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- W4295528319 abstract "Abstract Motivation The Hi-C experiments have been extensively used for the studies of mammalian genomic structures. In the last few years, spatiotemporal Hi-C has significantly contributed to the study of genome dynamic reorganization. However, computationally forecasting spatiotemporal Hi-C data still has not been seen in the literature. Results We present HiC4D for addressing the problem of forecasting spatiotemporal Hi-C data. We designed and tested a novel network, which is a combination of residual network and convolutional long short-term memory (ConvLSTM), and named it residual ConvLSTM (ResConvLSTM). We evaluated our new method and compared it with other four methods including three outstanding video-prediction methods from the literature: ConvLSTM, spatiotemporal LSTM (ST-LSTM), and simple video prediction (SimVP), and one self-designed naïve network (NaiveNet) as a baseline. We used four different spatiotemporal Hi-C datasets for the blind test, including two from mouse embryogenesis, one from somatic cell nuclear transfer (SCNT) embryos, and one from human embryogenesis. Our evaluation results indicate that ResConvLSTM almost always outperforms the other four methods on four blind-test datasets in terms of accurately reproducing spatiotemporal Hi-C contact matrices at future time steps. Our benchmarks also indicate that all five methods can successfully recover the boundaries of topologically associating domains (TADs) called on the experimental Hi-C contact matrices. Availability HiC4D is publicly available at http://dna.cs.miami.edu/HiC4D/ ." @default.
- W4295528319 created "2022-09-14" @default.
- W4295528319 creator A5046775442 @default.
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- W4295528319 date "2022-09-13" @default.
- W4295528319 modified "2023-09-30" @default.
- W4295528319 title "HiC4D: Forecasting spatiotemporal Hi-C data with residual ConvLSTM" @default.
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- W4295528319 doi "https://doi.org/10.1101/2022.09.10.507434" @default.
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