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- W4295512632 endingPage "43" @default.
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- W4295512632 abstract "Peroxisome proliferator-activated receptors (PPARs) are members of the ligand-dependent nuclear receptor family. PPARs have attracted wide attention as pharmacologic mediators to manage multiple diseases and their underlying signaling targets. They mediate a broad range of specific biological activities and multiple organ toxicity, including cellular differentiation, metabolic syndrome, cancer, atherosclerosis, neurodegeneration, cardiovascular diseases, and inflammation related to their up/downstream signaling pathways. Consequently, several types of selective PPAR ligands, such as fibrates and thiazolidinediones (TZDs), have been approved as their pharmacological agonists. Despite these advances, the use of PPAR agonists is known to cause adverse effects in various systems. Conversely, some naturally occurring PPAR agonists, including polyunsaturated fatty acids and natural endogenous PPAR agonists curcumin and resveratrol, have been introduced as safe agonists as a result of their clinical evidence or preclinical experiments. This review focuses on research on plant-derived active ingredients (natural phytochemicals) as potential safe and promising PPAR agonists. Moreover, it provides a comprehensive review and critique of the role of phytochemicals in PPARs-related diseases and provides an understanding of phytochemical-mediated PPAR-dependent and -independent cascades. The findings of this research will help to define the functions of phytochemicals as potent PPAR pharmacological agonists in underlying disease mechanisms and their related complications." @default.
- W4295512632 created "2022-09-14" @default.
- W4295512632 creator A5004484206 @default.
- W4295512632 creator A5005079115 @default.
- W4295512632 creator A5029199715 @default.
- W4295512632 creator A5041295864 @default.
- W4295512632 creator A5083099452 @default.
- W4295512632 date "2022-08-31" @default.
- W4295512632 modified "2023-09-30" @default.
- W4295512632 title "Impact of Phytochemicals on PPAR Receptors: Implications for Disease Treatments" @default.
- W4295512632 cites W1502914462 @default.
- W4295512632 cites W1533518916 @default.
- W4295512632 cites W1596069616 @default.
- W4295512632 cites W1756594950 @default.
- W4295512632 cites W1807590635 @default.
- W4295512632 cites W1891225011 @default.
- W4295512632 cites W1906282461 @default.
- W4295512632 cites W1924050670 @default.
- W4295512632 cites W1964233751 @default.
- W4295512632 cites W1970651271 @default.
- W4295512632 cites W1971296977 @default.
- W4295512632 cites W1972659108 @default.
- W4295512632 cites W1975493812 @default.
- W4295512632 cites W1978152086 @default.
- W4295512632 cites W1979657807 @default.
- W4295512632 cites W1984274950 @default.
- W4295512632 cites W1987233674 @default.
- W4295512632 cites W1987385741 @default.
- W4295512632 cites W1988821245 @default.
- W4295512632 cites W1988829405 @default.
- W4295512632 cites W1989309894 @default.
- W4295512632 cites W1990886132 @default.
- W4295512632 cites W1994394690 @default.
- W4295512632 cites W1996243900 @default.
- W4295512632 cites W1997820987 @default.
- W4295512632 cites W2002156365 @default.
- W4295512632 cites W2005626949 @default.
- W4295512632 cites W2012593336 @default.
- W4295512632 cites W2013267481 @default.
- W4295512632 cites W2014860670 @default.
- W4295512632 cites W2021706193 @default.
- W4295512632 cites W2024682916 @default.
- W4295512632 cites W2024991664 @default.
- W4295512632 cites W2026928137 @default.
- W4295512632 cites W2032969984 @default.
- W4295512632 cites W2033778707 @default.
- W4295512632 cites W2034015019 @default.
- W4295512632 cites W2034098614 @default.
- W4295512632 cites W2039860526 @default.
- W4295512632 cites W2042262118 @default.
- W4295512632 cites W2042395462 @default.
- W4295512632 cites W2045999552 @default.
- W4295512632 cites W2049321133 @default.
- W4295512632 cites W2053316391 @default.
- W4295512632 cites W2055107232 @default.
- W4295512632 cites W2056198615 @default.
- W4295512632 cites W2057775112 @default.
- W4295512632 cites W2064357983 @default.
- W4295512632 cites W2066143389 @default.
- W4295512632 cites W2074248127 @default.
- W4295512632 cites W2076553098 @default.
- W4295512632 cites W2077273426 @default.
- W4295512632 cites W2078386719 @default.
- W4295512632 cites W2079302588 @default.
- W4295512632 cites W2080915875 @default.
- W4295512632 cites W2085372521 @default.
- W4295512632 cites W2086505785 @default.
- W4295512632 cites W2089052785 @default.
- W4295512632 cites W2089229769 @default.
- W4295512632 cites W2091064562 @default.
- W4295512632 cites W2093352246 @default.
- W4295512632 cites W2096237235 @default.
- W4295512632 cites W2100159014 @default.
- W4295512632 cites W2101044710 @default.
- W4295512632 cites W2105130679 @default.
- W4295512632 cites W2107630715 @default.
- W4295512632 cites W2108369287 @default.
- W4295512632 cites W2110507610 @default.
- W4295512632 cites W2112837646 @default.
- W4295512632 cites W2125091291 @default.
- W4295512632 cites W2127178720 @default.
- W4295512632 cites W2128920875 @default.
- W4295512632 cites W2130070669 @default.
- W4295512632 cites W2131017515 @default.
- W4295512632 cites W2136160261 @default.
- W4295512632 cites W2137404701 @default.
- W4295512632 cites W2138310507 @default.
- W4295512632 cites W2138950515 @default.
- W4295512632 cites W2143062996 @default.
- W4295512632 cites W2144241076 @default.
- W4295512632 cites W2148022015 @default.
- W4295512632 cites W2150815810 @default.
- W4295512632 cites W2156300175 @default.
- W4295512632 cites W2156747994 @default.
- W4295512632 cites W2160770872 @default.
- W4295512632 cites W2161386296 @default.
- W4295512632 cites W2164430911 @default.
- W4295512632 cites W2168114078 @default.