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• W4295420680 startingPage "36" @default.
• W4295420680 abstract "To study differences in cytokine expression profiles between women with ongoing pregnancy and those experiencing spontaneous miscarriage, among women who presented with threatened miscarriage before week 16 of gestation.Prospective cohort study.Academic hospital.In this prospective cohort study, 155 pregnant women, comprising normal pregnant women recruited from antenatal clinics (n = 97) and women with threatened miscarriage recruited from an emergency walk-in clinic (n = 58).None.Sixty-five serum cytokines quantified using multiplex immunoassay correlated with miscarriage outcomes.Among women presenting with threatened miscarriage, those who eventually miscarried had significantly lower levels of interleukin (IL)-2, IL-12p70, IL-17A, B-cell-activating factor, B lymphocyte chemoattractant, basic nerve growth factor, interferon-γ, tumor necrosis factor-related apoptosis-inducing ligand, thymic stromal lymphopoietin, and tumor necrosis factor-α and higher levels of vascular endothelial growth factor A, IL-21, and stromal cell-derived factor 1α than those with ongoing pregnancy. Comparisons between normal pregnancies and women with threatened miscarriage who eventually miscarried revealed significant differences across 7 cytokines: B-cell-activating factor; B lymphocyte chemoattractant; basic nerve growth factor; IL-17A; fractalkine/CX3CL1; vascular endothelial growth factor A; and CCL22. Vascular endothelial growth factor A exhibited a negative correlation with the progesterone level (r = -0.270). The cluster of significant cytokines alludes to T cell proliferation, B-cell proliferation, natural killer cell-mediated cytotoxicity, and apoptosis as important pathways that determine pregnancy outcomes. Bioinformatic analysis further revealed alteration of the suppressor of cytokine signaling proteins family of Janus kinase-signal transducer and activator of transcription signaling axis by cytokines as a plausible key molecular mechanism in spontaneous miscarriage.This study demonstrates that the regulated balance between the proinflammatory and anti-inflammatory pathways is crucial to maintaining pregnancy. A better understanding of the cytokines associated with immunomodulatory effects may lead to novel targets for the prediction and treatment of spontaneous miscarriage." @default.
• W4295420680 created "2022-09-14" @default.
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• W4295420680 date "2023-02-01" @default.
• W4295420680 modified "2023-10-01" @default.
• W4295420680 title "Defects in protective cytokine profiles in spontaneous miscarriage in the first trimester" @default.
• W4295420680 cites W1494944113 @default.
• W4295420680 cites W1509926487 @default.
• W4295420680 cites W1510351486 @default.
• W4295420680 cites W1520586419 @default.
• W4295420680 cites W1527815822 @default.
• W4295420680 cites W1691196200 @default.
• W4295420680 cites W1912632961 @default.
• W4295420680 cites W1912661501 @default.
• W4295420680 cites W1968889271 @default.
• W4295420680 cites W1968954564 @default.
• W4295420680 cites W1969672679 @default.
• W4295420680 cites W1973293448 @default.
• W4295420680 cites W1976145906 @default.
• W4295420680 cites W1979277919 @default.
• W4295420680 cites W1980250352 @default.
• W4295420680 cites W1980361506 @default.
• W4295420680 cites W1988337550 @default.
• W4295420680 cites W1994586507 @default.
• W4295420680 cites W2010048541 @default.
• W4295420680 cites W2013833859 @default.
• W4295420680 cites W2014185316 @default.
• W4295420680 cites W2015262412 @default.
• W4295420680 cites W2015821770 @default.
• W4295420680 cites W2019547929 @default.
• W4295420680 cites W2026238172 @default.
• W4295420680 cites W2032172110 @default.
• W4295420680 cites W2036996410 @default.
• W4295420680 cites W2044598005 @default.
• W4295420680 cites W2046468783 @default.
• W4295420680 cites W2051771277 @default.
• W4295420680 cites W2053516651 @default.
• W4295420680 cites W2054358690 @default.
• W4295420680 cites W2057156863 @default.
• W4295420680 cites W2066663558 @default.
• W4295420680 cites W2071680623 @default.
• W4295420680 cites W2081137789 @default.
• W4295420680 cites W2082279156 @default.
• W4295420680 cites W2082700691 @default.
• W4295420680 cites W2088201271 @default.
• W4295420680 cites W2099775615 @default.
• W4295420680 cites W2103183894 @default.
• W4295420680 cites W2106202093 @default.
• W4295420680 cites W2107390412 @default.
• W4295420680 cites W2112031080 @default.
• W4295420680 cites W2116825613 @default.
• W4295420680 cites W2121997180 @default.
• W4295420680 cites W2123309316 @default.
• W4295420680 cites W2126036058 @default.
• W4295420680 cites W2126520365 @default.
• W4295420680 cites W2130051277 @default.
• W4295420680 cites W2130335514 @default.
• W4295420680 cites W2132074882 @default.
• W4295420680 cites W2135782298 @default.
• W4295420680 cites W2136687258 @default.
• W4295420680 cites W2141295972 @default.
• W4295420680 cites W2142427634 @default.
• W4295420680 cites W2149776431 @default.
• W4295420680 cites W2150916684 @default.
• W4295420680 cites W2156958220 @default.
• W4295420680 cites W2158227974 @default.
• W4295420680 cites W2158863190 @default.
• W4295420680 cites W2160938428 @default.
• W4295420680 cites W2161797429 @default.
• W4295420680 cites W2166681530 @default.
• W4295420680 cites W2168417249 @default.
• W4295420680 cites W2169166528 @default.
• W4295420680 cites W2271900218 @default.
• W4295420680 cites W2292868940 @default.
• W4295420680 cites W2592178248 @default.
• W4295420680 cites W2605492484 @default.
• W4295420680 cites W2614898738 @default.
• W4295420680 cites W2718751133 @default.
• W4295420680 cites W2773432877 @default.
• W4295420680 cites W2800458699 @default.
• W4295420680 cites W2810339461 @default.
• W4295420680 cites W2889680493 @default.
• W4295420680 cites W2890344556 @default.
• W4295420680 cites W2977422795 @default.
• W4295420680 cites W2987931162 @default.
• W4295420680 cites W3025098861 @default.
• W4295420680 cites W3033843557 @default.
• W4295420680 cites W3158739196 @default.
• W4295420680 cites W3159531122 @default.
• W4295420680 cites W4232078815 @default.
• W4295420680 cites W2497913308 @default.

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