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• W4295665611 endingPage "1044" @default.
• W4295665611 startingPage "1019" @default.
• W4295665611 abstract "Similar to other RNA viruses, the emergence of Betacoronavirus relies on cross-species viral transmission, which requires careful health surveillance monitoring of protein-coding information as well as genome-wide analysis. Although the evolutionary jump from natural reservoirs to humans may be mainly traced-back by studying the effect that hotspot mutations have on viral proteins, it is largely unexplored if other impacts might emerge on the structured RNA genome of Betacoronavirus. In this survey, the protein-coding and viral genome architecture were simultaneously studied to uncover novel insights into cross-species horizontal transmission events. We analysed 1,252,952 viral genomes of SARS-CoV, MERS-CoV, and SARS-CoV-2 distributed across the world in bats, intermediate animals, and humans to build a new landscape of changes in the RNA viral genome. Phylogenetic analyses suggest that bat viruses are the most closely related to the time of most recent common ancestor of Betacoronavirus, and missense mutations in viral proteins, mainly in the S protein S1 subunit: SARS-CoV (G > T; A577S); MERS-CoV (C > T; S746R and C > T; N762A); and SARS-CoV-2 (A > G; D614G) appear to have driven viral diversification. We also found that codon sites under positive selection on S protein overlap with non-compensatory mutations that disrupt secondary RNA structures in the RNA genome complement. These findings provide pivotal factors that might be underlying the eventual jumping the species barrier from bats to intermediate hosts. Lastly, we discovered that nearly half of the Betacoronavirus genomes carry highly conserved RNA structures, and more than 90% of these RNA structures show negative selection signals, suggesting essential functions in the biology of Betacoronavirus that have not been investigated to date. Further research is needed on negatively selected RNA structures to scan for emerging functions like the potential of coding virus-derived small RNAs and to develop new candidate antiviral therapeutic strategies." @default.
• W4295665611 created "2022-09-14" @default.
• W4295665611 creator A5024393936 @default.
• W4295665611 creator A5050439276 @default.
• W4295665611 creator A5051563999 @default.
• W4295665611 date "2022-09-14" @default.
• W4295665611 modified "2023-10-17" @default.
• W4295665611 title "RNA structure-altering mutations underlying positive selection on Spike protein reveal novel putative signatures to trace crossing host-species barriers in <i>Betacoronavirus</i>" @default.
• W4295665611 cites W1517000857 @default.
• W4295665611 cites W1605441808 @default.
• W4295665611 cites W1630717967 @default.
• W4295665611 cites W1969042907 @default.
• W4295665611 cites W1977858698 @default.
• W4295665611 cites W1982559408 @default.
• W4295665611 cites W1990059132 @default.
• W4295665611 cites W2012505332 @default.
• W4295665611 cites W2013090907 @default.
• W4295665611 cites W2027655774 @default.
• W4295665611 cites W2028302194 @default.
• W4295665611 cites W2068497781 @default.
• W4295665611 cites W2088302077 @default.
• W4295665611 cites W2093260830 @default.
• W4295665611 cites W2094939159 @default.
• W4295665611 cites W2097977090 @default.
• W4295665611 cites W2106578986 @default.
• W4295665611 cites W2107053896 @default.
• W4295665611 cites W2108512869 @default.
• W4295665611 cites W2108982334 @default.
• W4295665611 cites W2118982822 @default.
• W4295665611 cites W2119111857 @default.
• W4295665611 cites W2127322768 @default.
• W4295665611 cites W2136847298 @default.
• W4295665611 cites W2136872570 @default.
• W4295665611 cites W2137804369 @default.
• W4295665611 cites W2145000136 @default.
• W4295665611 cites W2151409320 @default.
• W4295665611 cites W2157256056 @default.
• W4295665611 cites W2157989648 @default.
• W4295665611 cites W2162496804 @default.
• W4295665611 cites W2167227766 @default.
• W4295665611 cites W2169981472 @default.
• W4295665611 cites W2170747616 @default.
• W4295665611 cites W2170964688 @default.
• W4295665611 cites W2171820897 @default.
• W4295665611 cites W2291379991 @default.
• W4295665611 cites W2528911651 @default.
• W4295665611 cites W2601559170 @default.
• W4295665611 cites W2605343262 @default.
• W4295665611 cites W2750676240 @default.
• W4295665611 cites W2772685483 @default.
• W4295665611 cites W2781938185 @default.
• W4295665611 cites W2789843538 @default.
• W4295665611 cites W2801159594 @default.
• W4295665611 cites W2803708684 @default.
• W4295665611 cites W2807308836 @default.
• W4295665611 cites W2903899730 @default.
• W4295665611 cites W2924539322 @default.
• W4295665611 cites W2949787845 @default.
• W4295665611 cites W2971120609 @default.
• W4295665611 cites W2990427812 @default.
• W4295665611 cites W3001465255 @default.
• W4295665611 cites W3002108456 @default.
• W4295665611 cites W3003217347 @default.
• W4295665611 cites W3003464757 @default.
• W4295665611 cites W3004280078 @default.
• W4295665611 cites W3004620471 @default.
• W4295665611 cites W3008122393 @default.
• W4295665611 cites W3009335299 @default.
• W4295665611 cites W3009912996 @default.
• W4295665611 cites W3011127849 @default.
• W4295665611 cites W3012565918 @default.
• W4295665611 cites W3014233146 @default.
• W4295665611 cites W3015681640 @default.
• W4295665611 cites W3017680297 @default.
• W4295665611 cites W3024057275 @default.
• W4295665611 cites W3031411888 @default.
• W4295665611 cites W3033524464 @default.
• W4295665611 cites W3034330436 @default.
• W4295665611 cites W3037847560 @default.
• W4295665611 cites W3040890586 @default.
• W4295665611 cites W3042535264 @default.
• W4295665611 cites W3046218112 @default.
• W4295665611 cites W3047521009 @default.
• W4295665611 cites W3080513721 @default.
• W4295665611 cites W3084653951 @default.
• W4295665611 cites W3091816512 @default.
• W4295665611 cites W3093336122 @default.
• W4295665611 cites W3093579818 @default.
• W4295665611 cites W3093768302 @default.
• W4295665611 cites W3094367033 @default.
• W4295665611 cites W3094935568 @default.
• W4295665611 cites W3101990450 @default.
• W4295665611 cites W3108643601 @default.
• W4295665611 cites W3113784727 @default.
• W4295665611 cites W3116376362 @default.
• W4295665611 cites W311927316 @default.
• W4295665611 cites W3127145950 @default.
• W4295665611 cites W3134049921 @default.

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