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- W4295693818 abstract "Cholesterol is an essential component of animal cells. Different regulatory mechanisms converge to maintain adequate levels of this lipid because both its deficiency and excess are unfavorable. Low cell cholesterol content promotes its synthesis and uptake from circulating lipoproteins. In contrast, its excess induces the efflux to high-density lipoproteins (HDL) and their transport to the liver for excretion, a process known as reverse cholesterol transport. Different studies suggest that an abnormal HDL metabolism hinders female fertility. HDL are the only lipoproteins detected in substantial amounts in follicular fluid (FF), and their size and composition correlate with embryo quality. Oocytes obtain cholesterol from cumulus cells via gap junctions because they cannot synthesize cholesterol de novo and lack HDL receptors. Recent evidence has supported the possibility that FF HDL play a major role in taking up excess unesterified cholesterol (UC) from the oocyte. Indeed, genetically modified mouse models with disruptions in reverse cholesterol transport, some of which show excessive circulating UC levels, exhibit female infertility. Cholesterol accumulation can affect the egg´s viability, as reported in other cell types, and activate the plasma membrane structure and activity of membrane proteins. Indeed, in mice deficient for the HDL receptor Scavenger Class B Type I (SR-B1), excess circulating HDL cholesterol and UC accumulation in oocytes impairs meiosis arrest and hinders the developmental capacity of the egg. In other cells, the addition of cholesterol activates calcium channels and dysregulates cell death/survival signaling pathways, suggesting that these mechanisms may link altered HDL cholesterol metabolism and infertility. Although cholesterol, and lipids in general, are usually not evaluated in infertile patients, one study reported high circulating UC levels in women showing longer time to pregnancy as an outcome of fertility. Based on the evidence described above, we propose the existence of a well-regulated and largely unexplored system of cholesterol homeostasis controlling traffic between FF HDL and oocytes, with significant implications for female fertility." @default.
- W4295693818 created "2022-09-14" @default.
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- W4295693818 date "2022-09-14" @default.
- W4295693818 modified "2023-10-13" @default.
- W4295693818 title "Implications of High-Density Cholesterol Metabolism for Oocyte Biology and Female Fertility" @default.
- W4295693818 cites W120487505 @default.
- W4295693818 cites W1504218378 @default.
- W4295693818 cites W1518983382 @default.
- W4295693818 cites W1626021976 @default.
- W4295693818 cites W18060272 @default.
- W4295693818 cites W1860908381 @default.
- W4295693818 cites W1921017818 @default.
- W4295693818 cites W1963832918 @default.
- W4295693818 cites W1964827297 @default.
- W4295693818 cites W1965751853 @default.
- W4295693818 cites W1965754770 @default.
- W4295693818 cites W1967090815 @default.
- W4295693818 cites W1971842547 @default.
- W4295693818 cites W1972483153 @default.
- W4295693818 cites W1976672898 @default.
- W4295693818 cites W1977029333 @default.
- W4295693818 cites W1977799249 @default.
- W4295693818 cites W1980064899 @default.
- W4295693818 cites W1981003642 @default.
- W4295693818 cites W1983611278 @default.
- W4295693818 cites W1985170971 @default.
- W4295693818 cites W1986386691 @default.
- W4295693818 cites W1988426085 @default.
- W4295693818 cites W1988838278 @default.
- W4295693818 cites W1988904536 @default.
- W4295693818 cites W1996060236 @default.
- W4295693818 cites W1996180854 @default.
- W4295693818 cites W1997307574 @default.
- W4295693818 cites W1997396883 @default.
- W4295693818 cites W2003362774 @default.
- W4295693818 cites W2008655428 @default.
- W4295693818 cites W2013907285 @default.
- W4295693818 cites W2015119995 @default.
- W4295693818 cites W2017760793 @default.
- W4295693818 cites W2018490812 @default.
- W4295693818 cites W2018885343 @default.
- W4295693818 cites W2028545985 @default.
- W4295693818 cites W2039486449 @default.
- W4295693818 cites W2039780593 @default.
- W4295693818 cites W2041336253 @default.
- W4295693818 cites W2043013787 @default.
- W4295693818 cites W2047471212 @default.
- W4295693818 cites W2053335209 @default.
- W4295693818 cites W2063327106 @default.
- W4295693818 cites W2070053386 @default.
- W4295693818 cites W2070877441 @default.
- W4295693818 cites W2072433515 @default.
- W4295693818 cites W2081213583 @default.
- W4295693818 cites W2082032805 @default.
- W4295693818 cites W2084385092 @default.
- W4295693818 cites W2086808671 @default.
- W4295693818 cites W2087250632 @default.
- W4295693818 cites W2104978128 @default.
- W4295693818 cites W2108626995 @default.
- W4295693818 cites W2110543624 @default.
- W4295693818 cites W2111528756 @default.
- W4295693818 cites W2121139264 @default.
- W4295693818 cites W2122684581 @default.
- W4295693818 cites W2123277537 @default.
- W4295693818 cites W2123623722 @default.
- W4295693818 cites W2124760389 @default.
- W4295693818 cites W2128986402 @default.
- W4295693818 cites W2130897208 @default.
- W4295693818 cites W2133364371 @default.
- W4295693818 cites W2135268203 @default.
- W4295693818 cites W2137263717 @default.
- W4295693818 cites W2141191381 @default.
- W4295693818 cites W2141755139 @default.
- W4295693818 cites W2145532583 @default.
- W4295693818 cites W2146656685 @default.
- W4295693818 cites W2149936416 @default.
- W4295693818 cites W2151049620 @default.
- W4295693818 cites W2152005594 @default.
- W4295693818 cites W2152919673 @default.
- W4295693818 cites W2153317802 @default.
- W4295693818 cites W2155496880 @default.
- W4295693818 cites W2155839284 @default.
- W4295693818 cites W2157736704 @default.
- W4295693818 cites W2158370326 @default.
- W4295693818 cites W2159669930 @default.
- W4295693818 cites W2165288563 @default.
- W4295693818 cites W2166054649 @default.
- W4295693818 cites W2166606079 @default.
- W4295693818 cites W2166861819 @default.
- W4295693818 cites W2168761551 @default.
- W4295693818 cites W2277640232 @default.
- W4295693818 cites W2404241423 @default.
- W4295693818 cites W2416197308 @default.
- W4295693818 cites W2557880234 @default.
- W4295693818 cites W2560393860 @default.