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- W4295459377 startingPage "1033" @default.
- W4295459377 abstract "The Hippo pathway is dysregulated in many different cancers, but point mutations in the pathway are rare. Transcriptional co-activator with PDZ-binding motif (TAZ) and Yes-associated protein (YAP) fusion proteins have emerged in almost all major cancer types and represent the most common genetic mechanism by which the two transcriptional co-activators are activated. Given that the N termini of TAZ or YAP are fused to the C terminus of another transcriptional regulator, the resultant fusion proteins hyperactivate a TEAD transcription factor-based transcriptome. Recent advances show that the C-terminal fusion partners confer oncogenic properties to TAZ/YAP fusion proteins by recruiting epigenetic modifiers that promote a hybrid TEAD-based transcriptome. Elucidating these cooperating epigenetic complexes represents a strategy to identify new therapeutic approaches for a pathway that has been recalcitrant to medical therapy." @default.
- W4295459377 created "2022-09-14" @default.
- W4295459377 creator A5029370540 @default.
- W4295459377 creator A5035007884 @default.
- W4295459377 creator A5041318257 @default.
- W4295459377 creator A5076642000 @default.
- W4295459377 date "2022-12-01" @default.
- W4295459377 modified "2023-09-30" @default.
- W4295459377 title "TAZ/YAP fusion proteins: mechanistic insights and therapeutic opportunities" @default.
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