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• W4295709191 startingPage "104173" @default.
• W4295709191 abstract "BackgroundCognitive impairment is a common manifestation of multiple sclerosis (MS).ObjectiveTo assess by systematic review and meta-analysis available evidence regarding the impact of nabiximols oromucosal spray on cognition in patients with MS.MethodsA systematic literature search of clinical studies (all types, any comparator) that measured cognitive function in patients with MS spasticity treated with nabiximols. Meta-analysis for cognitive endpoints was not possible due to heterogenous measurement instruments and outcomes. Meta-analysis was performed for adverse events (AEs) of special interest (cognition disorders) reported in randomized controlled trials (RCTs) of nabiximols versus placebo in patients with MS (with or without spasticity). Certainty of evidence and risk of bias were assessed.ResultsSeven clinical studies (three RCTs) directly assessing cognitive function were included in the qualitative analysis. There was no consistent evidence to suggest that nabiximols causes cognitive impairment as assessed by a range of specific psychometric instruments across cognitive domains. Thirteen double-blind, placebo-controlled RCTs (nabiximols, n = 964; placebo, n = 904) were included in the meta-analysis of cognitive AEs. Most cognitive AEs (30 of 32 events, 93.8%) reported with nabiximols in MS patients occurred with not in-label use, i.e., dosage >12 sprays per day and/or not administered primarily for treatment of spasticity.ConclusionsWithin the limitations of the review, we can conclude that no detrimental effects of nabiximols on cognitive function were observed in patients with MS spasticity during up to 12 months follow-up and that cognitive AEs were rare and occurred only when nabiximols was not used according to its approved label." @default.
• W4295709191 created "2022-09-14" @default.
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• W4295709191 date "2022-12-01" @default.
• W4295709191 modified "2023-10-17" @default.
• W4295709191 title "Effects of SativexⓇ on cognitive function in patients with multiple sclerosis: A systematic review and meta-analysis" @default.
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• W4295709191 doi "https://doi.org/10.1016/j.msard.2022.104173" @default.
• W4295709191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36174323" @default.
• W4295709191 hasPublicationYear "2022" @default.
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