Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295445656> ?p ?o ?g. }
- W4295445656 endingPage "33" @default.
- W4295445656 startingPage "26" @default.
- W4295445656 abstract "Pancreatic beta cells are insulin-producing cells that are structurally and functionally polarized in the islets of Langerhans. The organization and position of the Golgi complex play a key role in maintaining a polarized cell state, but the factors and molecular mechanisms determining the Golgi polarization of pancreatic beta cells are still unknown. In the current study, using pancreatic beta cell-specific Atg5 knockout mice, we found that Atg5, an essential gene for autophagy, plays a pivotal role in regulating Golgi integrity and polarization by affecting the expression of genes involved in vesicle transport. Deletion of Atg5 led to endoplasmic reticulum (ER) stress and impaired the distribution of proinsulin and insulin secretion of pancreatic beta cells, which further exacerbates diabetes. These results contribute to a comprehensive understanding of autophagy-mediated Golgi polarization and its regulation of the function of pancreatic beta cells." @default.
- W4295445656 created "2022-09-14" @default.
- W4295445656 creator A5020184709 @default.
- W4295445656 creator A5034551921 @default.
- W4295445656 creator A5043008841 @default.
- W4295445656 creator A5050151730 @default.
- W4295445656 creator A5067223991 @default.
- W4295445656 date "2022-11-01" @default.
- W4295445656 modified "2023-10-17" @default.
- W4295445656 title "The core autophagy protein ATG5 controls the polarity of the Golgi apparatus and insulin secretion of pancreatic beta cells" @default.
- W4295445656 cites W1589179363 @default.
- W4295445656 cites W2006835596 @default.
- W4295445656 cites W2030287946 @default.
- W4295445656 cites W2045567984 @default.
- W4295445656 cites W2047341797 @default.
- W4295445656 cites W2063752629 @default.
- W4295445656 cites W2128537698 @default.
- W4295445656 cites W2130682212 @default.
- W4295445656 cites W2148330792 @default.
- W4295445656 cites W2403802581 @default.
- W4295445656 cites W2493924003 @default.
- W4295445656 cites W2733324404 @default.
- W4295445656 cites W2804838225 @default.
- W4295445656 cites W2907314796 @default.
- W4295445656 cites W2990272651 @default.
- W4295445656 cites W3097236096 @default.
- W4295445656 cites W3121120642 @default.
- W4295445656 cites W3178393591 @default.
- W4295445656 cites W4200026682 @default.
- W4295445656 cites W4220893196 @default.
- W4295445656 cites W4225725639 @default.
- W4295445656 cites W61443419 @default.
- W4295445656 doi "https://doi.org/10.1016/j.bbrc.2022.08.084" @default.
- W4295445656 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36095911" @default.
- W4295445656 hasPublicationYear "2022" @default.
- W4295445656 type Work @default.
- W4295445656 citedByCount "1" @default.
- W4295445656 countsByYear W42954456562022 @default.
- W4295445656 crossrefType "journal-article" @default.
- W4295445656 hasAuthorship W4295445656A5020184709 @default.
- W4295445656 hasAuthorship W4295445656A5034551921 @default.
- W4295445656 hasAuthorship W4295445656A5043008841 @default.
- W4295445656 hasAuthorship W4295445656A5050151730 @default.
- W4295445656 hasAuthorship W4295445656A5067223991 @default.
- W4295445656 hasConcept C119062480 @default.
- W4295445656 hasConcept C126322002 @default.
- W4295445656 hasConcept C134018914 @default.
- W4295445656 hasConcept C158617107 @default.
- W4295445656 hasConcept C165220095 @default.
- W4295445656 hasConcept C185592680 @default.
- W4295445656 hasConcept C190283241 @default.
- W4295445656 hasConcept C203522944 @default.
- W4295445656 hasConcept C2776828364 @default.
- W4295445656 hasConcept C2779306644 @default.
- W4295445656 hasConcept C2781000418 @default.
- W4295445656 hasConcept C49039625 @default.
- W4295445656 hasConcept C55493867 @default.
- W4295445656 hasConcept C6492254 @default.
- W4295445656 hasConcept C71924100 @default.
- W4295445656 hasConcept C86803240 @default.
- W4295445656 hasConcept C90061646 @default.
- W4295445656 hasConcept C95444343 @default.
- W4295445656 hasConceptScore W4295445656C119062480 @default.
- W4295445656 hasConceptScore W4295445656C126322002 @default.
- W4295445656 hasConceptScore W4295445656C134018914 @default.
- W4295445656 hasConceptScore W4295445656C158617107 @default.
- W4295445656 hasConceptScore W4295445656C165220095 @default.
- W4295445656 hasConceptScore W4295445656C185592680 @default.
- W4295445656 hasConceptScore W4295445656C190283241 @default.
- W4295445656 hasConceptScore W4295445656C203522944 @default.
- W4295445656 hasConceptScore W4295445656C2776828364 @default.
- W4295445656 hasConceptScore W4295445656C2779306644 @default.
- W4295445656 hasConceptScore W4295445656C2781000418 @default.
- W4295445656 hasConceptScore W4295445656C49039625 @default.
- W4295445656 hasConceptScore W4295445656C55493867 @default.
- W4295445656 hasConceptScore W4295445656C6492254 @default.
- W4295445656 hasConceptScore W4295445656C71924100 @default.
- W4295445656 hasConceptScore W4295445656C86803240 @default.
- W4295445656 hasConceptScore W4295445656C90061646 @default.
- W4295445656 hasConceptScore W4295445656C95444343 @default.
- W4295445656 hasFunder F4320321001 @default.
- W4295445656 hasFunder F4320321133 @default.
- W4295445656 hasFunder F4320322919 @default.
- W4295445656 hasFunder F4320326139 @default.
- W4295445656 hasLocation W42954456561 @default.
- W4295445656 hasLocation W42954456562 @default.
- W4295445656 hasOpenAccess W4295445656 @default.
- W4295445656 hasPrimaryLocation W42954456561 @default.
- W4295445656 hasRelatedWork W2065635384 @default.
- W4295445656 hasRelatedWork W2075043312 @default.
- W4295445656 hasRelatedWork W2129809791 @default.
- W4295445656 hasRelatedWork W2173352179 @default.
- W4295445656 hasRelatedWork W3033277891 @default.
- W4295445656 hasRelatedWork W3112874773 @default.
- W4295445656 hasRelatedWork W3133088740 @default.
- W4295445656 hasRelatedWork W3191834672 @default.
- W4295445656 hasRelatedWork W3200416367 @default.
- W4295445656 hasRelatedWork W4243182520 @default.