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- W4295366557 endingPage "L514" @default.
- W4295366557 startingPage "L503" @default.
- W4295366557 abstract "Laboratory models provide an important tool in helping to understand the cellular and molecular drivers of respiratory disease. Many animal models exist that model the neonatal outcomes of preterm birth. Discoveries at the laboratory bench from examination of both human tissue and tissues from animal models have informed the life-saving technologies and clinical care used today. Yet animal laboratory models of preterm birth have rarely been utilized beyond the neonatal period, despite growing reports of respiratory symptoms and subnormal lung function throughout childhood. Elucidation of the driving factors and physiological explanations underpinning poor outcomes in survivors of preterm birth are crucial to optimize clinical care and identify therapeutic targets. Can existing neonatal models be utilized to study respiratory outcomes beyond infancy? This review answers the question by highlighting the clinical evidence underpinning an active respiratory disease process after preterm birth and exploring the benefits and drawbacks of existing models to conduct research into the long-term respiratory outcomes of preterm birth." @default.
- W4295366557 created "2022-09-13" @default.
- W4295366557 creator A5008739147 @default.
- W4295366557 creator A5035023951 @default.
- W4295366557 creator A5051530018 @default.
- W4295366557 creator A5068367451 @default.
- W4295366557 date "2022-11-01" @default.
- W4295366557 modified "2023-09-25" @default.
- W4295366557 title "Living with lung disease: experimental models to assess the long-term effects of prematurity" @default.
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