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- W4295441163 endingPage "e1010412" @default.
- W4295441163 startingPage "e1010412" @default.
- W4295441163 abstract "Homologous recombination (HR) is a double-strand break DNA repair pathway that preserves chromosome structure. To repair damaged DNA, HR uses an intact donor DNA sequence located elsewhere in the genome. After the double-strand break is repaired, DNA sequence information can be transferred between donor and recipient DNA molecules through different mechanisms, including DNA crossovers that form between homologous chromosomes. Regulation of DNA sequence transfer is an important step in effectively completing HR and maintaining genome integrity. For example, mitotic exchange of information between homologous chromosomes can result in loss-of-heterozygosity (LOH), and in higher eukaryotes, the development of cancer. The DNA motor protein Rdh54 is a highly conserved DNA translocase that functions during HR. Several existing phenotypes in rdh54Δ strains suggest that Rdh54 may regulate effective exchange of DNA during HR. In our current study, we used a combination of biochemical and genetic techniques to dissect the role of Rdh54 on the exchange of genetic information during DNA repair. Our data indicate that RDH54 regulates DNA strand exchange by stabilizing Rad51 at an early HR intermediate called the displacement loop (D-loop). Rdh54 acts in opposition to Rad51 removal by the DNA motor protein Rad54. Furthermore, we find that expression of a catalytically inactivate allele of Rdh54, rdh54K318R , favors non-crossover outcomes. From these results, we propose a model for how Rdh54 may kinetically regulate strand exchange during homologous recombination." @default.
- W4295441163 created "2022-09-14" @default.
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- W4295441163 creator A5082895092 @default.
- W4295441163 date "2022-09-13" @default.
- W4295441163 modified "2023-09-28" @default.
- W4295441163 title "Rdh54 stabilizes Rad51 at displacement loop intermediates to regulate genetic exchange between chromosomes" @default.
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- W4295441163 doi "https://doi.org/10.1371/journal.pgen.1010412" @default.
- W4295441163 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36099310" @default.
- W4295441163 hasPublicationYear "2022" @default.
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