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- W4295679034 abstract "Abstract Background There is growing interest among pediatric institutions for implementing iodine‐131 (I‐131) meta‐iodobenzylguanidine (MIBG) therapy for treating children with high‐risk neuroblastoma. Due to regulations on the medical use of radioactive material (RAM), and the complexity and safety risks associated with the procedure, a multidisciplinary team involving radiation therapy/safety experts is required. Here, we describe methods for implementing pediatric I‐131 MIBG therapy and evaluate our program's robustness via failure modes and effects analysis (FMEA). Methods We formed a multidisciplinary team, involving pediatric oncology, radiation oncology, and radiation safety staff. To evaluate the robustness of the therapy workflow and quantitatively assess potential safety risks, an FMEA was performed. Failure modes were scored (1–10) for their risk of occurrence ( O ), severity ( S ), and being undetected ( D ). Risk priority number (RPN) was calculated from a product of these scores and used to identify high‐risk failure modes. Results A total of 176 failure modes were identified and scored. The majority (94%) of failure modes scored low (RPN <100). The highest risk failure modes were related to training and to drug‐infusion procedures, with the highest S scores being (a) caregivers did not understand radiation safety training ( O = 5.5, S = 7, D = 5.5, RPN = 212); (b) infusion training of staff was inadequate ( O = 5, S = 8, D = 5, RPN = 200); and (c) air in intravenous lines/not monitoring for air in lines ( O = 4.5, S = 8, D = 5, RPN = 180). Conclusion Through use of FMEA methodology, we successfully identified multiple potential points of failure that have allowed us to proactively mitigate risks when implementing a pediatric MIBG program." @default.
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- W4295679034 date "2022-09-14" @default.
- W4295679034 modified "2023-10-17" @default.
- W4295679034 title "Failure modes and effects analysis of pediatric I‐131 MIBG therapy: Program design and potential pitfalls" @default.
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- W4295679034 doi "https://doi.org/10.1002/pbc.29996" @default.
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