholar, 4Swaminathan M. Nicoara A. Phillips-Bute B.G. Aeschlimann N. Milano C.A. Mackensen G.B. et al.Utility of a simple algorithm to grade diastolic dysfunction and predict outcome after coronary artery bypass graft surgery.Ann Thorac Surg. 2011; 91: 1844-1850Abstract Full Text Full Text PDF PubMed Scopus (78) Google Scholar The etiology of diastolic dysfunction following anatomically complete revascularization remains unclear, but it has been associated with the development of fibrosis and functional impairment of chronically ischemic myocardium.5Heusch G. Myocardial stunning and hibernation revisited.Nat Rev Cardiol. 2021; 18: 522-536https://doi.org/10.1038/s41569-021-00506-7Crossref PubMed Scopus (43) Google Scholar,6Aurigemma G.P. Gaasch W.H. Clinical practice. Diastolic heart failure.N Engl J Med. 2004; 351: 1097-1105Crossref PubMed Scopus (440) Google Scholar The extent of such diastolic dysfunction after reperfusion remained poorly characterized. In the current issue of the Journal, Aggarwal and colleagues7Aggarwal R. Qi S.S. So S.W. Swingen C. Reyes C.P. Rose R. et al.Persistent diastolic dysfunction in chronically ischemic hearts following coronary artery bypass graft.J Thorac Cardiovasc Surg. 2023; 165: e269-e279Abstract Full Text Full Text PDF Scopus (2) Google Scholar provide exploratory mechanistic insight on the pathophysiology of diastolic dysfunction following CABG. Using magnetic resonance imaging in a healthy juvenile porcine myocardial ischemia model, the authors are able to demonstrate persistent diastolic dysfunction 4 weeks after CABG. The authors are able to further demonstrate in this model that CABG only partially reverses inflammation that may have contributed to the conversion of cardiac fibroblasts to collagen-producing myofibroblasts that induce myocardial “stiffening.” Further molecular studies demonstrated that expression of the mitochondrial biogenesis regulator PGC1a was increased and the proinflammatory transcription factor nuclear factor kappa B (NFkB) and other downstream inflammatory mediators such as tumor necrosis factor-alpha were partially decreased to baseline levels after CABG.7Aggarwal R. Qi S.S. So S.W. Swingen C. Reyes C.P. Rose R. et al.Persistent diastolic dysfunction in chronically ischemic hearts following coronary artery bypass graft.J Thorac Cardiovasc Surg. 2023; 165: e269-e279Abstract Full Text Full Text PDF Scopus (2) Google Scholar Given previous evidence that NFkB binds and represses PGC1a expression in cardiomyocytes, the downregulation of NFkB and/or upregulation of PGC1a could decrease inflammation and fibrogenic catalysts and/or enhance myocardial energetics and restore calcium dynamics in such a way as to further improve diastolic relaxation after CABG.8Holley C.T. Long E.K. Butterick T.A. Duffy C.M. Lindsey M.E. Stone L.H. et al.Mitochondrial fusion proteins in revascularized hibernating hearts.J Surg Res. 2015; 195: 29-36https://doi.org/10.1016/j.jss.2014.12.052Abstract Full Text Full Text PDF PubMed Scopus (10) Google Scholar, 9Palomer X. Alvarez-Guardia D. Rodríguez-Calvo R. Coll T. Laguna J.C. Davidson M.M. et al.TNF-alpha reduces PGC-1alpha expression through NF-kappaB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model.Cardiovasc Res. 2009; 81: 703-712Crossref PubMed Scopus (134) Google Scholar, 10Alvarez-Guardia D. Palomer X. Coll T. Davidson M.M. Chan T.O. Feldman A.M. et al.The p65 subunit of NF-kappaB binds to PGC-1alpha, linking inflammation and metabolic disturbances in cardiac cells.Cardiovasc Res. 2010; 87: 449-458Crossref PubMed Scopus (158) Google Scholar This reporting offers an intriguing link between inflammation, mitochondrial dysfunction, and metabolic/calcium flux disturbances that could prove to be ideal secondary treatment avenues to enhance the results of CABG. The current work further suggests mitigation of NFkB-mediated inflammation and/or enhancement of PGC1a expression as specific potential targets for adjuvant molecular interventions in the setting of CABG. Increasing mitochondrial biogenesis, restoring energy homeostasis, and reducing oxidative stress with such an intervention could enhance diastolic recovery following CABG. The extent to which these would need to be preemptive to chronic ischemia, as opposed to adjunctive to CABG, however, is unclear. Were the latter scenario proven to be the case, however, the authors' previous work using epicardial stem cell patches as an adjunct to CABG could represent means to reduce oxidative stress and inflammatory response and thereby inhibit the conversion of fibroblasts into myofibroblasts and improve diastolic dysfunction.11Hocum Stone L.L. Swingen C. Wright C. Qi S.S. Rassette M. McFalls E.O. et al.Recovery of hibernating myocardium using stem cell patch with coronary bypass surgery.J Thorac Cardiovasc Surg. 2021; 162: e3-e16Abstract Full Text Full Text PDF PubMed Scopus (11) Google Scholar PGC1a gene therapy could alternatively be readily delivered therapy via direct myocardial injection of an adenoviral vector during CABG. More broadly, these findings suggest a potential array of molecular and biological interventions as an important adjunct to CABG and other functional cardiomyopathies. Persistent diastolic dysfunction in chronically ischemic hearts following coronary artery bypass graftThe Journal of Thoracic and Cardiovascular SurgeryVol. 165Issue 6PreviewA porcine model was used to study diastolic dysfunction in hibernating myocardium (HM) and recovery with coronary artery bypass surgery (CABG). Full-Text PDF" @default.
• W4295347175 created "2022-09-13" @default.
• W4295347175 creator A5028151019 @default.
• W4295347175 creator A5055250086 @default.
• W4295347175 date "2023-06-01" @default.
• W4295347175 modified "2023-09-25" @default.
• W4295347175 title "Commentary: Myocardial relaxation matters" @default.
• W4295347175 cites W1979384626 @default.
• W4295347175 cites W1986214594 @default.
• W4295347175 cites W2110534414 @default.
• W4295347175 cites W2121904350 @default.
• W4295347175 cites W2126181510 @default.
• W4295347175 cites W2156012869 @default.
• W4295347175 cites W2808146864 @default.
• W4295347175 cites W3000322529 @default.
• W4295347175 cites W3115568340 @default.
• W4295347175 cites W3127581834 @default.
• W4295347175 cites W4293162770 @default.
• W4295347175 doi "https://doi.org/10.1016/j.jtcvs.2022.09.008" @default.
• W4295347175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36207162" @default.
• W4295347175 hasPublicationYear "2023" @default.
• W4295347175 type Work @default.
• W4295347175 citedByCount "0" @default.
• W4295347175 crossrefType "journal-article" @default.
• W4295347175 hasAuthorship W4295347175A5028151019 @default.
• W4295347175 hasAuthorship W4295347175A5055250086 @default.
• W4295347175 hasBestOaLocation W42953471751 @default.
• W4295347175 hasConcept C126322002 @default.
• W4295347175 hasConcept C164705383 @default.
• W4295347175 hasConcept C2776029896 @default.
• W4295347175 hasConcept C71924100 @default.
• W4295347175 hasConceptScore W4295347175C126322002 @default.
• W4295347175 hasConceptScore W4295347175C164705383 @default.
• W4295347175 hasConceptScore W4295347175C2776029896 @default.
• W4295347175 hasConceptScore W4295347175C71924100 @default.
• W4295347175 hasIssue "6" @default.
• W4295347175 hasLocation W42953471751 @default.
• W4295347175 hasLocation W42953471752 @default.
• W4295347175 hasOpenAccess W4295347175 @default.
• W4295347175 hasPrimaryLocation W42953471751 @default.
• W4295347175 hasRelatedWork W1531601525 @default.
• W4295347175 hasRelatedWork W2748952813 @default.
• W4295347175 hasRelatedWork W2758277628 @default.
• W4295347175 hasRelatedWork W2899084033 @default.
• W4295347175 hasRelatedWork W2935909890 @default.
• W4295347175 hasRelatedWork W2948807893 @default.
• W4295347175 hasRelatedWork W3173606202 @default.
• W4295347175 hasRelatedWork W3183948672 @default.
• W4295347175 hasRelatedWork W2778153218 @default.
• W4295347175 hasRelatedWork W3110381201 @default.
• W4295347175 hasVolume "165" @default.
• W4295347175 isParatext "false" @default.
• W4295347175 isRetracted "false" @default.
• W4295347175 workType "article" @default.