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- W4295560778 endingPage "1282" @default.
- W4295560778 startingPage "1282" @default.
- W4295560778 abstract "As a bona fide epigenetic marker, DNA methylation has been linked to the differentiation and function of regulatory T (Treg) cells, a subset of CD4 T cells that play an essential role in maintaining immune homeostasis and suppressing autoimmunity and antitumor immune response. DNA methylation undergoes dynamic regulation involving maintenance of preexisting patterns, passive and active demethylation, and de novo methylation. Scattered evidence suggests that these processes control different stages of Treg cell lifespan ranging from lineage induction to cell fate maintenance, suppression of effector T cells and innate immune cells, and transdifferentiation. Despite significant progress, it remains to be fully explored how differential DNA methylation regulates Treg cell fate and immunological function. Here, we review recent progress and discuss the questions and challenges for further understanding the immunological roles and mechanisms of dynamic DNA methylation in controlling Treg cell differentiation and function. We also explore the opportunities that these processes offer to manipulate Treg cell suppressive function for therapeutic purposes by targeting DNA methylation." @default.
- W4295560778 created "2022-09-14" @default.
- W4295560778 creator A5012049637 @default.
- W4295560778 creator A5056386839 @default.
- W4295560778 creator A5058180593 @default.
- W4295560778 creator A5062012597 @default.
- W4295560778 date "2022-09-12" @default.
- W4295560778 modified "2023-10-12" @default.
- W4295560778 title "DNA Methylation in Regulatory T Cell Differentiation and Function: Challenges and Opportunities" @default.
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