FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295507825> ?p ?o ?g. }

• W4295507825 endingPage "393" @default.
• W4295507825 startingPage "381" @default.
• W4295507825 abstract "Oral squamous cell carcinoma (OSCC) accounts for nearly 90% of oral cavity malignancies. However, despite significant advances in the last four decades, little improvement has been achieved in the overall survival rates for OSCC patients. While gambogic acid (GA) is a potential candidate compound for treating a variety of malignancies, its anti-cancer impact on OSCC has not to be completely investigated. The tumor immune microenvironment (TIME) has been proven to play a crucial role in the prognosis of cancer patients. Although there are few reports on the T cell activation effect of GA, the regulation of GA on the TIME of OSCC has barely been studied yet. In this study, GA was applied to treat OSCC-bearing mice through in situ controlled release. First, GA-loaded mPEG2000-PCL micelles (GA-MIC) were prepared by the thin-film hydration method to improve the aqueous dispersibility of GA. Second, poly(D, l-lactide)-poly(ethylene glycol)-poly(D, l-lactide) (PLEL) was synthesized for thermosensitive hydrogel preparation. Third, GA-MIC was mixed with PLEL to form an injectable therapeutic hydrogel (GA-MIC-GEL). The anti-tumor and TIME regulation effects of GA-MIC-GEL on tumor-bearing mice were further examined. The results showed that the thermosensitive GA-MIC-GEL with sensitive sol-gel transition characteristics could form hydrogel at 37 °C within 24 s, facilitating the local delivery and sustained GA release. Biochemical, hematological, and pathological analysis proved that GA-MIC-GEL has good biological safety. Moreover, GA-MIC-GEL promoted an obvious regression of both primary and distant tumors on the OSCC mouse models. Mechanically, GA-MIC-GEL down-regulated the expression of PD-1, increased the frequency of cytotoxic T cells and reduced the immunosuppressive cellular components, which boosted the anti-tumor immunity of OSCC-bearing mice. The constructed thermosensitive hydrogel for local delivery of GA has provided a safe and effective strategy with great potential for OSCC therapy." @default.
• W4295507825 created "2022-09-14" @default.
• W4295507825 creator A5006266198 @default.
• W4295507825 creator A5008713138 @default.
• W4295507825 creator A5013575245 @default.
• W4295507825 creator A5021649608 @default.
• W4295507825 creator A5023087152 @default.
• W4295507825 creator A5036687874 @default.
• W4295507825 creator A5046800646 @default.
• W4295507825 creator A5072777312 @default.
• W4295507825 date "2022-11-01" @default.
• W4295507825 modified "2023-09-27" @default.
• W4295507825 title "Local delivery of gambogic acid to improve anti-tumor immunity against oral squamous cell carcinoma" @default.
• W4295507825 cites W1990956554 @default.
• W4295507825 cites W1994447535 @default.
• W4295507825 cites W1999234398 @default.
• W4295507825 cites W2009998502 @default.
• W4295507825 cites W2034810796 @default.
• W4295507825 cites W2049191131 @default.
• W4295507825 cites W2098355143 @default.
• W4295507825 cites W2138342044 @default.
• W4295507825 cites W2156353875 @default.
• W4295507825 cites W2239185014 @default.
• W4295507825 cites W2321163035 @default.
• W4295507825 cites W2484603232 @default.
• W4295507825 cites W2524125143 @default.
• W4295507825 cites W2563647161 @default.
• W4295507825 cites W2619691134 @default.
• W4295507825 cites W2767708868 @default.
• W4295507825 cites W2786472249 @default.
• W4295507825 cites W2786987313 @default.
• W4295507825 cites W2791931250 @default.
• W4295507825 cites W2793226176 @default.
• W4295507825 cites W2793992794 @default.
• W4295507825 cites W2883193678 @default.
• W4295507825 cites W2891987281 @default.
• W4295507825 cites W2912211339 @default.
• W4295507825 cites W2919041616 @default.
• W4295507825 cites W2919508314 @default.
• W4295507825 cites W2936659677 @default.
• W4295507825 cites W2950591923 @default.
• W4295507825 cites W2978734201 @default.
• W4295507825 cites W2981477186 @default.
• W4295507825 cites W3004103080 @default.
• W4295507825 cites W3005161065 @default.
• W4295507825 cites W3005964018 @default.
• W4295507825 cites W3011512027 @default.
• W4295507825 cites W3017186824 @default.
• W4295507825 cites W3029236261 @default.
• W4295507825 cites W3032489997 @default.
• W4295507825 cites W3034452919 @default.
• W4295507825 cites W3043750607 @default.
• W4295507825 cites W3047292174 @default.
• W4295507825 cites W3093266015 @default.
• W4295507825 cites W3096337407 @default.
• W4295507825 cites W3104477079 @default.
• W4295507825 cites W3123364893 @default.
• W4295507825 cites W3126048989 @default.
• W4295507825 cites W3129109916 @default.
• W4295507825 cites W3132641642 @default.
• W4295507825 cites W3134294543 @default.
• W4295507825 cites W3134549127 @default.
• W4295507825 cites W3136612579 @default.
• W4295507825 cites W3151350205 @default.
• W4295507825 cites W3182800245 @default.
• W4295507825 cites W3183632913 @default.
• W4295507825 cites W3197521059 @default.
• W4295507825 cites W3205309803 @default.
• W4295507825 doi "https://doi.org/10.1016/j.jconrel.2022.09.010" @default.
• W4295507825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36096364" @default.
• W4295507825 hasPublicationYear "2022" @default.
• W4295507825 type Work @default.
• W4295507825 citedByCount "10" @default.
• W4295507825 countsByYear W42955078252022 @default.
• W4295507825 countsByYear W42955078252023 @default.
• W4295507825 crossrefType "journal-article" @default.
• W4295507825 hasAuthorship W4295507825A5006266198 @default.
• W4295507825 hasAuthorship W4295507825A5008713138 @default.
• W4295507825 hasAuthorship W4295507825A5013575245 @default.
• W4295507825 hasAuthorship W4295507825A5021649608 @default.
• W4295507825 hasAuthorship W4295507825A5023087152 @default.
• W4295507825 hasAuthorship W4295507825A5036687874 @default.
• W4295507825 hasAuthorship W4295507825A5046800646 @default.
• W4295507825 hasAuthorship W4295507825A5072777312 @default.
• W4295507825 hasConcept C121608353 @default.
• W4295507825 hasConcept C126322002 @default.
• W4295507825 hasConcept C142724271 @default.
• W4295507825 hasConcept C1491633281 @default.
• W4295507825 hasConcept C178790620 @default.
• W4295507825 hasConcept C185592680 @default.
• W4295507825 hasConcept C202751555 @default.
• W4295507825 hasConcept C203014093 @default.
• W4295507825 hasConcept C2776107976 @default.
• W4295507825 hasConcept C2777516009 @default.
• W4295507825 hasConcept C2779820397 @default.
• W4295507825 hasConcept C2781360439 @default.
• W4295507825 hasConcept C3019992690 @default.
• W4295507825 hasConcept C502942594 @default.

• next