FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295410767> ?p ?o ?g. }

• W4295410767 abstract "Immunotherapy might be a promising auxiliary or alternative systemic treatment for early-stage lung adenocarcinomas manifesting as ground-glass nodules (GGNs). This study intended to investigate the PD-L1 expression in these patients, and to explore the non-invasive prediction model of PD-L1 expression based on radiomics.We retrospectively analyzed the PD-L1 expression of patients with postoperative pathological diagnosis of lung adenocarcinomas and with imaging manifestation of GGNs, and divided patients into positive group and negative group according to whether PD-L1 expression ≥1%. Then, CT-based radiomic features were extracted semi-automatically, and feature dimensions were reduced by univariate analysis and LASSO in the randomly selected training cohort (70%). Finally, we used logistic regression algorithm to establish the radiomic models and the clinical-radiomic combined models for PD-L1 expression prediction, and evaluated the prediction efficiency of the models with the receiver operating characteristic (ROC) curves.A total of 839 GGN-like lung adenocarcinoma patients were included, of which 226 (26.9%) showed positive PD-L1 expression. 779 radiomic features were extracted, and 9 of them were found to be highly corelated with PD-L1 expression. The area under the curve (AUC) values of the radiomic models were 0.653 and 0.583 in the training cohort and test cohort respectively. After adding clinically significant and statistically significant clinical features, the efficacy of the combined model was slightly improved, and the AUC values were 0.693 and 0.598 respectively.GGN-like lung adenocarcinoma had a fairly high positive PD-L1 expression rate. Radiomics was a hopeful noninvasive method for predicting PD-L1 expression, with better predictive efficacy in combination with clinical features." @default.
• W4295410767 created "2022-09-13" @default.
• W4295410767 creator A5001580073 @default.
• W4295410767 creator A5011268957 @default.
• W4295410767 creator A5019847788 @default.
• W4295410767 creator A5023152404 @default.
• W4295410767 creator A5041672685 @default.
• W4295410767 creator A5042463866 @default.
• W4295410767 creator A5042947805 @default.
• W4295410767 creator A5042981412 @default.
• W4295410767 creator A5063046834 @default.
• W4295410767 creator A5064149229 @default.
• W4295410767 creator A5068252474 @default.
• W4295410767 creator A5072820962 @default.
• W4295410767 creator A5082742083 @default.
• W4295410767 creator A5089479809 @default.
• W4295410767 date "2022-09-13" @default.
• W4295410767 modified "2023-09-30" @default.
• W4295410767 title "Correlation between PD-L1 expression and radiomic features in early-stage lung adenocarcinomas manifesting as ground-glass nodules" @default.
• W4295410767 cites W1895814318 @default.
• W4295410767 cites W2039400714 @default.
• W4295410767 cites W2071450081 @default.
• W4295410767 cites W2232363786 @default.
• W4295410767 cites W2517065464 @default.
• W4295410767 cites W2527905628 @default.
• W4295410767 cites W2581283430 @default.
• W4295410767 cites W2596415305 @default.
• W4295410767 cites W2745833545 @default.
• W4295410767 cites W2786002326 @default.
• W4295410767 cites W2808178081 @default.
• W4295410767 cites W2898278081 @default.
• W4295410767 cites W2901819812 @default.
• W4295410767 cites W2910245285 @default.
• W4295410767 cites W2913496992 @default.
• W4295410767 cites W2959497269 @default.
• W4295410767 cites W2969900393 @default.
• W4295410767 cites W2983331589 @default.
• W4295410767 cites W2983529249 @default.
• W4295410767 cites W3006010725 @default.
• W4295410767 cites W3010768695 @default.
• W4295410767 cites W3011153338 @default.
• W4295410767 cites W3021010739 @default.
• W4295410767 cites W3021898219 @default.
• W4295410767 cites W3022680805 @default.
• W4295410767 cites W3025674397 @default.
• W4295410767 cites W3033615643 @default.
• W4295410767 cites W3048160945 @default.
• W4295410767 cites W3088889358 @default.
• W4295410767 cites W3089266118 @default.
• W4295410767 cites W3091399767 @default.
• W4295410767 cites W3101368581 @default.
• W4295410767 cites W3106608694 @default.
• W4295410767 cites W3107452708 @default.
• W4295410767 cites W3120081457 @default.
• W4295410767 cites W3124934228 @default.
• W4295410767 cites W3126805615 @default.
• W4295410767 cites W3132841322 @default.
• W4295410767 cites W3134656315 @default.
• W4295410767 cites W3135611798 @default.
• W4295410767 cites W3138937033 @default.
• W4295410767 cites W3139174387 @default.
• W4295410767 cites W3161672899 @default.
• W4295410767 cites W3163414580 @default.
• W4295410767 cites W3170252920 @default.
• W4295410767 cites W3175514092 @default.
• W4295410767 cites W3178223947 @default.
• W4295410767 cites W3183402540 @default.
• W4295410767 cites W3193171465 @default.
• W4295410767 cites W3214284822 @default.
• W4295410767 cites W3217579704 @default.
• W4295410767 cites W4206769087 @default.
• W4295410767 cites W4214498147 @default.
• W4295410767 cites W4221137866 @default.
• W4295410767 cites W4223518016 @default.
• W4295410767 cites W4226382697 @default.
• W4295410767 cites W4229441266 @default.
• W4295410767 cites W4280554654 @default.
• W4295410767 doi "https://doi.org/10.3389/fonc.2022.986579" @default.
• W4295410767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36176405" @default.
• W4295410767 hasPublicationYear "2022" @default.
• W4295410767 type Work @default.
• W4295410767 citedByCount "0" @default.
• W4295410767 crossrefType "journal-article" @default.
• W4295410767 hasAuthorship W4295410767A5001580073 @default.
• W4295410767 hasAuthorship W4295410767A5011268957 @default.
• W4295410767 hasAuthorship W4295410767A5019847788 @default.
• W4295410767 hasAuthorship W4295410767A5023152404 @default.
• W4295410767 hasAuthorship W4295410767A5041672685 @default.
• W4295410767 hasAuthorship W4295410767A5042463866 @default.
• W4295410767 hasAuthorship W4295410767A5042947805 @default.
• W4295410767 hasAuthorship W4295410767A5042981412 @default.
• W4295410767 hasAuthorship W4295410767A5063046834 @default.
• W4295410767 hasAuthorship W4295410767A5064149229 @default.
• W4295410767 hasAuthorship W4295410767A5068252474 @default.
• W4295410767 hasAuthorship W4295410767A5072820962 @default.
• W4295410767 hasAuthorship W4295410767A5082742083 @default.
• W4295410767 hasAuthorship W4295410767A5089479809 @default.
• W4295410767 hasBestOaLocation W42954107671 @default.
• W4295410767 hasConcept C117220453 @default.
• W4295410767 hasConcept C119857082 @default.

• next