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- W4295420150 abstract "Phthalate esters (PAEs) are ubiquitous environmental contaminants, arising growing public concern. Nevertheless, information on the exposure and risks of PAEs in wildlife remains limited. Here, we conducted the first investigation of the occurrences, spatiotemporal trends, and potential risks of twelve metabolites of PAEs (mPAEs) in 74 humpback dolphins from the northern South China Sea during 2005–2020. All twelve mPAEs (∑12mPAEs: 9.6–810.7 ng g−1 wet weight) were detected in the dolphin liver, and seven major mPAEs showed increasing trends during the study period, indicating high PAE contamination in the coastal environment of South China. Monoethylhexyl phthalate accounted for over half of the ∑12mPAE concentrations. The accumulation of mPAEs in the dolphins was neither age-dependent nor sex-specific. Compared to parent PAEs, mPAEs generally induced higher agonistic effects on the dolphin peroxisome proliferator-activated receptor alpha/gamma (PPARA/G) as master regulators of lipid homeostasis. Although short-term in vitro assays revealed no significant activation of dolphin PPARA/G by tissue-relevant doses of mPAEs, long-term in vivo evidence (i.e., correlations between hepatic mPAEs and blubber fatty acids) suggested that chronic exposure to mPAEs might have impacted lipid metabolism in the dolphin. This study highlighted the potential health risks of PAE exposure on marine mammals." @default.
- W4295420150 created "2022-09-14" @default.
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- W4295420150 creator A5058047878 @default.
- W4295420150 date "2023-01-01" @default.
- W4295420150 modified "2023-10-14" @default.
- W4295420150 title "Occurrences and potential lipid-disrupting effects of phthalate metabolites in humpback dolphins from the South China Sea" @default.
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- W4295420150 doi "https://doi.org/10.1016/j.jhazmat.2022.129939" @default.
- W4295420150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36096058" @default.
- W4295420150 hasPublicationYear "2023" @default.
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