FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295691242> ?p ?o ?g. }

• W4295691242 endingPage "109240" @default.
• W4295691242 startingPage "109240" @default.
• W4295691242 abstract "Adjuvants are required to increase the immunogenicity and efficacy of vaccination and enable vaccine dose sparing. Polyinosinic-polycytidylic acid (Poly I:C), a toll-like receptor 3 agonist, is a promising adjuvant candidate that can induce cell-mediated immune responses; however, it remains unlicensed owing to its low stability and toxicity. Calcium phosphate (CaP), a biocompatible and biodegradable nanoparticle, is widely used in biomedicine for stable and targeted drug delivery. In this study, we developed Poly I:C-functionalized CaP (Poly-CaP) and evaluated its vaccine adjuvant efficacy in vitro and in vivo. A half dose of Poly-CaP nanoparticles showed similar efficacy to a full dose of soluble Poly I:C in stimulating bone marrow-derived dendritic cells and macrophages to secrete proinflammatory cytokines and express their activation markers. Immunization with a half dose of inactivated influenza vaccine in the presence of Poly I:C or Poly-CaP adjuvants induced sufficient antigen-specific humoral responses after boost immunization. Immunization with Poly I:C, CaP, or Poly-CaP-adjuvanted with a half dose of influenza vaccine showed comparable protective efficacy against lethal virus infection, with lower weight loss and virus titer than a full dose of influenza vaccine. The Poly-CaP adjuvant was effective in stimulating antigen-specific CD4+ T cell proliferation in the lungs. Collectively, our results showed that the Poly-CaP adjuvant enhanced antigen-specific cell-mediated immunity and humoral immune responses with vaccine dose-sparing effects, suggesting its potential as a novel vaccine adjuvant candidate." @default.
• W4295691242 created "2022-09-14" @default.
• W4295691242 creator A5002079683 @default.
• W4295691242 creator A5009331275 @default.
• W4295691242 creator A5013600325 @default.
• W4295691242 creator A5034625428 @default.
• W4295691242 creator A5048938308 @default.
• W4295691242 creator A5079365762 @default.
• W4295691242 date "2022-11-01" @default.
• W4295691242 modified "2023-09-25" @default.
• W4295691242 title "Protective and vaccine dose-sparing efficacy of Poly I:C-functionalized calcium phosphate nanoparticle adjuvants in inactivated influenza vaccination" @default.
• W4295691242 cites W1514748884 @default.
• W4295691242 cites W1534496719 @default.
• W4295691242 cites W1586165122 @default.
• W4295691242 cites W1977455495 @default.
• W4295691242 cites W1989148485 @default.
• W4295691242 cites W1992094315 @default.
• W4295691242 cites W1998975401 @default.
• W4295691242 cites W2003055084 @default.
• W4295691242 cites W2003493943 @default.
• W4295691242 cites W2009603559 @default.
• W4295691242 cites W2014730611 @default.
• W4295691242 cites W2030362470 @default.
• W4295691242 cites W2035568993 @default.
• W4295691242 cites W2039925180 @default.
• W4295691242 cites W2041711928 @default.
• W4295691242 cites W2044399538 @default.
• W4295691242 cites W2061600879 @default.
• W4295691242 cites W2065662524 @default.
• W4295691242 cites W2070841458 @default.
• W4295691242 cites W2078830568 @default.
• W4295691242 cites W2090640877 @default.
• W4295691242 cites W2090928701 @default.
• W4295691242 cites W2105091637 @default.
• W4295691242 cites W2120404094 @default.
• W4295691242 cites W2123909340 @default.
• W4295691242 cites W2131330781 @default.
• W4295691242 cites W2139186763 @default.
• W4295691242 cites W2144887013 @default.
• W4295691242 cites W2153164882 @default.
• W4295691242 cites W2153643495 @default.
• W4295691242 cites W2154434805 @default.
• W4295691242 cites W2156313733 @default.
• W4295691242 cites W2158766613 @default.
• W4295691242 cites W2256756668 @default.
• W4295691242 cites W2586083693 @default.
• W4295691242 cites W2589232255 @default.
• W4295691242 cites W2734776573 @default.
• W4295691242 cites W2763252130 @default.
• W4295691242 cites W2765549458 @default.
• W4295691242 cites W2767157048 @default.
• W4295691242 cites W2772049918 @default.
• W4295691242 cites W2912043101 @default.
• W4295691242 cites W2912608580 @default.
• W4295691242 cites W2914038221 @default.
• W4295691242 cites W2937384770 @default.
• W4295691242 cites W2941800282 @default.
• W4295691242 cites W2954218492 @default.
• W4295691242 cites W2995764816 @default.
• W4295691242 cites W3014716479 @default.
• W4295691242 cites W3023255929 @default.
• W4295691242 cites W3046066248 @default.
• W4295691242 cites W3087341228 @default.
• W4295691242 cites W3091948925 @default.
• W4295691242 cites W3113774549 @default.
• W4295691242 cites W3120661281 @default.
• W4295691242 cites W3123442553 @default.
• W4295691242 cites W3126367477 @default.
• W4295691242 cites W3200646269 @default.
• W4295691242 cites W4200562037 @default.
• W4295691242 cites W4377261262 @default.
• W4295691242 cites W2792976722 @default.
• W4295691242 doi "https://doi.org/10.1016/j.intimp.2022.109240" @default.
• W4295691242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36115278" @default.
• W4295691242 hasPublicationYear "2022" @default.
• W4295691242 type Work @default.
• W4295691242 citedByCount "0" @default.
• W4295691242 crossrefType "journal-article" @default.
• W4295691242 hasAuthorship W4295691242A5002079683 @default.
• W4295691242 hasAuthorship W4295691242A5009331275 @default.
• W4295691242 hasAuthorship W4295691242A5013600325 @default.
• W4295691242 hasAuthorship W4295691242A5034625428 @default.
• W4295691242 hasAuthorship W4295691242A5048938308 @default.
• W4295691242 hasAuthorship W4295691242A5079365762 @default.
• W4295691242 hasConcept C147483822 @default.
• W4295691242 hasConcept C203014093 @default.
• W4295691242 hasConcept C22070199 @default.
• W4295691242 hasConcept C2777863537 @default.
• W4295691242 hasConcept C2780689484 @default.
• W4295691242 hasConcept C2780801004 @default.
• W4295691242 hasConcept C2780868878 @default.
• W4295691242 hasConcept C71924100 @default.
• W4295691242 hasConcept C8891405 @default.
• W4295691242 hasConceptScore W4295691242C147483822 @default.
• W4295691242 hasConceptScore W4295691242C203014093 @default.
• W4295691242 hasConceptScore W4295691242C22070199 @default.
• W4295691242 hasConceptScore W4295691242C2777863537 @default.
• W4295691242 hasConceptScore W4295691242C2780689484 @default.

• next