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- W4295693558 abstract "Abstract Objective: Our previous results have demonstrated that spinal cord injury(SCI) can induce hippocampus injury and depression in rodents. Ginsenoside Rg1 is efficient to prevent neurodegenerative disorders. This study aim to investigate the effects of ginsenoside Rg1 in hippocampus after SCI. Method: We used a rat compression SCI model. Western blotting and morphological assays were used to investigate protective effects of Ginsenoside Rg1 in the hippocampus. Results: The results demonstrated that BDNF/ERK signaling is altered in the hippocampus at 5 weeks after SCI. SCI attenuates neurogenesis and enhances the expression of cleaved caspase-3 in the hippocampus. Moreover, ginsenoside Rg1 can attenuate the expression of cleaved caspase-3 and improve the number of neurogenesis and the expression of BDNF/ERK signaling in the rat hippocampus. The results thus suggest that SCI affects BDNF/ERK signaling, and ginsenoside Rg1 can attenuate the damage of hippocampus after SCI. Conclusion: We speculate that the protective effects of ginsenoside Rg1 in hippocampal pathophysiological after SCI may involve BDNF/ERK signaling. Ginsenoside Rg1 may serve as a therapeutic pharmaceutical product in the futurewhen seeking to counter SCI-induced hippocampal damage." @default.
- W4295693558 created "2022-09-14" @default.
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- W4295693558 date "2022-09-14" @default.
- W4295693558 modified "2023-09-26" @default.
- W4295693558 title "Ginsenoside Rg1 attenuates neurogenesis disorder and neuronal apoptosis in the rat hippocampus after spinal cord injury may involve BDNF/ERK signaling" @default.
- W4295693558 doi "https://doi.org/10.21203/rs.3.rs-1713893/v2" @default.
- W4295693558 hasPublicationYear "2022" @default.
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