Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295494860> ?p ?o ?g. }
- W4295494860 abstract "IgE mediates allergic responses by coating mast cell or basophil surfaces and inducing degranulation upon binding a specific allergen. IgE can also be spontaneously produced in the absence of foreign allergens; yet the origin, regulation, and functions of such “natural” IgE still remain largely unknown. Here, we find that glucocorticoids enhance the production of IgE in B cells both in vivo and ex vivo without antigenic challenge. Such IgE production is promoted by B cell–intrinsic glucocorticoid receptor signaling that reinforces CD40 signaling and synergizes with the IL-4/STAT6 pathway. In addition, we found that rare B cells in the mesenteric lymph nodes are responsible for the production of glucocorticoid-inducible IgE. Furthermore, locally produced glucocorticoids in the gut may induce natural IgE during perturbations of gut homeostasis, such as dysbiosis. Notably, mice preemptively treated with glucocorticoids were protected from subsequent pathogenic anaphylaxis. Together, our results suggest that glucocorticoids, classically considered to be broadly immunosuppressive, have a selective immunostimulatory role in B cells." @default.
- W4295494860 created "2022-09-14" @default.
- W4295494860 creator A5017585145 @default.
- W4295494860 creator A5019560906 @default.
- W4295494860 creator A5033958039 @default.
- W4295494860 creator A5040597705 @default.
- W4295494860 creator A5049127339 @default.
- W4295494860 creator A5068888495 @default.
- W4295494860 creator A5085581446 @default.
- W4295494860 date "2022-09-13" @default.
- W4295494860 modified "2023-09-30" @default.
- W4295494860 title "Induction of natural IgE by glucocorticoids" @default.
- W4295494860 cites W121740597 @default.
- W4295494860 cites W1525912444 @default.
- W4295494860 cites W1532020552 @default.
- W4295494860 cites W1561015496 @default.
- W4295494860 cites W1898117050 @default.
- W4295494860 cites W1913397935 @default.
- W4295494860 cites W1918912342 @default.
- W4295494860 cites W1962193832 @default.
- W4295494860 cites W1982386486 @default.
- W4295494860 cites W1995436344 @default.
- W4295494860 cites W2005301744 @default.
- W4295494860 cites W2006376420 @default.
- W4295494860 cites W2009342716 @default.
- W4295494860 cites W2011289494 @default.
- W4295494860 cites W2013896740 @default.
- W4295494860 cites W2017152267 @default.
- W4295494860 cites W2028682232 @default.
- W4295494860 cites W2036897871 @default.
- W4295494860 cites W2042450529 @default.
- W4295494860 cites W2044757050 @default.
- W4295494860 cites W2048375178 @default.
- W4295494860 cites W2051984731 @default.
- W4295494860 cites W2056131299 @default.
- W4295494860 cites W2072064533 @default.
- W4295494860 cites W2073530976 @default.
- W4295494860 cites W2075130635 @default.
- W4295494860 cites W2092275678 @default.
- W4295494860 cites W2099589561 @default.
- W4295494860 cites W2108234281 @default.
- W4295494860 cites W2125164691 @default.
- W4295494860 cites W2129761643 @default.
- W4295494860 cites W2133756317 @default.
- W4295494860 cites W2137425057 @default.
- W4295494860 cites W2139358643 @default.
- W4295494860 cites W2140323047 @default.
- W4295494860 cites W2147155644 @default.
- W4295494860 cites W2158789637 @default.
- W4295494860 cites W2159421887 @default.
- W4295494860 cites W2162420224 @default.
- W4295494860 cites W2166368797 @default.
- W4295494860 cites W2170551349 @default.
- W4295494860 cites W2171808845 @default.
- W4295494860 cites W2269204067 @default.
- W4295494860 cites W2273982344 @default.
- W4295494860 cites W2291487710 @default.
- W4295494860 cites W2323326409 @default.
- W4295494860 cites W2336971187 @default.
- W4295494860 cites W2415508338 @default.
- W4295494860 cites W2561180060 @default.
- W4295494860 cites W2565959757 @default.
- W4295494860 cites W2568322374 @default.
- W4295494860 cites W2587941297 @default.
- W4295494860 cites W2604814997 @default.
- W4295494860 cites W2744715029 @default.
- W4295494860 cites W2750416916 @default.
- W4295494860 cites W2785446117 @default.
- W4295494860 cites W2787240390 @default.
- W4295494860 cites W2790266741 @default.
- W4295494860 cites W2833527792 @default.
- W4295494860 cites W2884289363 @default.
- W4295494860 cites W2901823815 @default.
- W4295494860 cites W2903856687 @default.
- W4295494860 cites W2914650668 @default.
- W4295494860 cites W2946146695 @default.
- W4295494860 cites W2954792701 @default.
- W4295494860 cites W2972848523 @default.
- W4295494860 cites W2988261311 @default.
- W4295494860 cites W2998740996 @default.
- W4295494860 cites W3009598951 @default.
- W4295494860 cites W3028239902 @default.
- W4295494860 cites W3036632118 @default.
- W4295494860 cites W3118854353 @default.
- W4295494860 cites W3140141177 @default.
- W4295494860 cites W3199858648 @default.
- W4295494860 cites W4206629829 @default.
- W4295494860 cites W4211171313 @default.
- W4295494860 cites W4220956414 @default.
- W4295494860 doi "https://doi.org/10.1084/jem.20220903" @default.
- W4295494860 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36098746" @default.
- W4295494860 hasPublicationYear "2022" @default.
- W4295494860 type Work @default.
- W4295494860 citedByCount "3" @default.
- W4295494860 countsByYear W42954948602023 @default.
- W4295494860 crossrefType "journal-article" @default.
- W4295494860 hasAuthorship W4295494860A5017585145 @default.
- W4295494860 hasAuthorship W4295494860A5019560906 @default.
- W4295494860 hasAuthorship W4295494860A5033958039 @default.
- W4295494860 hasAuthorship W4295494860A5040597705 @default.