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• W429548527 abstract "Persistent fetal vasculature (PFV) is a human disease in which the fetal vasculature of the eye fails to regress normally. The fetal, or hyaloid, vasculature nourishes the lens and retina during ocular development, subsequently regressing after formation of the retinal vessels. PFV causes serious congenital pathologies and is responsible for as much as 5% of blindness in the United States.The causes of PFV are poorly understood, however there are a number of animal models in which aspects of the disease are present. One such model results from mutation or elimination of the gene (Cryba1) encoding βA3/A1-crystallin. In this review we focus on the possible mechanisms whereby loss of functional βA3/A1-crystallin might lead to PFV.Cryba1 is abundantly expressed in the lens, but is also expressed in certain other ocular cells, including astrocytes. In animal models lacking βA3/A1-crystallin, astrocyte numbers are increased and they migrate abnormally from the retina to ensheath the persistent hyaloid artery. Evidence is presented that the absence of functional βA3/A1-crystallin causes failure of the normal acidification of endolysosomal compartments in the astrocytes, leading to impairment of certain critical signaling pathways, including mTOR and Notch/STAT3.The findings suggest that impaired endolysosomal signaling in ocular astrocytes can cause PFV disease, by adversely affecting the vascular remodeling processes essential to ocular development, including regression of the fetal vasculature. This article is part of a Special Issue entitled Crystallin Biochemistry in Health and Disease." @default.
• W429548527 created "2016-06-24" @default.
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• W429548527 date "2016-01-01" @default.
• W429548527 modified "2023-10-14" @default.
• W429548527 title "βA3/A1-crystallin and persistent fetal vasculature (PFV) disease of the eye" @default.
• W429548527 cites W1515507925 @default.
• W429548527 cites W1608891270 @default.
• W429548527 cites W1783580437 @default.
• W429548527 cites W1966311581 @default.
• W429548527 cites W1966471287 @default.
• W429548527 cites W1969321137 @default.
• W429548527 cites W1971162717 @default.
• W429548527 cites W1972329350 @default.
• W429548527 cites W1979103878 @default.
• W429548527 cites W1981799488 @default.
• W429548527 cites W1982384802 @default.
• W429548527 cites W1983110676 @default.
• W429548527 cites W1984164703 @default.
• W429548527 cites W1993419164 @default.
• W429548527 cites W1995997868 @default.
• W429548527 cites W1997801717 @default.
• W429548527 cites W2000830616 @default.
• W429548527 cites W2003667792 @default.
• W429548527 cites W2004137618 @default.
• W429548527 cites W2006720649 @default.
• W429548527 cites W2015062592 @default.
• W429548527 cites W2016913573 @default.
• W429548527 cites W2019461187 @default.
• W429548527 cites W2021155213 @default.
• W429548527 cites W2028500434 @default.
• W429548527 cites W2032925076 @default.
• W429548527 cites W2038569321 @default.
• W429548527 cites W2040965438 @default.
• W429548527 cites W2044031095 @default.
• W429548527 cites W2046637432 @default.
• W429548527 cites W2050817855 @default.
• W429548527 cites W2051060938 @default.
• W429548527 cites W2052122676 @default.
• W429548527 cites W2052937933 @default.
• W429548527 cites W2054174655 @default.
• W429548527 cites W2056273367 @default.
• W429548527 cites W2062562477 @default.
• W429548527 cites W2064667094 @default.
• W429548527 cites W2064894017 @default.
• W429548527 cites W2065509478 @default.
• W429548527 cites W2071443355 @default.
• W429548527 cites W2074810887 @default.
• W429548527 cites W2076501672 @default.
• W429548527 cites W2077083517 @default.
• W429548527 cites W2079100663 @default.
• W429548527 cites W2080217080 @default.
• W429548527 cites W2080235746 @default.
• W429548527 cites W2080254956 @default.
• W429548527 cites W2080572190 @default.
• W429548527 cites W2080966061 @default.
• W429548527 cites W2083425643 @default.
• W429548527 cites W2086963517 @default.
• W429548527 cites W2087565211 @default.
• W429548527 cites W2088406510 @default.
• W429548527 cites W2089525975 @default.
• W429548527 cites W2092885934 @default.
• W429548527 cites W2095174527 @default.
• W429548527 cites W2100067283 @default.
• W429548527 cites W2104230245 @default.
• W429548527 cites W2108469833 @default.
• W429548527 cites W2112251383 @default.
• W429548527 cites W2113844457 @default.
• W429548527 cites W2117088742 @default.
• W429548527 cites W2117525838 @default.
• W429548527 cites W2118642448 @default.
• W429548527 cites W2121195075 @default.
• W429548527 cites W2123129865 @default.
• W429548527 cites W2145139438 @default.
• W429548527 cites W2146734921 @default.
• W429548527 cites W2163212976 @default.
• W429548527 cites W2169598826 @default.
• W429548527 cites W261275919 @default.
• W429548527 cites W4251667769 @default.
• W429548527 doi "https://doi.org/10.1016/j.bbagen.2015.05.017" @default.
• W429548527 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4666823" @default.
• W429548527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26022148" @default.
• W429548527 hasPublicationYear "2016" @default.
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