FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295700827> ?p ?o ?g. }

• W4295700827 abstract "Clinical and animal studies demonstrated that neuroinflammation from anesthesia (sevoflurane) is the main contributor to cause perioperative neurocognitive disorders (PND). Recently, it was reported that microglia respond to hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, which was the target of sevoflurane. Whether HCN channels are involved in the induction of neuroinflammation after sevoflurane exposure is still unclear.Sevoflurane exposure had increased cognitive dysfunction and anxiety-like behaviors in rats. Rats inhaled with sevoflurane had activated microglia and increased neuroinflammation (IL-1β, IL-6, and TNF-α) in the hippocampus. RNA sequencing identified 132 DEGs (86 up-regulated and 46 down-regulated DEGs [differentially expressed genes]) in the hippocampus of PND rats. RNA-sequencing also uncovered that sevoflurane exposure down-regulates HCN2 expression. Pathway and process enrichment analysis suggests DEGs are mainly enriched in regulation of system process, positive regulation of glutamate secretion, secretion, regulation of synaptic transmission, regulation of nervous system process, behavior, negative regulation of sodium ion transport, and learning or memory. We validated that sevoflurane exposure can down-regulate the levels of PEX5R/Trip8b (an interaction partner and auxiliary subunit of HCN channels) and HCN1-4 channels in the hippocampus of PND rats. We used immunofluorescence staining to identify that HCN2 co-labels with neurons (Neun), astrocytes (GFAP), and microglia (iba1). We observed that the co-labeling of HCN2 with neurons or microglia decreased in the hippocampus and cortex after sevoflurane exposure. Blocking HCN2 by ZD7288 treatment further activated microglia and aggravated sevoflurane exposure-induced anxiety-like behavior, cognitive impairment, and neuroinflammation.We concluded that sevoflurane exposure can induce an increased level of neuroinflammation, microglial activation, cognitive dysfunction, and anxiety-like behaviors in rats. HCN2 channel, as the target of sevoflurane action, mediates this process. HCN2 might be a target for the treatment and prevention of sevoflurane-induced PND." @default.
• W4295700827 created "2022-09-14" @default.
• W4295700827 creator A5009019549 @default.
• W4295700827 creator A5024024325 @default.
• W4295700827 creator A5024224542 @default.
• W4295700827 creator A5037621362 @default.
• W4295700827 creator A5051717382 @default.
• W4295700827 creator A5061628223 @default.
• W4295700827 creator A5080744951 @default.
• W4295700827 creator A5089903476 @default.
• W4295700827 date "2022-09-14" @default.
• W4295700827 modified "2023-10-15" @default.
• W4295700827 title "PEX5R/Trip8b-HCN2 channel regulating neuroinflammation involved in perioperative neurocognitive disorders" @default.
• W4295700827 cites W1145655808 @default.
• W4295700827 cites W1841780104 @default.
• W4295700827 cites W1969373823 @default.
• W4295700827 cites W1970694369 @default.
• W4295700827 cites W1981953596 @default.
• W4295700827 cites W2020742186 @default.
• W4295700827 cites W2044699444 @default.
• W4295700827 cites W2077401778 @default.
• W4295700827 cites W2135735522 @default.
• W4295700827 cites W2162055755 @default.
• W4295700827 cites W2163485494 @default.
• W4295700827 cites W2410955968 @default.
• W4295700827 cites W2416714688 @default.
• W4295700827 cites W2464240089 @default.
• W4295700827 cites W2465471481 @default.
• W4295700827 cites W2557833574 @default.
• W4295700827 cites W2558534012 @default.
• W4295700827 cites W2591439580 @default.
• W4295700827 cites W2604235446 @default.
• W4295700827 cites W2769241563 @default.
• W4295700827 cites W2770121287 @default.
• W4295700827 cites W2800724199 @default.
• W4295700827 cites W2802805418 @default.
• W4295700827 cites W2808555578 @default.
• W4295700827 cites W2900569176 @default.
• W4295700827 cites W2911127509 @default.
• W4295700827 cites W2921188780 @default.
• W4295700827 cites W2928665623 @default.
• W4295700827 cites W2971897041 @default.
• W4295700827 cites W2993145014 @default.
• W4295700827 cites W3000018611 @default.
• W4295700827 cites W3015173695 @default.
• W4295700827 cites W3023674756 @default.
• W4295700827 cites W3043888651 @default.
• W4295700827 cites W3046380479 @default.
• W4295700827 cites W3050737291 @default.
• W4295700827 cites W3109894328 @default.
• W4295700827 cites W3121180761 @default.
• W4295700827 cites W3122021375 @default.
• W4295700827 cites W3126178289 @default.
• W4295700827 cites W3126390049 @default.
• W4295700827 cites W3127573614 @default.
• W4295700827 cites W3186576209 @default.
• W4295700827 cites W3192254066 @default.
• W4295700827 cites W3199228578 @default.
• W4295700827 cites W3199404628 @default.
• W4295700827 cites W3206369863 @default.
• W4295700827 cites W346748628 @default.
• W4295700827 cites W4281394624 @default.
• W4295700827 cites W4281927071 @default.
• W4295700827 doi "https://doi.org/10.1186/s13578-022-00892-6" @default.
• W4295700827 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36104739" @default.
• W4295700827 hasPublicationYear "2022" @default.
• W4295700827 type Work @default.
• W4295700827 citedByCount "3" @default.
• W4295700827 countsByYear W42957008272023 @default.
• W4295700827 crossrefType "journal-article" @default.
• W4295700827 hasAuthorship W4295700827A5009019549 @default.
• W4295700827 hasAuthorship W4295700827A5024024325 @default.
• W4295700827 hasAuthorship W4295700827A5024224542 @default.
• W4295700827 hasAuthorship W4295700827A5037621362 @default.
• W4295700827 hasAuthorship W4295700827A5051717382 @default.
• W4295700827 hasAuthorship W4295700827A5061628223 @default.
• W4295700827 hasAuthorship W4295700827A5080744951 @default.
• W4295700827 hasAuthorship W4295700827A5089903476 @default.
• W4295700827 hasBestOaLocation W42957008271 @default.
• W4295700827 hasConcept C126322002 @default.
• W4295700827 hasConcept C169760540 @default.
• W4295700827 hasConcept C2776914184 @default.
• W4295700827 hasConcept C2779830541 @default.
• W4295700827 hasConcept C2781161787 @default.
• W4295700827 hasConcept C2781453256 @default.
• W4295700827 hasConcept C71924100 @default.
• W4295700827 hasConcept C86803240 @default.
• W4295700827 hasConcept C87753298 @default.
• W4295700827 hasConcept C98274493 @default.
• W4295700827 hasConceptScore W4295700827C126322002 @default.
• W4295700827 hasConceptScore W4295700827C169760540 @default.
• W4295700827 hasConceptScore W4295700827C2776914184 @default.
• W4295700827 hasConceptScore W4295700827C2779830541 @default.
• W4295700827 hasConceptScore W4295700827C2781161787 @default.
• W4295700827 hasConceptScore W4295700827C2781453256 @default.
• W4295700827 hasConceptScore W4295700827C71924100 @default.
• W4295700827 hasConceptScore W4295700827C86803240 @default.
• W4295700827 hasConceptScore W4295700827C87753298 @default.
• W4295700827 hasConceptScore W4295700827C98274493 @default.
• W4295700827 hasFunder F4320321001 @default.

• next