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• W4295693780 startingPage "211" @default.
• W4295693780 abstract "Abstract Since its development in 2005, incobotulinum toxin A (INCO) has become one of the most widely used neurotoxins worldwide for aesthetic and therapeutic indications. It was initially designed as a formulation free of complex proteins for reduced immunogenicity with an equal action and strength profile to the original and widespread onabotulinum toxin A (ONA). Multiple trials have demonstrated equivalent efficacy. Several studies have suggested a slight decrease in the time of visible treatment onset with INCO and a subsequent lack of difference in duration of effects when compared with ONA. Particularly appreciable with therapeutic doses, utilization of INCO led to significant cost savings over ONA or abobotulinum toxin A. Karschney et al. found that for the treatment of cervical dystonia and chronic migraine the cost to patients was reduced by 32.2% compared to ONA. Additionally, the ONA formulation allows for long‐term storage at room temperature along with an increased stability time once reconstituted. Limitations of INCO include a similar side effect profile to other neurotoxin formulations, more likely at therapeutic dosing. Indications approved by the Federal Drug Administration in the United States and other regulatory agencies are currently more limited than those of ONA, though this may be in direct relation to the length of time on the market. INCO has overall been demonstrated to be a safe, efficacious alternative to other common neurotoxin formulations." @default.
• W4295693780 created "2022-09-14" @default.
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• W4295693780 date "2022-08-01" @default.
• W4295693780 modified "2023-09-26" @default.
• W4295693780 title "Incobotulinum toxin A: A shelf‐stable, low‐molecular‐weight formulation" @default.
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• W4295693780 doi "https://doi.org/10.1002/der2.157" @default.
• W4295693780 hasPublicationYear "2022" @default.
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