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• W4295512908 abstract "Protease activated receptors (PARs) are among the first receptors shown to transactivate other receptors: noticeably, these interactions are not limited to members of the same family, but involve receptors as diverse as receptor kinases, prostanoid receptors, purinergic receptors and ionic channels among others. In this review, we will focus on the evidence for PAR interactions with members of their own family, as well as with other types of receptors. We will discuss recent evidence as well as what we consider as emerging areas to explore; from the signalling pathways triggered, to the physiological and pathological relevance of these interactions, since this additional level of molecular cross-talk between receptors and signaling pathways is only beginning to be explored and represents a novel mechanism providing diversity to receptor function and play important roles in physiology and disease." @default.
• W4295512908 created "2022-09-14" @default.
• W4295512908 creator A5016427929 @default.
• W4295512908 creator A5054171695 @default.
• W4295512908 creator A5075738540 @default.
• W4295512908 date "2022-09-10" @default.
• W4295512908 modified "2023-10-17" @default.
• W4295512908 title "Diversification of PAR signaling through receptor crosstalk" @default.
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