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- W4295678089 abstract "The introduction of highly effective cystic fibrosis transmembrane conductance regulator modulators has resulted in a paradigm shift towards treating underlying cause of cystic fibrosis (CF) rather than the ensuing complications. In this review, we will describe the impact of these small molecules on growth, nutrition, and metabolic status in people with CF (pwCF).Results of clinical trials and real world data demonstrate that these small molecules are having a significant impact of on augmenting body weight, improving nutritional status and reducing gastrointestinal symptom burden. Early treatment can also positively impact on pancreatic endocrine and exocrine function.Nutritional and metabolic management of pwCF needs to change in order to maximize long term health and avoid future complications relating to obesity and increased cardiovascular risk. Longitudinal registry studies will be key to improve our understanding of the longer-term outcome of these new therapies." @default.
- W4295678089 created "2022-09-14" @default.
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- W4295678089 date "2022-09-14" @default.
- W4295678089 modified "2023-10-12" @default.
- W4295678089 title "Nutritional and metabolic management for cystic fibrosis in a post-cystic fibrosis transmembrane conductance modulator era" @default.
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- W4295678089 doi "https://doi.org/10.1097/mcp.0000000000000917" @default.
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