FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295736541> ?p ?o ?g. }

• W4295736541 endingPage "288" @default.
• W4295736541 startingPage "280" @default.
• W4295736541 abstract "Immune dysregulation has been linked to both psychiatric illness and pregnancy morbidity, including perinatal depression, but little is known about the immune phenotype of perinatal anxiety. Here, we sought to identify the unique immune profile of antenatal anxiety. Pregnant women (n = 107) were followed prospectively at 2nd and 3rd trimesters (T2, T3) and 6 weeks postpartum (PP6). Each visit included a blood draw and psychological evaluation, with clinical anxiety assessed using the Spielberg State-Trait Anxiety Scale. We enrolled both healthy controls and participants with anxiety alone; those with comorbid depression were excluded. Multiplex cytokine assays and flow cytometry were used to examine the association of anxiety symptoms with secreted immune markers and PBMC-derived immune cells. K cluster means revealed three clusters of anxiety symptomatology; due to low numbers in the highest severity anxiety group, these were collapsed into two groups: Non-Anxiety and Anxiety. Principal components analysis revealed two distinct clusters of cytokine secretion including one cluster that consisted of many innate immune cytokines and differed between groups. Compared to women in the Non-Anxiety group, women in the Anxiety group had lower levels of cytokine expression during pregnancy and an increase in levels into the postpartum, whereas Non-Anxiety women experienced a time-dependent decline. Immune cell populations also differed between our two groups, with the Anxiety group showing a decrease in the ratio of B cells to T cells from pregnancy to postpartum, whereas the Non-Anxiety women showed an increase in this ratio over time. Women in the Anxiety group also demonstrated an increased ratio of cytotoxic to helper T cells throughout pregnancy, a modest increase in the Th1:Th2 ratio across pregnancy, and a lower ratio of Th17:TREG cells in the postpartum as compared with Non-Anxiety women. These data suggest that the immune response throughout the antenatal period differs for women with anxiety symptoms compared to those without, suggestive of a unique immune phenotype of perinatal anxiety." @default.
• W4295736541 created "2022-09-15" @default.
• W4295736541 creator A5001494188 @default.
• W4295736541 creator A5017821275 @default.
• W4295736541 creator A5030486188 @default.
• W4295736541 creator A5034561869 @default.
• W4295736541 creator A5034733814 @default.
• W4295736541 creator A5048916292 @default.
• W4295736541 creator A5049972900 @default.
• W4295736541 date "2022-11-01" @default.
• W4295736541 modified "2023-10-16" @default.
• W4295736541 title "The immune phenotype of perinatal anxiety" @default.
• W4295736541 cites W104415939 @default.
• W4295736541 cites W1865005612 @default.
• W4295736541 cites W1951842251 @default.
• W4295736541 cites W1964168702 @default.
• W4295736541 cites W1967804150 @default.
• W4295736541 cites W1979423658 @default.
• W4295736541 cites W1986936121 @default.
• W4295736541 cites W1996299251 @default.
• W4295736541 cites W2000806250 @default.
• W4295736541 cites W2001558060 @default.
• W4295736541 cites W2001866454 @default.
• W4295736541 cites W2005068507 @default.
• W4295736541 cites W2021793765 @default.
• W4295736541 cites W2029051866 @default.
• W4295736541 cites W2033655746 @default.
• W4295736541 cites W2036899067 @default.
• W4295736541 cites W2037891682 @default.
• W4295736541 cites W2041445212 @default.
• W4295736541 cites W2044333985 @default.
• W4295736541 cites W2044620539 @default.
• W4295736541 cites W2046420685 @default.
• W4295736541 cites W2059329303 @default.
• W4295736541 cites W2059704497 @default.
• W4295736541 cites W2060468894 @default.
• W4295736541 cites W2060556672 @default.
• W4295736541 cites W2065015660 @default.
• W4295736541 cites W2066560204 @default.
• W4295736541 cites W2069250071 @default.
• W4295736541 cites W2070447896 @default.
• W4295736541 cites W2074520223 @default.
• W4295736541 cites W2080326569 @default.
• W4295736541 cites W2081823959 @default.
• W4295736541 cites W2090546229 @default.
• W4295736541 cites W2093274439 @default.
• W4295736541 cites W2097715719 @default.
• W4295736541 cites W2099516158 @default.
• W4295736541 cites W2149264570 @default.
• W4295736541 cites W2150691073 @default.
• W4295736541 cites W2151454086 @default.
• W4295736541 cites W2151487996 @default.
• W4295736541 cites W2302692460 @default.
• W4295736541 cites W2319768174 @default.
• W4295736541 cites W2417555976 @default.
• W4295736541 cites W2490331232 @default.
• W4295736541 cites W2517170026 @default.
• W4295736541 cites W2592199299 @default.
• W4295736541 cites W2593582630 @default.
• W4295736541 cites W2596338372 @default.
• W4295736541 cites W2766129136 @default.
• W4295736541 cites W2889100570 @default.
• W4295736541 cites W2889131270 @default.
• W4295736541 cites W2891097442 @default.
• W4295736541 cites W2901806432 @default.
• W4295736541 cites W2917718993 @default.
• W4295736541 cites W2918922922 @default.
• W4295736541 cites W2943751833 @default.
• W4295736541 cites W2944434778 @default.
• W4295736541 cites W2953025937 @default.
• W4295736541 cites W2955924044 @default.
• W4295736541 cites W2964215777 @default.
• W4295736541 cites W2969622624 @default.
• W4295736541 cites W2998747347 @default.
• W4295736541 cites W3008204058 @default.
• W4295736541 cites W3012016062 @default.
• W4295736541 cites W3049499252 @default.
• W4295736541 cites W3081224868 @default.
• W4295736541 cites W3105431649 @default.
• W4295736541 cites W3127565366 @default.
• W4295736541 cites W3136955135 @default.
• W4295736541 cites W3160672432 @default.
• W4295736541 cites W3183170346 @default.
• W4295736541 cites W3212335851 @default.
• W4295736541 cites W4200529942 @default.
• W4295736541 cites W4213295223 @default.
• W4295736541 cites W4213436284 @default.
• W4295736541 cites W4225085521 @default.
• W4295736541 cites W4225316167 @default.
• W4295736541 cites W3105651405 @default.
• W4295736541 doi "https://doi.org/10.1016/j.bbi.2022.09.005" @default.
• W4295736541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36115543" @default.
• W4295736541 hasPublicationYear "2022" @default.
• W4295736541 type Work @default.
• W4295736541 citedByCount "3" @default.
• W4295736541 countsByYear W42957365412023 @default.
• W4295736541 crossrefType "journal-article" @default.
• W4295736541 hasAuthorship W4295736541A5001494188 @default.

• next