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• W4295530651 abstract "Abstract Background Defining and measuring “Health” presents a challenge, partly due to its conceptual pluralism. To measure “Health” as an ability to adapt and self-manage, we developed an approach within the theoretical framework of resources and reserves over the life course, recently proposed in the literature. We aimed to (i) use the conceptual framework developed to identify indicators of deteriorating health reserves, (ii) construct a global health score from these indicators, (iii) evaluate the association between the global health score and subsequent health outcomes and (iv) assess the robustness of our method. Methods We used data from 7,043 individuals born in 1958 in Great Britain included in the National Child Development Study. A global health score was constructed via the sum of three selected indicators of deteriorating health reserves in mid-life: chronic widespread pain (CWP), clinical interview schedule (CIS-r), and allostatic load (AL). A three-category variable was defined: impaired/medium/optimal health. We explored criterion validity by modelling the relationships between the global health score, or each reserve taken separately, and mortality and self-rated health using Cox and logistic regressions respectively. We performed sensitivity analyses to assess the robustness of the method. Results Having an impaired global health score was significantly associated with all-cause premature mortality (HRimpaired= 2.74 [1.86; 4.05]) and an increased risk of later fair/poor/very poor self-rated health (ORimpaired = 7.50 [6.29; 8.95]). The global health score had a greater effect on the self-rated health estimates than each indicator of deteriorating health reserves considered separately (ORAL medium=1.82 [1.59; 2.09]; ORAL high=2.74 [2.37; 3.16]; ORCIS-r= 5.20 [4.45; 6.08]; ORCWP= 2.85 [2.53; 3.21]). Clinical interview schedule and allostatic load were also associated with premature mortality contrary to chronic widespread pain (HRAL medium1.82 [1.27; 2.61]; HRAL high= 3.10 [2.19; 4.40]; HRCIS-r=1.77 [1.22; 2.56]; HRCWP=1.32 [0.98; 1.76]). The multiple sensitivity analyses conducted allowed us to confirm the robustness of our method. Conclusions We proposed a method for measuring a global health score in line with a definition of health based on the concept of reserve. This method may be applied and further developed within the field of social and positive epidemiology." @default.
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• W4295530651 date "2022-09-13" @default.
• W4295530651 modified "2023-10-18" @default.
• W4295530651 title "Toward a conceptual framework of health and its operational definition: an application in the 1958 British birth cohort" @default.
• W4295530651 doi "https://doi.org/10.21203/rs.3.rs-1754002/v1" @default.
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