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• W4295592016 abstract "Neurodegenerative diseases are caused by the interaction of genetic susceptibility and environmental factors. Although it has been revealed that α-synuclein and tau protein are the key players in neurodegeneration, the process of where they originate and how they make the disease is still unclear. The gut must coexist with various bacteria and inevitably affect the body. Recent studies have revealed that the nervous system and the gut interact, bringing one step closer to the mystery of how neurodegenerative disorders occur. The most common prodromal symptom of Parkinson disease is constipation. Several studies have confirmed that intestinal alpha-synuclein deposition is prominent in patients with Parkinson disease and rapid eye movement sleep behavior disorder, and pathological changes can be transmitted through the vagus nerve. In this sense, there has been a hypothesis to divide the process into two types, brain-first versus body-first, but it is still controversial. It is unclear whether Alzheimer disease is the starting point for pathological changes in the gut like Parkinson disease. However, common pathomechanisms could be applied to both diseases: disrupting the gut and blood-brain barriers, facilitating inflammations, and engaging hormones. Further studies on the gut-brain axis are required to predict and prevent neurodegenerative diseases." @default.
• W4295592016 created "2022-09-14" @default.
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• W4295592016 date "2022-09-15" @default.
• W4295592016 modified "2023-10-14" @default.
• W4295592016 title "Development of neurodegenerative disorders and the role of gut" @default.
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• W4295592016 doi "https://doi.org/10.53991/jgn.2022.00108" @default.
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