FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295752904> ?p ?o ?g. }

• W4295752904 abstract "Abstract Background Early hepatocellular carcinoma (HCC) detection with non-invasive biomarkers remains an unmet clinical need. We aimed to construct a predictive model based on the pre-diagnostic levels of serum markers to predict the early-stage onset of HCC. Methods A total of 339 HCC patients (including 157 patients from Changzhou cohort and 182 patients from Wuxi cohort) were enrolled in our retrospective study. Levels of 25 baseline serum markers were collected. Propensity score matching (PSM) analysis was conducted to balance the distributions of patients’ gender, age, and the surveillance time between HCC group and control group. Then, Receiver operating characteristic (ROC) and Logistic regression analysis were performed to screen the independent predictive variables and construct a non-invasive predictive model. Subsequently, ROC curve and Kaplan–Meier (K–M) curve were used to evaluate the predictive values of the model. Clinical net benefit of the model was demonstrated by decision curve analysis (DCA) and clinical impact curve. Results Five independent predictive variables for HCC onset and two general characteristics of patients (age and gender) were incorporated into the score model. ROC and DCA curves showed that the score model had better predictive performance in discrimination and clinical net benefit compared with single variable or other score systems, with the area under the curve (AUC) of 0.890 (95% CI 0.856–0.925) in Changzhou cohort and 0.799 (95% CI 0.751–0.849) in Wuxi cohort. Meanwhile, stratification analysis indicated that the score model had good predictive values for patients with early tumor stage (AJCC stage I) or small tumors (< 2 cm). Moreover, the score of HCC patient began to increase at 30 months before clinical diagnosis and reach a peak at 6 months. Conclusion Based on this model, we could optimize the current risk stratification at an early stage and consider further intensive surveillance programs for high-risk patients. It could also help clinicians to evaluate the progression and predict the prognosis of HCC patients." @default.
• W4295752904 created "2022-09-15" @default.
• W4295752904 creator A5009787438 @default.
• W4295752904 creator A5019580460 @default.
• W4295752904 creator A5030092686 @default.
• W4295752904 creator A5048461976 @default.
• W4295752904 creator A5049396596 @default.
• W4295752904 creator A5051431915 @default.
• W4295752904 creator A5075002556 @default.
• W4295752904 creator A5085071467 @default.
• W4295752904 date "2022-09-13" @default.
• W4295752904 modified "2023-10-09" @default.
• W4295752904 title "Construction and validation of a predictive model for hepatocellular carcinoma based on serum markers" @default.
• W4295752904 cites W2033178592 @default.
• W4295752904 cites W2034116029 @default.
• W4295752904 cites W2034320803 @default.
• W4295752904 cites W2064387090 @default.
• W4295752904 cites W2084621740 @default.
• W4295752904 cites W2101782801 @default.
• W4295752904 cites W2119190881 @default.
• W4295752904 cites W2136150034 @default.
• W4295752904 cites W2168927463 @default.
• W4295752904 cites W2297875727 @default.
• W4295752904 cites W2314866596 @default.
• W4295752904 cites W2328176404 @default.
• W4295752904 cites W2409398911 @default.
• W4295752904 cites W2560658543 @default.
• W4295752904 cites W2750045027 @default.
• W4295752904 cites W2768651446 @default.
• W4295752904 cites W2787553551 @default.
• W4295752904 cites W2808244122 @default.
• W4295752904 cites W2889296039 @default.
• W4295752904 cites W2889646458 @default.
• W4295752904 cites W2890926168 @default.
• W4295752904 cites W2895926103 @default.
• W4295752904 cites W2900431092 @default.
• W4295752904 cites W2927467816 @default.
• W4295752904 cites W2937538955 @default.
• W4295752904 cites W2954227790 @default.
• W4295752904 cites W2979755615 @default.
• W4295752904 cites W3008307359 @default.
• W4295752904 cites W3107307884 @default.
• W4295752904 cites W3108323496 @default.
• W4295752904 cites W3167289731 @default.
• W4295752904 cites W3197451125 @default.
• W4295752904 cites W3200384611 @default.
• W4295752904 doi "https://doi.org/10.1186/s12876-022-02489-2" @default.
• W4295752904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36100887" @default.
• W4295752904 hasPublicationYear "2022" @default.
• W4295752904 type Work @default.
• W4295752904 citedByCount "0" @default.
• W4295752904 crossrefType "journal-article" @default.
• W4295752904 hasAuthorship W4295752904A5009787438 @default.
• W4295752904 hasAuthorship W4295752904A5019580460 @default.
• W4295752904 hasAuthorship W4295752904A5030092686 @default.
• W4295752904 hasAuthorship W4295752904A5048461976 @default.
• W4295752904 hasAuthorship W4295752904A5049396596 @default.
• W4295752904 hasAuthorship W4295752904A5051431915 @default.
• W4295752904 hasAuthorship W4295752904A5075002556 @default.
• W4295752904 hasAuthorship W4295752904A5085071467 @default.
• W4295752904 hasBestOaLocation W42957529041 @default.
• W4295752904 hasConcept C126322002 @default.
• W4295752904 hasConcept C143998085 @default.
• W4295752904 hasConcept C146357865 @default.
• W4295752904 hasConcept C151730666 @default.
• W4295752904 hasConcept C151956035 @default.
• W4295752904 hasConcept C167135981 @default.
• W4295752904 hasConcept C17923572 @default.
• W4295752904 hasConcept C198433322 @default.
• W4295752904 hasConcept C2778019345 @default.
• W4295752904 hasConcept C41260117 @default.
• W4295752904 hasConcept C58471807 @default.
• W4295752904 hasConcept C71924100 @default.
• W4295752904 hasConcept C72563966 @default.
• W4295752904 hasConcept C76318530 @default.
• W4295752904 hasConcept C86803240 @default.
• W4295752904 hasConceptScore W4295752904C126322002 @default.
• W4295752904 hasConceptScore W4295752904C143998085 @default.
• W4295752904 hasConceptScore W4295752904C146357865 @default.
• W4295752904 hasConceptScore W4295752904C151730666 @default.
• W4295752904 hasConceptScore W4295752904C151956035 @default.
• W4295752904 hasConceptScore W4295752904C167135981 @default.
• W4295752904 hasConceptScore W4295752904C17923572 @default.
• W4295752904 hasConceptScore W4295752904C198433322 @default.
• W4295752904 hasConceptScore W4295752904C2778019345 @default.
• W4295752904 hasConceptScore W4295752904C41260117 @default.
• W4295752904 hasConceptScore W4295752904C58471807 @default.
• W4295752904 hasConceptScore W4295752904C71924100 @default.
• W4295752904 hasConceptScore W4295752904C72563966 @default.
• W4295752904 hasConceptScore W4295752904C76318530 @default.
• W4295752904 hasConceptScore W4295752904C86803240 @default.
• W4295752904 hasIssue "1" @default.
• W4295752904 hasLocation W42957529041 @default.
• W4295752904 hasLocation W42957529042 @default.
• W4295752904 hasLocation W42957529043 @default.
• W4295752904 hasOpenAccess W4295752904 @default.
• W4295752904 hasPrimaryLocation W42957529041 @default.
• W4295752904 hasRelatedWork W2157758999 @default.
• W4295752904 hasRelatedWork W2300763755 @default.
• W4295752904 hasRelatedWork W2410105151 @default.

• next